Biochemistry Journal

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• The Janus Effect: The Biochemical Logic of Antibiotic Resistance..  64:301-311. 2025
• Role of Half-of-Sites Reactivity and Inter-Subunit Communications in DAHP Synthase Catalysis and Regulation.  61:2229-2240. 2022
• Structural Basis of Stereospecific Vanadium-Dependent Haloperoxidase Family Enzymes in Napyradiomycin Biosynthesis.  61:1844-1852. 2022
• Covalent Stabilization of Antibody Recruitment Enhances Immune Recognition of Cancer Targets.  60:1447-1458. 2021
• NeuNAc Oxime: A Slow-Binding and Effectively Irreversible Inhibitor of the Sialic Acid Synthase NeuB.  58:4236-4245. 2019
• Eliminating Competition: Characterizing and Eliminating Competitive Binding at Separate Sites between DAHP Synthase’s Essential Metal Ion and the Inhibitor DAHP Oxime.  57:6679-6687. 2018
• Campylobacter jejuni KDO8P Synthase, Its Inhibition by KDO8P Oxime, and Control of the Residence Time of Slow-Binding Inhibition.  57:5327-5338. 2018
• Exosite 2-Directed Ligands Attenuate Protein C Activation by the Thrombin–Thrombomodulin Complex.  56:3119-3128. 2017
• Linear Free Energy Relationship Analysis of Transition State Mimicry by 3-Deoxy-d-arabino-heptulosonate-7-phosphate (DAHP) Oxime, a DAHP Synthase Inhibitor and Phosphate Mimic.  56:592-601. 2017
• Potent Inhibition of 3-Deoxy-d-arabinoheptulosonate-7-phosphate (DAHP) Synthase by DAHP Oxime, a Phosphate Group Mimic.  55:6617-6629. 2016
• Diacylglycerol Kinase Delta Promotes Lipogenesis.  52:7766-7776. 2013
• Functional Mapping of PilF and PilQ in the Pseudomonas aeruginosa Type IV Pilus System.  52:2914-2923. 2013
• By Increasing the Affinity of Heparin for Fibrin, Zn²⁺ Promotes the Formation of a Ternary Heparin–Thrombin–Fibrin Complex That Protects Thrombin from Inhibition by Antithrombin.  51:7964-7973. 2012
• Functional Screening of Pharmacological Chaperones via Restoration of Enzyme Activity upon Denaturation.  51:7651-7653. 2012
• Concentration-Dependent Structural Transitions of Human Telomeric DNA Sequences.  51:7357-7366. 2012
• Type IV Secretion System Core Component VirB8 from Brucella Binds to the Globular Domain of VirB5 and to a Periplasmic Domain of VirB6.  51:3881-3890. 2012
• Modifications in Perfringolysin O Domain 4 Alter the Cholesterol Concentration Threshold Required for Binding.  51:3373-3382. 2012
• Mechanism and Diversity of the Erythromycin Esterase Family of Enzymes.  51:1740-1751. 2012
• Lyme Disease Enolpyruvyl-UDP-GlcNAc Synthase: Fosfomycin-Resistant MurA from Borrelia burgdorferi, a Fosfomycin-Sensitive Mutant, and the Catalytic Role of the Active Site Asp.  50:2205-2212. 2011
• Inscribing the Perimeter of the PagP Hydrocarbon Ruler by Site-Specific Chemical Alkylation.  49:9046-9057. 2010
• Probing the Function of Nucleotides in the Catalytic Cores of the 8−17 and 10−23 DNAzymes by Abasic Nucleotide and C3 Spacer Substitutions.  49:7553-7562. 2010
• A Thiolate Anion Buried within the Hydrocarbon Ruler Perturbs PagP Lipid Acyl Chain Selection.  49:2368-2379. 2010
• Structural and Kinetic Characterization of the LPS Biosynthetic Enzyme d-α,β-d-Heptose-1,7-bisphosphate Phosphatase (GmhB) from Escherichia coli,.  49:1033-1041. 2010
• Evidence of Kinetic Control of Ligand Binding and Staged Product Release in MurA (Enolpyruvyl UDP-GlcNAc Synthase)-Catalyzed Reactions,.  48:11715-11723. 2009
• Molecular Mechanism for Lateral Lipid Diffusion between the Outer Membrane External Leaflet and a β-Barrel Hydrocarbon Ruler.  48:9745-9756. 2009
• Characterization of an RNA-Cleaving Deoxyribozyme with Optimal Activity at pH 5.  48:7383-7391. 2009
• Allosteric Site Variants of Haemophilus influenzae β-Carbonic Anhydrase.  48:6146-6156. 2009
• Catalytic Residues and an Electrostatic Sandwich That Promote Enolpyruvyl Shikimate 3-Phosphate Synthase (AroA) Catalysis.  48:3699-3707. 2009
