Mutagenesis, Site-Directed
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A New Function of Human HtrA2 as an Amyloid-β Oligomerization Inhibitor Academic Article
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A Thiolate Anion Buried within the Hydrocarbon Ruler Perturbs PagP Lipid Acyl Chain Selection Academic Article
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A conserved MADS-box phosphorylation motif regulates differentiation and mitochondrial function in skeletal, cardiac, and smooth muscle cells Academic Article
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A covalently linked recombinant albumin dimer is more rapidly cleared in vivo than are wild-type and mutant C34A albumin Academic Article
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A critical role for the C-terminus of Nej1 protein in Lif1p association, DNA binding and non-homologous end-joining Academic Article
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A glycosyl hydrolase activity of mammalian reovirus σ1 protein can contribute to viral infection through a mucus layer 1 1Edited by M. Yaniv Academic Article
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A p56 Ligand Serves as a Coactivator of an Orphan Nuclear Hormone Receptor Academic Article
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Active site labeling of the gentamicin resistance enzyme AAC(6')-APH(2") by the lipid kinase inhibitor wortmannin Academic Article
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Aerial development in Streptomyces coelicolor requires sortase activity Academic Article
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Altering Heparin Cofactor II at VAL439 (P6) either Impairs Inhibition of Thrombin or Confers Elastase Resistance Academic Article
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Amino Acid Substitutions in the Herpes Simplex Virus Transactivator VP16 Uncouple Direct Protein-Protein Interaction and DNA Binding from Complex Assembly and Transactivation Academic Article
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Amino acid substitutions of the P2 residue of human antithrombin that either enhance or impair function Academic Article
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Amplification of TGFβ Induced ITGB6 Gene Transcription May Promote Pulmonary Fibrosis Academic Article
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Application of Combinatorial Libraries and Protein Engineering to the Discovery of Novel Anti-Thrombotic Drugs Conference Paper
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BCL11A represses HBG transcription in K562 cells Academic Article
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BRAF status modulates Interelukin-8 expression through a CHOP-dependent mechanism in colorectal cancer Academic Article
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Bax Homodimerization Is Not Required for Bax to Accelerate Chemotherapy-induced Cell Death Academic Article
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Bcl-2 changes conformation to inhibit Bax oligomerization Academic Article
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Binding Site Determinants for the LysR-Type Transcriptional Regulator PcaQ in the Legume Endosymbiont
Sinorhizobium meliloti Academic Article
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Catalytic Mechanism of Fungal Homoserine Transacetylase Academic Article
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Characterization of a cryptic plasmid from Pseudomonas sp. and utilization of its temperature-sensitive derivatives for genetic manipulation Academic Article
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Characterization of mice harboring a variant of EPCR with impaired ability to bind protein C: novel role of EPCR in hematopoiesis Academic Article
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Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity Academic Article
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Cleavage-dependent Ligation by the FLP Recombinase Academic Article
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Common β-lactamases inhibit bacterial biofilm formation Academic Article
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Computational Study of the Binding Modes of Caffeine to the Adenosine A2A Receptor Academic Article
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Conserved, unstructured regions in Pseudomonas aeruginosa PilO are important for type IVa pilus function Academic Article
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Control of Centromere Localization of the MEI-S332 Cohesion Protection Protein Academic Article
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Control of Motoneuron Survival by Angiogenin Academic Article
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Crystal Structure of Anticoagulant Thrombin Variant E217K Provides Insights into Thrombin Allostery Academic Article
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Crystal Structure of the Passenger Domain of the Escherichia coli Autotransporter EspP Academic Article
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Cyclin B-dependent kinase 1 regulates human TRF1 to modulate the resolution of sister telomeres Academic Article
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Cyclin-dependent Kinase 5 (Cdk5) Activation Domain of Neuronal Cdk5 Activator Academic Article
