Journal article
Anti-pneumococcal deficits of monocyte-derived macrophages from the advanced-age, frail elderly and related impairments in PI3K-AKT signaling
Abstract
The advanced-age, frail elderly are especially vulnerable to developing pneumococcal infection and disease. Macrophages are critical mediators in the defence against Streptococcus pneumoniae at the upper respiratory tract, however, little is known of their anti-pneumococcal capacity in the elderly. Herein we demonstrate that monocyte-derived macrophages (MDMs) from the advanced-age, frail elderly produce less TNF, IL-6, IL-1β and IL-8 in …
Authors
Verschoor CP; Johnstone J; Loeb M; Bramson JL; Bowdish DME
Journal
Human Immunology, Vol. 75, No. 12, pp. 1192–1196
Publisher
Elsevier
Publication Date
December 2014
DOI
10.1016/j.humimm.2014.10.004
ISSN
0198-8859
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AdultAge FactorsAgedAged, 80 and overAndrostadienesChromonesDisease SusceptibilityFrail ElderlyHumansInterleukin-1betaInterleukin-6Interleukin-8MacrophagesMiddle AgedMorpholinesPhagocytosisPhosphatidylinositol 3-KinasesPhosphoinositide-3 Kinase InhibitorsPneumonia, PneumococcalProto-Oncogene Proteins c-aktSignal TransductionStreptococcus pneumoniaeTumor Necrosis Factor-alphaWortmanninYoung Adult