Journal article
Exploring PI3Kδ Molecular Pathways in Stable COPD and Following an Acute Exacerbation, Two Randomized Controlled Trials
Abstract
Background: Inhibition of phosphoinositide 3-kinase δ (PI3Kδ) exerts corrective effects on the dysregulated migration characteristics of neutrophils isolated from patients with chronic obstructive pulmonary disease (COPD).
Objective: To develop novel, induced sputum endpoints to demonstrate changes in neutrophil phenotype in the lung by administering nemiralisib, a potent and selective inhaled PI3Kδ inhibitor, to patients with stable COPD or …
Authors
Begg M; Hamblin JN; Jarvis E; Bradley G; Mark S; Michalovich D; Lennon M; Wajdner HE; Amour A; Wilson R
Journal
International Journal of Chronic Obstructive Pulmonary Disease, Vol. 16, No. 0, pp. 1621–1636
Publisher
Taylor & Francis
Publication Date
June 3, 2021
DOI
10.2147/copd.s309303
ISSN
1176-9106