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Cytokine-Induced Hepatic Apoptosis Is Dependent on FGL2/Fibroleukin: The Role of Sp1/Sp3 and STAT1/PU.1 Composite cis Elements Academic Article
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Definition of a Consensus Transportin-specific Nucleocytoplasmic Transport Signal Academic Article
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Determination of the origin-specific DNA-binding domain of polyomavirus large T antigen Academic Article
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Different binding sites for the neuropeptide Y Y1 antagonists 1229U91 and J-104870 on human Y1 receptors Academic Article
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Dissociation of Thrombin's Substrate Interactions Using Site-Directed Mutagenesis Academic Article
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Distinct lipid effects on tBid and Bim activation of membrane permeabilization by pro-apoptotic Bax Academic Article
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Distinct surfaces on Cdc5/PLK Polo-box domain orchestrate combinatorial substrate recognition during cell division Academic Article
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Dynamic and tissue-specific proteolytic processing of chemerin in obese mice Academic Article
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Effects of Double-Site Mutations of Vesicular Stomatitis Virus Glycoprotein G on Membrane Fusion Activity Academic Article
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Effects of deletions in the carboxy-terminal hydrophobic region of herpes simplex virus glycoprotein gB on intracellular transport and membrane anchoring Academic Article
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Effects of metal binding affinity on the chemical and thermal stability of site-directed mutants of rat oncomodulin Academic Article
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Eliminating Competition: Characterizing and Eliminating Competitive Binding at Separate Sites between DAHP Synthase’s Essential Metal Ion and the Inhibitor DAHP Oxime Academic Article
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Evidence That the Epidermal Growth Factor Receptor on Host Cells Confers Reovirus Infection Efficiency Academic Article
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Evidence that Herpes Simplex Virus VP16 Is Required for Viral Egress Downstream of the Initial Envelopment Event Academic Article
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Expression and purification of recombinant human receptor for advanced glycation endproducts in Escherichia coli Academic Article
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Expression in a cell-free system of normal and variant forms of human antithrombin III. Ability to bind heparin and react with alpha-thrombin Academic Article
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Factor VII Deficiency Caused by a Structural Variant N57D of the First Epidermal Growth Factor Domain Academic Article
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Factors Determining Vesicular Lipid Mixing Induced by Shortened Constructs of Influenza Hemagglutinin Academic Article
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Function and Redundancy of the Chaplin Cell Surface Proteins in Aerial Hypha Formation, Rodlet Assembly, and Viability in
Streptomyces coelicolor Academic Article
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Functional Analysis of Disulfide Linkages Clustered within the Amino Terminus of Human Apolipoprotein B Academic Article
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Functional Mapping of the Surface Residues of Human Thrombin Academic Article
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Functional role of conserved residues in the characteristic secretion NTPase motifs of the Pseudomonas aeruginosa type IV pilus motor proteins PilB, PilT and PilU Academic Article
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Functionally important amino acids in Saccharomyces cerevisiae aspartate kinase Academic Article
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Gene transcription of fgl2 in endothelial cells is controlled by Ets-1 and Oct-1 and requires the presence of both Sp1 and Sp3 Academic Article
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Heparin cofactor II is more sensitive than antithrombin to secretory impairment arising from mutations introduced into its carboxy-terminal region Academic Article
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Homology Model of Dihydropyridine Receptor: Implications for L-type Ca2+ Channel Modulation by Agonists and Antagonists Academic Article
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How Batrachotoxin Modifies the Sodium Channel Permeation Pathway: Computer Modeling and Site-Directed Mutagenesis Academic Article
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HypF, a Carbamoyl Phosphate-converting Enzyme Involved in [NiFe] Hydrogenase Maturation Academic Article
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IMPACT OF MUTATIONS AT THE P4 AND P5 POSITIONS ON THE REACTION OF ANTITHROMBIN WITH THROMBIN AND ELASTASE Academic Article
