Journal article
Insulin Attenuates Apoptosis and Exerts Anti-Inflammatory Effects in Endotoxemic Human Macrophages
Abstract
BACKGROUND: Insulin decreases the incidence of sepsis and improves mortality of critically ill patients. In endotoxemic as well as in thermally injured rats, insulin attenuates the systemic inflammatory response by decreasing the proinflammatory and increasing the antiinflammatory cascade. The aim of the present study was to determine the effects of insulin on cell survival, cell activity, apoptosis, and proinflammatory response in a human …
Authors
Leffler M; Hrach T; Stuerzl M; Horch RE; Herndon DN; Jeschke MG
Journal
Journal of Surgical Research, Vol. 143, No. 2, pp. 398–406
Publisher
Elsevier
Publication Date
December 2007
DOI
10.1016/j.jss.2007.01.030
ISSN
0022-4804