HEK293 Cells
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A biallelic pathogenic variant in the
OGDH
gene results in a neurological disorder with features of a mitochondrial disease Academic Article
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A dominant autoinflammatory disease caused by non-cleavable variants of RIPK1 Academic Article
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A naturally occurring transcript variant of MARCO reveals the SRCR domain is critical for function Academic Article
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A rapid in vitro methodology for simultaneous target discovery and antibody generation against functional cell subpopulations Academic Article
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AAV-mediated expression of 3TSR inhibits tumor and metastatic lesion development and extends survival in a murine model of epithelial ovarian carcinoma Academic Article
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ARMMs as a versatile platform for intracellular delivery of macromolecules Academic Article
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ATM and ATR Signaling Regulate the Recruitment of Human Telomerase to Telomeres Academic Article
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ATM kinase enables the functional axis of YAP, PML and p53 to ameliorate loss of Werner protein-mediated oncogenic senescence Academic Article
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Active-site mTOR inhibitors augment HSV1-dICP0 infection in cancer cells via dysregulated eIF4E/4E-BP axis Academic Article
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Alpha-1 proteinase inhibitor M358R reduces thrombin generation when displayed on the surface of cells expressing tissue factor Academic Article
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Alveolar macrophages are critical for broadly-reactive antibody-mediated protection against influenza A virus in mice Academic Article
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An Endogenous Reactive Oxygen Species (ROS)-Activated Histone Deacetylase Inhibitor Prodrug for Cancer Chemotherapy Academic Article
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Analysis of purified Wild type and mutant adenovirus particles by SILAC based quantitative proteomics Academic Article
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Antibodies Encoded by FCRL4-Bearing Memory B Cells Preferentially Recognize Commensal Microbial Antigens Academic Article
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Asialoglycoprotein receptor 1 is a novel PCSK9-independent ligand of liver LDLR cleaved by furin Academic Article
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Autism associated mutations in β2 subunit of voltage-gated calcium channels constitutively activate gene expression Academic Article
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Base-pair conformational switch modulates miR-34a targeting of Sirt1 mRNA Academic Article
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Bioinformatic discovery of a toxin family in Chryseobacterium piperi with sequence similarity to botulinum neurotoxins Academic Article
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Both Neutralizing and Non-Neutralizing Human H7N9 Influenza Vaccine-Induced Monoclonal Antibodies Confer Protection Academic Article
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CARMA3 Is a Host Factor Regulating the Balance of Inflammatory and Antiviral Responses against Viral Infection Academic Article
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CYB5D2 displays tumor suppression activities towards cervical cancer Academic Article
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Calcium as a reliable marker for the quantitative assessment of endoplasmic reticulum stress in live cells Academic Article
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Characterization of a novel SCN5A genetic variant A1294G associated with mixed clinical phenotype Academic Article
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Childhood amyotrophic lateral sclerosis caused by excess sphingolipid synthesis Academic Article
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Clear cell renal cell carcinoma induces fibroblast-mediated production of stromal periostin Academic Article
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Cockayne syndrome group B protein regulates fork restart, fork progression and MRE11-dependent fork degradation in BRCA1/2-deficient cells Academic Article
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Common DISC1 Polymorphisms Disrupt Wnt/GSK3β Signaling and Brain Development Academic Article
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Comparison of mammalian and bacterial expression library screening to detect recombinant alpha-1 proteinase inhibitor variants with enhanced thrombin inhibitory capacity☆ Academic Article
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Comparison of the Proinflammatory and Procoagulant Properties of Nuclear, Mitochondrial, and Bacterial DNA Academic Article
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Complete Disruption of Autism-Susceptibility Genes by Gene Editing Predominantly Reduces Functional Connectivity of Isogenic Human Neurons Academic Article
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Congenital myasthenic syndrome–associated agrin variants affect clustering of acetylcholine receptors in a domain-specific manner Academic Article
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Covalent Immune Recruiters: Tools to Gain Chemical Control Over Immune Recognition Academic Article
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Cystathionine Protects against Endoplasmic Reticulum Stress-induced Lipid Accumulation, Tissue Injury, and Apoptotic Cell Death Academic Article
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Discovery of Butyrylcholinesterase-Activated Near-Infrared Fluorogenic Probe for Live-Cell and In Vivo Imaging Academic Article