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Identification and analysis of all components of a gel retardation assay by combination with immunoblotting. Academic Article
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Identification of Critical Residues on Thrombin Mediating Its Interaction with Fibrin Academic Article
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Identification of a cluster of residues in transmembrane segment 6 of domain III of the cockroach sodium channel essential for the action of pyrethroid insecticides Academic Article
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Identification of the Catalytic Residues of AroA (Enolpyruvylshikimate 3-Phosphate Synthase) Using Partitioning Analysis Academic Article
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Identification of the Factor VIIa Binding Site on Tissue Factor by Homologous Loop Swap and Alanine Scanning Mutagenesis Academic Article
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Immunohistochemical staining for tilapia and human insulin demonstrates that a tilapia transgenic for humanized insulin is a mosaic Academic Article
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Inscribing the Perimeter of the PagP Hydrocarbon Ruler by Site-Specific Chemical Alkylation Academic Article
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Intracellular events determine the fate of antithrombin Utah Academic Article
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Involvement of a calpain-like protease in the processing of the murine interleukin 1 alpha precursor Academic Article
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Kinetic Analysis of a Unique Direct Prothrombinase, fgl2, and Identification of a Serine Residue Critical for the Prothrombinase Activity Academic Article
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Lipid binding activity of a neuron-specific protein NAP-22 studied in vivo and in vitro Academic Article
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Mechanism of allosteric inhibition in the Plasmodium falciparum cGMP-dependent protein kinase Conference Paper
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Mechanism of aminoglycoside 3'-phosphotransferase type IIIa: His188 is not a phosphate-accepting residue Academic Article
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Mechanism of aminoglycoside antibiotic kinase APH(3')-IIIa: role of the nucleotide positioning loop Academic Article
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Modification of
Pseudomonas aeruginosa
Pa5196 Type IV Pilins at Multiple Sites with
d
-Ara
f
by a Novel GT-C Family Arabinosyltransferase, TfpW Academic Article
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Modularity of protein function: Chimeric interleukin 1.beta.s containing specific protease inhibitor loops retain function of both molecules Academic Article
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Modulation of Clearance of Recombinant Serum Albumin by Either Glycosylation or Truncation Academic Article
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Molecular Mechanism for Lateral Lipid Diffusion between the Outer Membrane External Leaflet and a β-Barrel Hydrocarbon Ruler Academic Article
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Molecular Mechanism of the Enterococcal Aminoglycoside 6‘-N-Acetyltransferase‘: Role of GNAT-Conserved Residues in the Chemistry of Antibiotic Inactivation Academic Article
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Molecular evidence for dual pyrethroid-receptor sites on a mosquito sodium channel Academic Article
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Molecular mechanism of VanHst, an alpha-ketoacid dehydrogenase required for glycopeptide antibiotic resistance from a glycopeptide producing organism Academic Article
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Molecular mechanism of aminoglycoside antibiotic kinase APH(3')-IIIa: roles of conserved active site residues Academic Article
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Mutagenesis and peptide analysis of the DRY motif in the α2A adrenergic receptor: evidence for alternate mechanisms in G protein-coupled receptors Academic Article
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Mutation of Any Site of N-Linked Glycosylation Accelerates the In Vivo Clearance of Recombinant Rabbit Antithrombin Academic Article
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Mutational analysis of state-dependent contacts in the pore module of eukaryotic sodium channels Academic Article
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Mutations in a Carboxy-Terminal Region of Vesicular Stomatitis Virus Glycoprotein G That Affect Membrane Fusion Activity Academic Article
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Mutations of AKT3 are associated with a wide spectrum of developmental disorders including extreme megalencephaly Academic Article
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NDPK-D (NM23-H4)-mediated externalization of cardiolipin enables elimination of depolarized mitochondria by mitophagy Academic Article
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NMR Structures Reveal How Oxidation Inactivates Thrombomodulin Academic Article
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NleG Type 3 Effectors from Enterohaemorrhagic Escherichia coli Are U-Box E3 Ubiquitin Ligases Academic Article
