Journal article
Preclinical Testing of CAR T Cells in a Patient-Derived Xenograft Model of Glioblastoma
Abstract
Glioblastoma (GBM) is the most common malignant adult brain tumor that is resistant to the standard care therapy. Advances in chimeric antigen receptor (CAR) T cell therapies have spurred renewed interest in developing CAR T cell therapies to target chemoradiotherapy-resistant brain tumor-initiating cells. This protocol shows how to isolate peripheral blood mononuclear cells from healthy donors and generate CAR T cells for the antigens of …
Authors
Tatari N; Maich WT; Salim SK; Mckenna D; Venugopal C; Singh S
Journal
STAR Protocols, Vol. 1, No. 3,
Publisher
Elsevier
Publication Date
December 2020
DOI
10.1016/j.xpro.2020.100174
ISSN
2666-1667