HEK293 Cells Concept

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• A biallelic pathogenic variant in the OGDH gene results in a neurological disorder with features of a mitochondrial disease  Academic Article
• A dominant autoinflammatory disease caused by non-cleavable variants of RIPK1  Academic Article
• A naturally occurring transcript variant of MARCO reveals the SRCR domain is critical for function  Academic Article
• A rapid in vitro methodology for simultaneous target discovery and antibody generation against functional cell subpopulations  Academic Article
• AAV-mediated expression of 3TSR inhibits tumor and metastatic lesion development and extends survival in a murine model of epithelial ovarian carcinoma  Academic Article
• ARMMs as a versatile platform for intracellular delivery of macromolecules  Academic Article
• ATM and ATR Signaling Regulate the Recruitment of Human Telomerase to Telomeres  Academic Article
• ATM kinase enables the functional axis of YAP, PML and p53 to ameliorate loss of Werner protein-mediated oncogenic senescence  Academic Article
• Active-site mTOR inhibitors augment HSV1-dICP0 infection in cancer cells via dysregulated eIF4E/4E-BP axis  Academic Article
• Alpha-1 proteinase inhibitor M358R reduces thrombin generation when displayed on the surface of cells expressing tissue factor  Academic Article
• Alveolar macrophages are critical for broadly-reactive antibody-mediated protection against influenza A virus in mice  Academic Article
• An Endogenous Reactive Oxygen Species (ROS)-Activated Histone Deacetylase Inhibitor Prodrug for Cancer Chemotherapy  Academic Article
• Analysis of purified Wild type and mutant adenovirus particles by SILAC based quantitative proteomics  Academic Article
• Antibodies Encoded by FCRL4-Bearing Memory B Cells Preferentially Recognize Commensal Microbial Antigens  Academic Article
• Asialoglycoprotein receptor 1 is a novel PCSK9-independent ligand of liver LDLR cleaved by furin  Academic Article
• Autism associated mutations in β2 subunit of voltage-gated calcium channels constitutively activate gene expression  Academic Article
• Base-pair conformational switch modulates miR-34a targeting of Sirt1 mRNA  Academic Article
• Bioinformatic discovery of a toxin family in Chryseobacterium piperi with sequence similarity to botulinum neurotoxins  Academic Article
• Both Neutralizing and Non-Neutralizing Human H7N9 Influenza Vaccine-Induced Monoclonal Antibodies Confer Protection  Academic Article
• CARMA3 Is a Host Factor Regulating the Balance of Inflammatory and Antiviral Responses against Viral Infection  Academic Article
• CYB5D2 displays tumor suppression activities towards cervical cancer  Academic Article
• Calcium as a reliable marker for the quantitative assessment of endoplasmic reticulum stress in live cells  Academic Article
• Characterization of a novel SCN5A genetic variant A1294G associated with mixed clinical phenotype  Academic Article
• Childhood amyotrophic lateral sclerosis caused by excess sphingolipid synthesis  Academic Article
• Clear cell renal cell carcinoma induces fibroblast-mediated production of stromal periostin  Academic Article
• Cockayne syndrome group B protein regulates fork restart, fork progression and MRE11-dependent fork degradation in BRCA1/2-deficient cells  Academic Article
• Common DISC1 Polymorphisms Disrupt Wnt/GSK3β Signaling and Brain Development  Academic Article
• Comparison of mammalian and bacterial expression library screening to detect recombinant alpha-1 proteinase inhibitor variants with enhanced thrombin inhibitory capacity☆  Academic Article
• Comparison of the Proinflammatory and Procoagulant Properties of Nuclear, Mitochondrial, and Bacterial DNA  Academic Article
• Complete Disruption of Autism-Susceptibility Genes by Gene Editing Predominantly Reduces Functional Connectivity of Isogenic Human Neurons  Academic Article
• Congenital myasthenic syndrome–associated agrin variants affect clustering of acetylcholine receptors in a domain-specific manner  Academic Article
• Covalent Immune Recruiters: Tools to Gain Chemical Control Over Immune Recognition  Academic Article
• Cystathionine Protects against Endoplasmic Reticulum Stress-induced Lipid Accumulation, Tissue Injury, and Apoptotic Cell Death  Academic Article