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Nuclear import of the BTB/POZ transcriptional regulator Kaiso Academic Article
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On the Interaction Between gp41 and Membranes: The Immunodominant Loop Stabilizes gp41 Helical Hairpin Conformation Academic Article
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Pentavalent Ions Dependency Is a Conserved Property of Adenosine Kinase from Diverse Sources: Identification of a Novel Motif Implicated in Phosphate and Magnesium Ion Binding and Substrate Inhibition Academic Article
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Pervasive Cryptic Epistasis in Molecular Evolution Academic Article
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PhoU Allows Rapid Adaptation to High Phosphate Concentrations by Modulating PstSCAB Transport Rate in Sinorhizobium meliloti Academic Article
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Phosphorylation at the carboxy terminus of the 55-kilodalton adenovirus type 5 E1B protein regulates transforming activity Academic Article
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PilF Is an Outer Membrane Lipoprotein Required for Multimerization and Localization of the
Pseudomonas aeruginosa
Type IV Pilus Secretin Academic Article
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Polyphosphate binds with high affinity to exosite II of thrombin Academic Article
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Potent Antithrombin Activity and Delayed Clearance From the Circulation Characterize Recombinant Hirudin Genetically Fused to Albumin Academic Article
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Predominant Interactions between μ-Conotoxin Arg-13 and the Skeletal Muscle Na+ Channel Localized by Mutant Cycle Analysis Academic Article
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Processing of the Papain Precursor Academic Article
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Protein Engineering Thrombin for Optimal Specificity and Potency of Anticoagulant Activity in Vivo Academic Article
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Proteolytic Cleavage of Ataxin-7 by Caspase-7 Modulates Cellular Toxicity and Transcriptional Dysregulation Academic Article
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Quorum sensing in
Escherichia coli
,
Salmonella typhimurium
, and
Vibrio harveyi
: A new family of genes responsible for autoinducer production Academic Article
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Rapid Insulin-like Growth Factor-1-induced Changes in Granulosa Cell Thrombospondin-1 Expression In Vitro Academic Article
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Reduction Precedes Cytidylyl Transfer without Substrate Channeling in Distinct Active Sites of the Bifunctional CDP-Ribitol Synthase from Haemophilus influenzae Academic Article
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Regulation of Smurf2 Ubiquitin Ligase Activity by Anchoring the E2 to the HECT Domain Academic Article
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Regulation of thrombospondin-1 expression through AU-rich elements in the 3′UTR of the mRNA Academic Article
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Repellent Signaling by Slit Requires the Leucine-Rich Repeats Academic Article
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Requirement of Lysine Residues Outside of the Proposed Pentasaccharide Binding Region for High Affinity Heparin Binding and Activation of Human Antithrombin III Academic Article
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RhoA Activation in Mesangial Cells by Mechanical Strain Depends on Caveolae and Caveolin-1 Interaction Academic Article
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Role of the Integrin-Binding Protein Osteopontin in Lymphatic Metastasis of Breast Cancer Academic Article
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Serine-401 as a batrachotoxin- and local anesthetic-sensing residue in the human cardiac Na+ channel Academic Article
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Signals for local and systemic responses of plants to pathogen attack Academic Article
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Site-directed mutagenesis and DNA sequence of pckA of Rhizobium NGR234, encoding phosphoenolpyruvate carboxykinase: gluconeogenesis and host-dependent symbiotic phenotype Academic Article
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Site-directed mutagenesis of alanine-382 of human antithrombin III Academic Article
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Site-directed mutagenesis of the P2 residue of human antithrombin Academic Article
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Solution structure and dynamics of the outer membrane enzyme PagP by NMR Academic Article
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Spectinomycin kinase from Legionella pneumophila. Characterization of substrate specificity and identification of catalytically important residues Academic Article
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Structural Basis for Cyclic-Nucleotide Selectivity and cGMP-Selective Activation of PKG I Academic Article
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Structural Insights into the Regulation of Foreign Genes in Salmonella by the Hha/H-NS Complex Academic Article