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Early evolutionary loss of the lipid A modifying enzyme PagP resulting in innate immune evasion in
Yersinia pestis Academic Article
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Elevated basal transcription can underlie timothy channel association with autism related disorders Academic Article
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Encephalitis with refractory seizures, status epilepticus, and antibodies to the GABAA receptor: a case series, characterisation of the antigen, and analysis of the effects of antibodies Academic Article
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Engineered human Tmpk fused with truncated cell-surface markers: versatile cell-fate control safety cassettes Academic Article
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Evaluation of Genes Encoding for the Transient Outward Current (Ito) Identifies the
KCND2
Gene as a Cause of J-Wave Syndrome Associated With Sudden Cardiac Death Academic Article
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Fine-Tuning of the RIG-I-Like Receptor/Interferon Regulatory Factor 3-Dependent Antiviral Innate Immune Response by the Glycogen Synthase Kinase 3/β-Catenin Pathway Academic Article
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Functional Effects of Epilepsy Associated KCNT1 Mutations Suggest Pathogenesis via Aberrant Inhibitory Neuronal Activity Academic Article
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Functional diversification of the NleG effector family in enterohemorrhagic
Escherichia coli Academic Article
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Gain-of-function mutations in IFIH1 cause a spectrum of human disease phenotypes associated with upregulated type I interferon signaling Academic Article
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HIV-1 gp120 Induces TLR2- and TLR4-Mediated Innate Immune Activation in Human Female Genital Epithelium Academic Article
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Human-Specific Mutations and Positively Selected Sites in MARCO Confer Functional Changes Academic Article
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Identification of a Botulinum Neurotoxin-like Toxin in a Commensal Strain of Enterococcus faecium Academic Article
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Imipridone Anticancer Compounds Ectopically Activate the ClpP Protease and Represent a New Scaffold for Antibiotic Development Academic Article
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Insights in ChAdOx1 nCoV-19 vaccine-induced immune thrombotic thrombocytopenia Academic Article
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Ion occupancy of the channel pore is critical for triggering excitation-transcription (ET) coupling Academic Article
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Long wavelength optical control of glutamate receptor ion channels using a tetra-ortho-substituted azobenzene derivative Academic Article
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Loss-of-function mutations in SIM1 contribute to obesity and Prader-Willi–like features Academic Article
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MBNL proteins repress ES-cell-specific alternative splicing and reprogramming Academic Article
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Mechanism for Selective Synaptic Wiring of Rod Photoreceptors into the Retinal Circuitry and Its Role in Vision Academic Article
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Mechanisms of cytosolic targeting of matrix metalloproteinase-2 Academic Article
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Metabolomic and Genome-wide Association Studies Reveal Potential Endogenous Biomarkers for OATP1B1 Academic Article
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MicroRNAs 146a/b-5 and 425-3p and 24-3p are markers of antidepressant response and regulate MAPK/Wnt-system genes Academic Article
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Modulation of pulmonary fibrosis by IL-13Rα2 Academic Article
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Multilayered Control of Alternative Splicing Regulatory Networks by Transcription Factors Academic Article
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Multiple post-translational modifications regulate E-cadherin transport during apoptosis Academic Article
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Mutations in EBF3 Disturb Transcriptional Profiles and Cause Intellectual Disability, Ataxia, and Facial Dysmorphism Academic Article
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Mutations inSYNGAP1Cause Intellectual Disability, Autism, and a Specific Form of Epilepsy by Inducing Haploinsufficiency Academic Article
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Mutations of AKT3 are associated with a wide spectrum of developmental disorders including extreme megalencephaly Academic Article
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Neuregulin-1 Regulates Cortical Inhibitory Neuron Dendrite and Synapse Growth through DISC1 Academic Article
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New soluble angiopoietin analog of Hepta‐ANG1 prevents pathological vascular leakage Academic Article
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Novel GAA sequence variant c.1211 A>G reduces enzyme activity but not protein expression in infantile and adult onset Pompe disease Academic Article
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Optimal activation of Fc-mediated effector functions by influenza virus hemagglutinin antibodies requires two points of contact Academic Article
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Pre-surgical neoadjuvant oncolytic virotherapy confers protection against rechallenge in a murine model of breast cancer Academic Article
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Preclinical Testing of CAR T Cells in a Patient-Derived Xenograft Model of Glioblastoma Academic Article