• Discovery of Butyrylcholinesterase-Activated Near-Infrared Fluorogenic Probe for Live-Cell and In Vivo Imaging  Academic Article
• Early evolutionary loss of the lipid A modifying enzyme PagP resulting in innate immune evasion in Yersinia pestis  Academic Article
• Elevated basal transcription can underlie timothy channel association with autism related disorders  Academic Article
• Encephalitis with refractory seizures, status epilepticus, and antibodies to the GABAA receptor: a case series, characterisation of the antigen, and analysis of the effects of antibodies  Academic Article
• Engineered human Tmpk fused with truncated cell-surface markers: versatile cell-fate control safety cassettes  Academic Article
• Evaluation of Genes Encoding for the Transient Outward Current (Ito) Identifies the KCND2 Gene as a Cause of J-Wave Syndrome Associated With Sudden Cardiac Death  Academic Article
• Fine-Tuning of the RIG-I-Like Receptor/Interferon Regulatory Factor 3-Dependent Antiviral Innate Immune Response by the Glycogen Synthase Kinase 3/β-Catenin Pathway  Academic Article
• Functional Effects of Epilepsy Associated KCNT1 Mutations Suggest Pathogenesis via Aberrant Inhibitory Neuronal Activity  Academic Article
• Functional diversification of the NleG effector family in enterohemorrhagic Escherichia coli  Academic Article
• Gain-of-function mutations in IFIH1 cause a spectrum of human disease phenotypes associated with upregulated type I interferon signaling  Academic Article
• HIV-1 gp120 Induces TLR2- and TLR4-Mediated Innate Immune Activation in Human Female Genital Epithelium  Academic Article
• Human-Specific Mutations and Positively Selected Sites in MARCO Confer Functional Changes  Academic Article
• Identification of a Botulinum Neurotoxin-like Toxin in a Commensal Strain of Enterococcus faecium  Academic Article
• Imipridone Anticancer Compounds Ectopically Activate the ClpP Protease and Represent a New Scaffold for Antibiotic Development  Academic Article
• Insights in ChAdOx1 nCoV-19 vaccine-induced immune thrombotic thrombocytopenia  Academic Article
• Ion occupancy of the channel pore is critical for triggering excitation-transcription (ET) coupling  Academic Article
• Long wavelength optical control of glutamate receptor ion channels using a tetra-ortho-substituted azobenzene derivative  Academic Article
• Loss-of-function mutations in SIM1 contribute to obesity and Prader-Willi–like features  Academic Article
• MBNL proteins repress ES-cell-specific alternative splicing and reprogramming  Academic Article
• Mechanism for Selective Synaptic Wiring of Rod Photoreceptors into the Retinal Circuitry and Its Role in Vision  Academic Article
• Mechanisms of cytosolic targeting of matrix metalloproteinase-2  Academic Article
• Metabolomic and Genome-wide Association Studies Reveal Potential Endogenous Biomarkers for OATP1B1  Academic Article
• MicroRNAs 146a/b-5 and 425-3p and 24-3p are markers of antidepressant response and regulate MAPK/Wnt-system genes  Academic Article
• Modulation of pulmonary fibrosis by IL-13Rα2  Academic Article
• Multilayered Control of Alternative Splicing Regulatory Networks by Transcription Factors  Academic Article
• Multiple post-translational modifications regulate E-cadherin transport during apoptosis  Academic Article
• Mutations in EBF3 Disturb Transcriptional Profiles and Cause Intellectual Disability, Ataxia, and Facial Dysmorphism  Academic Article
• Mutations inSYNGAP1Cause Intellectual Disability, Autism, and a Specific Form of Epilepsy by Inducing Haploinsufficiency  Academic Article
• Mutations of AKT3 are associated with a wide spectrum of developmental disorders including extreme megalencephaly  Academic Article
• Neuregulin-1 Regulates Cortical Inhibitory Neuron Dendrite and Synapse Growth through DISC1  Academic Article
• New soluble angiopoietin analog of Hepta‐ANG1 prevents pathological vascular leakage  Academic Article
• Novel GAA sequence variant c.1211 A>G reduces enzyme activity but not protein expression in infantile and adult onset Pompe disease  Academic Article
• Optimal activation of Fc-mediated effector functions by influenza virus hemagglutinin antibodies requires two points of contact  Academic Article
• Pre-surgical neoadjuvant oncolytic virotherapy confers protection against rechallenge in a murine model of breast cancer  Academic Article