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Structural basis for streptogramin B resistance in
Staphylococcus aureus
by virginiamycin B lyase Academic Article
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Structural basis for the emission of violet bioluminescence from a W92F obelin mutant Academic Article
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Structural modifications of outer membrane vesicles to refine them as vaccine delivery vehicles Academic Article
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Structural requirements for the activation of human factor VIII by thrombin Academic Article
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Structure and Activity of the Metal-independent Fructose-1,6-bisphosphatase YK23 from Saccharomyces cerevisiae Academic Article
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Structure and Function of Sedoheptulose-7-phosphate Isomerase, a Critical Enzyme for Lipopolysaccharide Biosynthesis and a Target for Antibiotic Adjuvants Academic Article
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Structure-Activity Studies on Mammalian Adenosine Kinase Academic Article
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Structure-Function Analyses of Thrombomodulin by Gene-Targeting in Mice: The Cytoplasmic Domain Is Not Required for Normal Fetal Development Academic Article
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TATA-binding protein activates transcription when upstream of a GCN4-binding site in a novel yeast promoter. Academic Article
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Targeted mutagenesis of zebrafish antithrombin III triggers disseminated intravascular coagulation and thrombosis, revealing insight into function Academic Article
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The N-terminal domain of antithrombin-III is essential for heparin binding and complex-formation with, but not cleavage by, α-thrombin Academic Article
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The COOH terminus of aminoglycoside phosphotransferase (3')-IIIa is critical for antibiotic recognition and resistance Academic Article
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The Efficient Cellular Uptake of High Density Lipoprotein Lipids via Scavenger Receptor Class B Type I Requires Not Only Receptor-mediated Surface Binding but Also Receptor-specific Lipid Transfer Mediated by Its Extracellular Domain Academic Article
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The Functional Role of Conserved Acidic Residues of the Qcr7 Protein of the Cytochrome bc1 Complex in Saccharomyces cerevisiae Academic Article
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The Guanylyltransferase Domain of Mammalian mRNA Capping Enzyme Binds to the Phosphorylated Carboxyl-terminal Domain of RNA Polymerase II Academic Article
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The Membrane-Proximal Region of Vesicular Stomatitis Virus Glycoprotein G Ectodomain Is Critical for Fusion and Virus Infectivity Academic Article
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The PEA3 Subfamily of Ets Transcription Factors Synergizes with β-Catenin–LEF-1 To Activate Matrilysin Transcription in Intestinal Tumors Academic Article
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The Platform Protein Is Essential for Type IV Pilus Biogenesis Academic Article
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The Transactivation Function of the Pea3 Subfamily Ets Transcription Factors Is Regulated by Sumoylation Academic Article
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The Transcriptional Repressor ZEB Regulates p73 Expression at the Crossroad between Proliferation and Differentiation Academic Article
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The constitutive activation of the CEF-4/9E3 chemokine gene depends on C/EBPβ in v-src transformed chicken embryo fibroblasts Academic Article
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The molecular basis of the expansive substrate specificity of the antibiotic resistance enzyme aminoglycoside acetyltransferase-6'-aminoglycoside phosphotransferase-2". The role of ASP-99 as an active site base important for acetyl transfer Academic Article
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The nerve growth factor precursor proNGF exhibits neurotrophic activity but is less active than mature nerve growth factor Academic Article
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The structural basis of molecular adaptation Academic Article
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Thrombin Activation of Factor XI on Activated Platelets Requires the Interaction of Factor XI and Platelet Glycoprotein Ibα with Thrombin Anion-binding Exosites I and II, Respectively Academic Article
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Two Conserved Histidine Residues Are Critical to the Function of the TagF-like Family of Enzymes Academic Article
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XPF with mutations in its conserved nuclease domain is defective in DNA repair but functions in TRF2-mediated telomere shortening Academic Article
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ndvF, a novel locus located on megaplasmid pRmeSU47b (pEXO) of Rhizobium meliloti, is required for normal nodule development Academic Article