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Preclinical evaluation of a SARS-CoV-2 mRNA vaccine PTX-COVID19-B Academic Article
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Preparative separation of monoclonal antibody aggregates by cation-exchange laterally-fed membrane chromatography Academic Article
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Probing ADAMTS13 Substrate Specificity using Phage Display Academic Article
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Propagation of Human Prostate Cancer Stem-Like Cells Occurs through EGFR-Mediated ERK Activation Academic Article
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Protumorigenic effects of mir-145 loss in malignant pleural mesothelioma Academic Article
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Regulation of thrombospondin-1 expression through AU-rich elements in the 3′UTR of the mRNA Academic Article
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Retinoic acid and arsenic trioxide sensitize acute promyelocytic leukemia cells to ER stress Academic Article
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S6K-STING interaction regulates cytosolic DNA–mediated activation of the transcription factor IRF3 Academic Article
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SIPL1 enhances the proliferation, attachment, and migration of CHO cells by inhibiting PTEN function Academic Article
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SIPL1-facilitated PTEN ubiquitination contributes to its association with PTEN Academic Article
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SUMOylation of periplakin is critical for efficient reorganization of keratin filament network Academic Article
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Severe neurocognitive and growth disorders due to variation in THOC2
, an essential component of nuclear mRNA export machinery Academic Article
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Single-site glycine-specific labeling of proteins Academic Article
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Slit/Robo-mediated chemorepulsion of vagal sensory axons in the fetal gut Academic Article
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Structural Basis for Cyclic-Nucleotide Selectivity and cGMP-Selective Activation of PKG I Academic Article
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TRIM26 Facilitates HSV-2 Infection by Downregulating Antiviral Responses through the IRF3 Pathway Academic Article
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Targeted Gene Sequencing Identifies Variants in the Protein C and Endothelial Protein C Receptor Genes in Patients With Unprovoked Venous Thromboembolism Academic Article
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Telomere crisis in kidney epithelial cells promotes the acquisition of a microRNA signature retrieved in aggressive renal cell carcinomas Academic Article
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The Ancient Drug Salicylate Directly Activates AMP-Activated Protein Kinase Academic Article
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The CD200-tolerance Signaling Molecule Associated with Pregnancy Success is Present In Patients with Early-stage Breast Cancer but Does not Favor Nodal Metastasis Academic Article
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The Na+/Glucose Cotransporter Inhibitor Canagliflozin Activates AMPK by Inhibiting Mitochondrial Function and Increasing Cellular AMP Levels Academic Article
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The Phenotypic Spectrum of a Mutation Hotspot Responsible for the Short QT Syndrome Academic Article
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The autophagy initiator ULK1 sensitizes AMPK to allosteric drugs Academic Article
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The carboxyl-terminal sequence of bim enables bax activation and killing of unprimed cells Academic Article
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The chimeric TAC receptor co-opts the T cell receptor yielding robust anti-tumor activity without toxicity Academic Article
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The dual DPP4 inhibitor and GPR119 agonist HBK001 regulates glycemic control and beta cell function ex and in vivo Academic Article
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The huntingtin N17 domain is a multifunctional CRM1 and Ran-dependent nuclear and cilial export signal Academic Article
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The impact of the endothelial protein C receptor on thrombin generation and clot lysis Academic Article
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Truncating Mutations in UBAP1 Cause Hereditary Spastic Paraplegia Academic Article
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USP15 regulates type I interferon response and is required for pathogenesis of neuroinflammation Academic Article
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Unraveling Determinants of Affinity Enhancement in Dimeric Aptamers for a Dimeric Protein Academic Article
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Vero cells gain renal tubule markers in low-calcium and magnesium chemically defined media Academic Article
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Whole exome sequencing reveals a biallelic frameshift mutation in
GRXCR2
in hearing impairment in Cameroon Academic Article
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p75NTR-dependent Rac1 activation requires receptor cleavage and activation of an NRAGE and NEDD9 signaling cascade Academic Article
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β-Catenin Overexpression in the Metanephric Mesenchyme Leads to Renal Dysplasia Genesis via Cell-Autonomous and Non–Cell-Autonomous Mechanisms Academic Article
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β-Subunit of the voltage-gated Ca
2+
channel Cav1.2 drives signaling to the nucleus via H-Ras Academic Article