Journal article
Cyclin B-dependent kinase 1 regulates human TRF1 to modulate the resolution of sister telomeres
Abstract
Cyclin B-Cdk1 is a key mediator of mitotic entry; however, little is known about its role in the separation of sister chromatids. Here we report that upon mitotic entry, Cdk1 specifically phosphorylates threonine 371 of TRF1, a telomere binding protein implicated in the regulation of sister telomere cohesion. Such phosphorylation is removed in late mitosis when Cdk1 activity is inhibited, indicative of a tight regulation of T371 …
Authors
McKerlie M; Zhu X-D
Journal
Nature Communications, Vol. 2, No. 1,
Publisher
Springer Nature
DOI
10.1038/ncomms1372
ISSN
2041-1723