Phosphatidylinositol 3-Kinases Concept

subject area of

• Actin filaments participate in the relocalization of phosphatidylinositol3-kinase to glucose transporter-containing compartments and in the stimulation of glucose uptake in 3T3-L1 adipocytes  Journal Articles
• Adenosine downregulates DPPIV on HT-29 colon cancer cells by stimulating protein tyrosine phosphatase(s) and reducing ERK1/2 activity via a novel pathway  Journal Articles
• Akt Is Activated in Response to an Apoptotic Signal  Journal Articles
• Anti-pneumococcal deficits of monocyte-derived macrophages from the advanced-age, frail elderly and related impairments in PI3K-AKT signaling  Journal Articles
• Apolipoprotein A1 Protects Against Necrotic Core Development in Atherosclerotic Plaques: PDZK1-Dependent High-Density Lipoprotein Suppression of Necroptosis in Macrophages  Journal Articles
• Association of Phosphorylated Epidermal Growth Factor Receptor with Survival in Patients with Locally Advanced Non-small Cell Lung Cancer Treated with Radiotherapy  Journal Articles
• Caveolin-1 regulation of Sp1 controls production of the antifibrotic protein follistatin in kidney mesangial cells  Journal Articles
• Cell surface expression of 78-kDa glucose-regulated protein (GRP78) mediates diabetic nephropathy  Journal Articles
• Characterization of sphere-propagating cells with stem-like properties from DU145 prostate cancer cells  Journal Articles
• Ciliary Neurotrophic Factor Stimulates Muscle Glucose Uptake by a PI3-Kinase–Dependent Pathway That Is Impaired With Obesity  Journal Articles
• Class A Scavenger Receptor–Mediated Double-Stranded RNA Internalization Is Independent of Innate Antiviral Signaling and Does Not Require Phosphatidylinositol 3-Kinase Activity  Journal Articles
• Co-existence of high levels of the PTEN protein with enhanced Akt activation in renal cell carcinoma  Journal Articles
• Collagen I induction by high glucose levels is mediated by epidermal growth factor receptor and phosphoinositide 3-kinase/Akt signalling in mesangial cells  Journal Articles
• Comprehensive analysis of mammalian miRNA* species and their role in myeloid cells  Journal Articles
• DLDTI: a learning-based framework for drug-target interaction identification using neural networks and network representation  Journal Articles
• Deconstructing human embryonic stem cell cultures: niche regulation of self-renewal and pluripotency  Journal Articles
• Development and validation of asthma risk prediction models using co-expression gene modules and machine learning methods  Journal Articles
• EGFR-PLCγ1 signaling mediates high glucose-induced PKCβ1-Akt activation and collagen I upregulation in mesangial cells  Journal Articles
• ERK kinases modulate the activation of PI3 kinase related kinases (PIKKs) in DNA damage response.  Journal Articles
• Effects of guanidinoacetic acid and coated folic acid supplementation on growth performance, nutrient digestion and hepatic gene expression in Angus bulls  Journal Articles
• Endoplasmic Reticulum Chaperone GRP78 Protects Heart From Ischemia/Reperfusion Injury Through Akt Activation  Journal Articles
• Exploring PI3Kδ Molecular Pathways in Stable COPD and Following an Acute Exacerbation, Two Randomized Controlled Trials  Journal Articles
• Extracellular Vesicles from BMSCs Prevent Glucocorticoid-Induced BMECs Injury by Regulating Autophagy via the PI3K/Akt/mTOR Pathway.  Journal Articles
• Extracellular matrix regulates human airway smooth muscle cell migration  Journal Articles
• Guanosine Inhibits CD40 Receptor Expression and Function Induced by Cytokines and β Amyloid in Mouse Microglia Cells  Journal Articles
• Guanosine Protects Glial Cells Against 6-Hydroxydopamine Toxicity  Journal Articles
• Heparin Synergistically Enhances Interleukin-11 Signaling through Up-regulation of the MAPK Pathway  Journal Articles
• Hepatic Apoptosis Postburn Is Mediated by C-Jun N-Terminal Kinase 2  Journal Articles
• High Glucose Up-regulates ADAM17 through HIF-1α in Mesangial Cells  Journal Articles
• High-density lipoprotein protects cardiomyocytes against necrosis induced by oxygen and glucose deprivation through SR-B1, PI3K, and AKT1 and 2  Journal Articles
• Hydrogen sulfide is a regulator of mammary gland development in prepubescent female mice  Journal Articles
• IGF-1 Protects Intestinal Epithelial Cells From Oxidative Stress-Induced Apoptosis  Journal Articles
• Identification of MEK- and phosphoinositide 3-kinase-dependent signalling as essential events during Chlamydia pneumoniae invasion of HEp2 cells  Journal Articles
• Identification of a Novel Pathway Essential for the Immediate-Early, Interferon-Independent Antiviral Response to Enveloped Virions  Journal Articles
• Insulin Activates a p21-activated Kinase in Muscle Cells via Phosphatidylinositol 3-Kinase  Journal Articles
• Insulin Attenuates Apoptosis and Exerts Anti-Inflammatory Effects in Endotoxemic Human Macrophages  Journal Articles
• Insulin increases FA uptake and esterification but reduces lipid utilization in isolated contracting muscle  Journal Articles
• Insulin, Insulin-like Growth Factor-I, and Platelet-Derived Growth Factor Activate Extracellular Signal-Regulated Kinase by Distinct Pathways in Muscle Cells  Journal Articles
