Journal article
Bcl‐2 changes conformation to inhibit Bax oligomerization
Abstract
Bcl‐2 inhibits apoptosis by regulating the release of cytochrome c and other proteins from mitochondria. Oligomerization of Bax promotes cell death by permeabilizing the outer mitochondrial membrane. In transfected cells and isolated mitochondria, Bcl‐2, but not the inactive point mutants Bcl‐2‐G145A and Bcl‐2‐V159D, undergoes a conformation change in the mitochondrial membrane in response to apoptotic agonists such as tBid and Bax. A mutant …
Authors
Dlugosz PJ; Billen LP; Annis MG; Zhu W; Zhang Z; Lin J; Leber B; Andrews DW
Journal
The EMBO Journal, Vol. 25, No. 11, pp. 2287–2296
Publisher
Springer Nature
Publication Date
June 7, 2006
DOI
10.1038/sj.emboj.7601126
ISSN
0261-4189