Journal article
Janus and PI3-kinases mediate glucocorticoid resistance in activated chronic leukemia cells
Abstract
Glucorticoids (GCs) such as dexamethasone (DEX) remain important treatments for Chronic Lymphocytic Leukemia (CLL) but the mechanisms are poorly understood and resistance is inevitable. Proliferation centers (PC) in lymph nodes and bone marrow offer protection against many cytotoxic drugs and circulating CLL cells were found to acquire resistance to DEX-mediated killing in conditions encountered in PCs including stimulation by toll-like …
Authors
Oppermann S; Lam AJ; Tung S; Shi Y; McCaw L; Wang G; Ylanko J; Leber B; Andrews D; Spaner DE
Journal
Oncotarget, Vol. 5, No. 0, pp. 72608–72621
Publisher
Impact Journals
Publication Date
November 8, 2016
DOI
10.18632/oncotarget.11618
ISSN
1949-2553