Antibodies Encoded by FCRL4-Bearing Memory B Cells Preferentially Recognize Commensal Microbial Antigens Academic Article uri icon

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abstract

  • FCRL4, a low-affinity IgA Ab receptor with strong immunoregulatory potential, is an identifying feature of a tissue-based population of memory B cells (Bmem). We used two independent approaches to perform a comparative analysis of the Ag receptor repertoires of FCRL4+ and FCRL4- Bmem in human tonsils. We determined that FCRL4+ Bmem displayed lower levels of somatic mutations in their Ag receptors compared with FCRL4- Bmem but had similar frequencies of variable gene family usage. Importantly, Abs with reactivity to commensal microbiota were enriched in FCRL4+ cells, a phenotype not due to polyreactive binding characteristics. Our study links expression of the immunoregulatory FCRL4 molecule with increased recognition of commensal microbial Ags.

authors

  • Liu, Yanling
  • McDaniel, Jonathan R
  • Khan, Srijit
  • Campisi, Paolo
  • Propst, Evan J
  • Holler, Theresa
  • Grunebaum, Eyal
  • Georgiou, George
  • Ippolito, Gregory C
  • Ehrhardt, Götz RA

publication date

  • June 15, 2018