Journal article
Insulin-like growth factors inhibit podocyte apoptosis through the PI3 kinase pathway
Abstract
BACKGROUND: Abnormal podocyte development and progressive podocyte injury have been implicated in a number of human kidney diseases. Factors necessary for regulating development and maintenance of this cell type are only beginning to emerge.
METHODS: To study the role of the insulin-like growth factor (IGF) system in regulating podocyte survival, we induced human fetal podocytes to undergo apoptosis. We demonstrated a significant increase in …
Authors
Bridgewater DJ; Ho J; Sauro V; Matsell DG
Journal
Kidney International, Vol. 67, No. 4, pp. 1308–1314
Publisher
Elsevier
Publication Date
April 2005
DOI
10.1111/j.1523-1755.2005.00208.x
ISSN
0085-2538