Journal article
Proapelin is processed extracellularly in a cell line-dependent manner with clear modulation by proprotein convertases
Abstract
Apelin is a peptide hormone that binds to a class A GPCR (the apelin receptor/APJ) to regulate various bodily systems. Upon signal peptide removal, the resulting 55-residue isoform, proapelin/apelin-55, can be further processed to 36-, 17-, or 13-residue isoforms with length-dependent pharmacological properties. Processing was initially proposed to occur intracellularly. However, detection of apelin-55 in extracellular fluids indicates that …
Authors
Shin K; Landsman M; Pelletier S; Alamri BN; Anini Y; Rainey JK
Journal
Amino Acids, Vol. 51, No. 3, pp. 395–405
Publisher
Springer Nature
Publication Date
March 7, 2019
DOI
10.1007/s00726-018-2674-8
ISSN
0939-4451