Journal article
In vitro and in vivo toxicity of thiolated and PEGylated organosilica nanoparticles
Abstract
This study comprises the comprehensive toxicological assessment of thiolated organosilica nanoparticles (NPs) synthesised from 3-mercaptopropyltrimethoxysilane (MPTS). We investigated the influence of three different types of nanoparticles synthesised from 3-mercaptopropyltrimethoxysilane: the starting thiolated silica (Si-NP-SH) and their derivatives prepared by surface PEGylation with PEG 750 (Si-NP-PEG750) and 5000 Da (Si-NP-PEG5000) on …
Authors
Zhaisanbayeva BA; Mun EA; Ulmanova L; Zhunissova Z; Umbayev B; Olzhayev F; Vorobjev IA; Hortelano G; Khutoryanskiy VV
Journal
International Journal of Pharmaceutics, Vol. 652, ,
Publisher
Elsevier
Publication Date
March 2024
DOI
10.1016/j.ijpharm.2024.123852
ISSN
0378-5173