• Insulin-like growth factors inhibit podocyte apoptosis through the PI3 kinase pathway  Journal Articles
• Interleukins 4 and 13 Increase Intestinal Epithelial Permeability by a Phosphatidylinositol 3-Kinase Pathway  Journal Articles
• Involvement of the actin network in insulin signalling.  Conferences
• Janus and PI3-kinases mediate glucocorticoid resistance in activated chronic leukemia cells  Journal Articles
• Macrophages Regulate Unilateral Ureteral Obstruction-Induced Renal Lymphangiogenesis through C-C Motif Chemokine Receptor 2–Dependent Phosphatidylinositol 3-Kinase-AKT–Mechanistic Target of Rapamycin Signaling and Hypoxia-Inducible Factor-1α/Vascular Endothelial Growth Factor-C Expression  Journal Articles
• Maternal nutrient restriction impairs young adult offspring ovarian signaling resulting in reproductive dysfunction and follicle loss†  Journal Articles
• Mechanical stretch-induced RhoA activation is mediated by the RhoGEF Vav2 in mesangial cells  Journal Articles
• Modelling the MYC-driven normal-to-tumour switch in breast cancer.  Journal Articles
• Mosaic Activating Mutations in FGFR1 Cause Encephalocraniocutaneous Lipomatosis  Journal Articles
• Multiple roles of phosphatidylinositol 3-kinase in regulation of glucose transport, amino acid transport, and glucose transporters in L6 skeletal muscle cells  Journal Articles
• Muscarinic excitation-contraction coupling mechanisms in tracheal and bronchial smooth muscles  Journal Articles
• Natural products for the treatment of neurodegenerative diseases  Journal Articles
• Oncostatin M induction of eotaxin-1 expression requires the convergence of PI3′K and ERK1/2 MAPK signal transduction pathways  Journal Articles
• Oncostatin M-Induced IL-6 Expression in Murine Fibroblasts Requires the Activation of Protein Kinase Cδ  Journal Articles
• Oncostatin-M Up-Regulates VCAM-1 and Synergizes with IL-4 in Eotaxin Expression: Involvement of STAT6  Journal Articles
• PKC-β1 Mediates Glucose-Induced Akt Activation and TGF-β1 Upregulation in Mesangial Cells  Journal Articles
• PTEN inhibits BMI1 function independently of its phosphatase activity  Journal Articles
• PTEN status is a crucial determinant of the functional outcome of combined MEK and mTOR inhibition in cancer  Journal Articles
• Peripheral Blood Gene Expression Changes during Allergen Inhalation Challenge in Atopic Asthmatic Individuals  Journal Articles
• Phase II study of temsirolimus (CCI-779) in women with recurrent, unresectable, locally advanced or metastatic carcinoma of the cervix. A trial of the NCIC Clinical Trials Group (NCIC CTG IND 199)  Journal Articles
• Phosphatidylinositol 3-kinase and the actin network are not required for the stimulation of glucose transport caused by mitochondrial uncoupling: comparison with insulin action  Journal Articles
• Phosphodiesterase 4D Regulates Baseline Sarcoplasmic Reticulum Ca ²⁺ Release and Cardiac Contractility, Independently of L-Type Ca ²⁺ Current  Journal Articles
• Phosphoinositide‐3 kinase activity in severe eosinophilic asthma with recurrent airway infections and neutrophilic exacerbations  Journal Articles
• Reactivation of epigenetically silenced miR-512 and miR-373 sensitizes lung cancer cells to cisplatin and restricts tumor growth  Journal Articles
• Regulation of profibrotic responses by ADAM17 activation in high glucose requires its C-terminus and FAK  Journal Articles
• Requirement and Redundancy of the Src Family Kinases Fyn and Lyn in Perforin-Dependent Killing of Cryptococcus neoformans by NK Cells  Journal Articles
• Requirement for Both Shc and Phosphatidylinositol 3′ Kinase Signaling Pathways in Polyomavirus Middle T-Mediated Mammary Tumorigenesis  Journal Articles
• Role of the actin cytoskeleton in insulin action  Journal Articles
• SREBP-1 Mediates Angiotensin II-Induced TGF-β1 Upregulation and Glomerular Fibrosis  Journal Articles
• SREBP-1 activation by glucose mediates TGF-β upregulation in mesangial cells  Journal Articles
• Selective involvement of the PI3K/PKB/bad pathway in retinal cell death  Journal Articles
• Shear flow-induced motility ofDictyostelium discoideumcells on solid substrate  Journal Articles
• Stretch-induced Raf-1 activation in mesangial cells requires actin cytoskeletal integrity  Journal Articles
• Superantigen immune stimulation activates epithelial STAT-1 and PI 3-K: PI 3-K regulation of permeability  Journal Articles
• Synergistic effects of pi3k/akt on abrogation of cytokine-dependency induced by oncogenic raf  Journal Articles
• Targeting PI3K-p110α Suppresses Influenza Virus Infection in Chronic Obstructive Pulmonary Disease  Journal Articles
• Telomerase Mediates Vascular Endothelial Growth Factor-dependent Responsiveness in a Rat Model of Hind Limb Ischemia  Journal Articles
• The antiapoptotic effect of guanosine is mediated by the activation of the PI 3‐kinase/AKT/PKB pathway in cultured rat astrocytes  Journal Articles
• The mitogen-activated protein kinase (MAPK) cascade controls phosphatase and tensin homolog (PTEN) expression through multiple mechanisms  Journal Articles
• Uncoupling of Pro- and Anti-Inflammatory Properties of Staphylococcus aureus  Journal Articles