• Preclinical Testing of CAR T Cells in a Patient-Derived Xenograft Model of Glioblastoma  Academic Article
• Preclinical evaluation of a SARS-CoV-2 mRNA vaccine PTX-COVID19-B  Academic Article
• Preparative separation of monoclonal antibody aggregates by cation-exchange laterally-fed membrane chromatography  Academic Article
• Probing ADAMTS13 Substrate Specificity using Phage Display  Academic Article
• Propagation of Human Prostate Cancer Stem-Like Cells Occurs through EGFR-Mediated ERK Activation  Academic Article
• Protumorigenic effects of mir-145 loss in malignant pleural mesothelioma  Academic Article
• Regulation of thrombospondin-1 expression through AU-rich elements in the 3′UTR of the mRNA  Academic Article
• Retinoic acid and arsenic trioxide sensitize acute promyelocytic leukemia cells to ER stress  Academic Article
• S6K-STING interaction regulates cytosolic DNA–mediated activation of the transcription factor IRF3  Academic Article
• SIPL1 enhances the proliferation, attachment, and migration of CHO cells by inhibiting PTEN function  Academic Article
• SIPL1-facilitated PTEN ubiquitination contributes to its association with PTEN  Academic Article
• SUMOylation of periplakin is critical for efficient reorganization of keratin filament network  Academic Article
• Severe neurocognitive and growth disorders due to variation in THOC2 , an essential component of nuclear mRNA export machinery  Academic Article
• Single-site glycine-specific labeling of proteins  Academic Article
• Slit/Robo-mediated chemorepulsion of vagal sensory axons in the fetal gut  Academic Article
• Structural Basis for Cyclic-Nucleotide Selectivity and cGMP-Selective Activation of PKG I  Academic Article
• TRIM26 Facilitates HSV-2 Infection by Downregulating Antiviral Responses through the IRF3 Pathway  Academic Article
• Targeted Gene Sequencing Identifies Variants in the Protein C and Endothelial Protein C Receptor Genes in Patients With Unprovoked Venous Thromboembolism  Academic Article
• Telomere crisis in kidney epithelial cells promotes the acquisition of a microRNA signature retrieved in aggressive renal cell carcinomas  Academic Article
• The Ancient Drug Salicylate Directly Activates AMP-Activated Protein Kinase  Academic Article
• The CD200-tolerance Signaling Molecule Associated with Pregnancy Success is Present In Patients with Early-stage Breast Cancer but Does not Favor Nodal Metastasis  Academic Article
• The Na+/Glucose Cotransporter Inhibitor Canagliflozin Activates AMPK by Inhibiting Mitochondrial Function and Increasing Cellular AMP Levels  Academic Article
• The Phenotypic Spectrum of a Mutation Hotspot Responsible for the Short QT Syndrome  Academic Article
• The autophagy initiator ULK1 sensitizes AMPK to allosteric drugs  Academic Article
• The carboxyl-terminal sequence of bim enables bax activation and killing of unprimed cells  Academic Article
• The chimeric TAC receptor co-opts the T cell receptor yielding robust anti-tumor activity without toxicity  Academic Article
• The dual DPP4 inhibitor and GPR119 agonist HBK001 regulates glycemic control and beta cell function ex and in vivo  Academic Article
• The huntingtin N17 domain is a multifunctional CRM1 and Ran-dependent nuclear and cilial export signal  Academic Article
• The impact of the endothelial protein C receptor on thrombin generation and clot lysis  Academic Article
• Truncating Mutations in UBAP1 Cause Hereditary Spastic Paraplegia  Academic Article
• USP15 regulates type I interferon response and is required for pathogenesis of neuroinflammation  Academic Article
• Unraveling Determinants of Affinity Enhancement in Dimeric Aptamers for a Dimeric Protein  Academic Article
• Vero cells gain renal tubule markers in low-calcium and magnesium chemically defined media  Academic Article
• Whole exome sequencing reveals a biallelic frameshift mutation in GRXCR2 in hearing impairment in Cameroon  Academic Article
• p75NTR-dependent Rac1 activation requires receptor cleavage and activation of an NRAGE and NEDD9 signaling cascade  Academic Article
• β-Catenin Overexpression in the Metanephric Mesenchyme Leads to Renal Dysplasia Genesis via Cell-Autonomous and Non–Cell-Autonomous Mechanisms  Academic Article
• β-Subunit of the voltage-gated Ca ²⁺ channel Cav1.2 drives signaling to the nucleus via H-Ras  Academic Article