Metabolomic and Genome‐wide Association Studies...

Abstract

Transporter-mediated drug-drug interactions (DDIs) are a major cause of drug toxicities. Using published genome-wide association studies (GWAS) of the human metabolome, we identified 20 metabolites associated with genetic variants in organic anion transporter, OATP1B1 (P < 5 × 10^-8 ). Of these, 12 metabolites were significantly higher in plasma samples from volunteers dosed with the OATP1B1 inhibitor, cyclosporine (CSA) vs. placebo (q-value < …

Authors

Yee S; Giacomini M; Hsueh C; Weitz D; Liang X; Goswami S; Kinchen J; Coelho A; Zur A; Mertsch K

Journal

Clinical Pharmacology & Therapeutics, Vol. 100, No. 5, pp. 524–536

Publisher

Wiley

Publication Date

November 2016

DOI

10.1002/cpt.434

ISSN

0009-9236

Associated Experts

Mita Giacomini

Professor Emeritus, Faculty of Health Sciences

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Labels

Fields of Research (FoR)

3205 Medical Biochemistry and Metabolomics 3214 Pharmacology and pharmaceutical sciences 32 Biomedical and Clinical Sciences

Medical Subject Headings (MeSH)

Bile Acids and Salts Biomarkers Cyclosporine Dicarboxylic Acids Drug Interactions Fatty Acids Genome-Wide Association Study HEK293 Cells Humans Liver-Specific Organic Anion Transporter 1 Metabolomics Myristates Organic Anion Transport Protein 1 Organic Anion Transporters, Sodium-Independent Palmitic Acids Pravastatin

Metabolomic and Genome‐wide Association Studies Reveal Potential Endogenous Biomarkers for OATP1B1