Journal article
SREBP-1 activation by glucose mediates TGF-β upregulation in mesangial cells
Abstract
Glomerular matrix accumulation is a hallmark of diabetic nephropathy. Recent studies showed that overexpression of the transcription factor sterol-responsive element-binding protein (SREBP)-1 induces pathology reminiscent of diabetic nephropathy, and SREBP-1 upregulation was observed in diabetic kidneys. We thus studied whether SREBP-1 is activated by high glucose (HG) and mediates its profibrogenic responses. In primary rat mesangial cells, HG …
Authors
Uttarwar L; Gao B; Ingram AJ; Krepinsky JC
Journal
American Journal of Physiology. Renal physiology, Vol. 302, No. 3, pp. f329–f341
Publisher
American Physiological Society
Publication Date
February 1, 2012
DOI
10.1152/ajprenal.00136.2011
ISSN
0363-6127
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AnimalsDiabetes Mellitus, ExperimentalDiabetic NephropathiesErbB ReceptorsGlucoseIntracellular Signaling Peptides and ProteinsMembrane ProteinsMesangial CellsMiceMice, Inbred StrainsPhosphatidylinositol 3-KinasesPrimary Cell CulturePromoter Regions, GeneticProto-Oncogene Proteins c-aktRatsRats, Sprague-DawleySignal TransductionSterol Regulatory Element Binding Protein 1Transcriptional ActivationTransforming Growth Factor beta1Up-RegulationrhoA GTP-Binding Protein