• Early Intraplatelet Signaling Enhances the Release of Human Platelet PAR-1 and -4 Amino-Terminal Peptides in Response to Thrombin.  48:1562-1572. 2009
• Label-Free Assay for Thermodynamic Analysis of Protein−Ligand Interactions: A Multivariate Strategy for Allosteric Ligand Screening.  48:223-225. 2009
• Substrate Chirality and Specificity of Diacylglycerol Kinases and the Multisubstrate Lipid Kinase.  46:14225-14231. 2007
• Mechanistic Studies on Norcoclaurine Synthase of Benzylisoquinoline Alkaloid Biosynthesis:  An Enzymatic Pictet−Spengler Reaction.  46:10153-10161. 2007
• Role of the Hydrophobic Segment of Diacylglycerol Kinase ε.  46:6109-6117. 2007
• Gauging a Hydrocarbon Ruler by an Intrinsic Exciton Probe.  46:4565-4579. 2007
• In the Presence of Phospholipids, Glycosaminoglycans Potentiate Factor Xa-Mediated Protein C Activation by Modulating Factor Xa Activity.  46:4195-4203. 2007
• Enolpyruvyl Activation by Enolpyruvylshikimate-3-phosphate Synthase.  46:1933-1940. 2007
• Multiple Occurrences of an Efficient Self-Phosphorylating Deoxyribozyme Motif.  46:2198-2204. 2007
• Comparison of Solution Structures and Stabilities of Native, Partially Unfolded and Partially Refolded Pepsin.  45:13982-13992. 2006
• The Transferable Tail:  Fusion of the N-Terminal Acidic Extension of Heparin Cofactor II to α₁-Proteinase Inhibitor M358R Specifically Increases the Rate of Thrombin Inhibition.  45:11444-11452. 2006
• Phosphate Analogues as Probes of the Catalytic Mechanisms of MurA and AroA, Two Carboxyvinyl Transferases.  45:6027-6037. 2006
• Incorporation of Fragment X into Fibrin Clots Renders Them More Susceptible to Lysis by Plasmin.  45:4257-4265. 2006
• Factor XIIIa Mediated Attachment of S. aureus Fibronectin-Binding Protein A (FnbA) to Fibrin:  Identification of Gln103 as a Major Cross-Linking Site.  45:1870-1880. 2006
• Crystal Structure of Homoserine Transacetylase from Haemophilus influenzae Reveals a New Family of α/β-Hydrolases^,.  44:15768-15773. 2005
• Catalytic Mechanism of Fungal Homoserine Transacetylase.  44:13560-13566. 2005
• Chemoenzymatic Synthesis of Cryptophycin/Arenastatin Natural Products.  44:13457-13466. 2005
• Characterizing the Secondary Structure and Identifying Functionally Essential Nucleotides of pH6DZ1, a Fluorescence-Signaling and RNA-Cleaving Deoxyribozyme.  44:12066-12076. 2005
• Establishing the Principles of Recognition in the Adenine-Binding Region of an Aminoglycoside Antibiotic Kinase [APH(3‘)-IIIa].  44:12445-12453. 2005
• Tigecycline Is Modified by the Flavin-Dependent Monooxygenase TetX.  44:11829-11835. 2005
• Mapping of Steroids Binding to 17β-Hydroxysteroid Dehydrogenase Type 1 Using Monte Carlo Energy Minimization Reveals Alternative Binding Modes.  44:7218-7227. 2005
• Secondary-Structure Characterization of Two Proficient Kinase Deoxyribozymes.  44:3765-3774. 2005
• UDP-N-acetylmuramic Acid (UDP-MurNAc) Is a Potent Inhibitor of MurA (Enolpyruvyl-UDP-GlcNAc Synthase).  44:4011-4017. 2005
• Dynamics of the Fragment of Thrombomodulin Containing the Fourth and Fifth Epidermal Growth Factor-like Domains Correlate with Function.  44:1225-1233. 2005
• Ionic Mobilities of Duplex and Frayed Wire DNA in Discontinuous Buffer Electrophoresis:  Evidence of Interactions with Amino Acids.  43:16337-16347. 2004
• Full or Partial Substitution of the Reactive Center Loop of α-1-Proteinase Inhibitor by that of Heparin Cofactor II:  P1 Arg Is Required for Maximal Thrombin Inhibition.  43:14864-14872. 2004
• The Role of Ca²⁺-Coordinating Residues of Herring Antifreeze Protein in Antifreeze Activity.  43:14547-14554. 2004
• Bifunctional Catalysis by CDP-ribitol Synthase:  Convergent Recruitment of Reductase and Cytidylyltransferase Activities in Haemophilus influenzae and Staphylococcus aureus.  43:11802-11812. 2004
• Domain−Domain Interactions in the Aminoglycoside Antibiotic Resistance Enzyme AAC(6‘)-APH(2‘ ‘).  43:9846-9855. 2004
• Tracing Sequence Diversity Change of RNA-Cleaving Deoxyribozymes under Increasing Selection Pressure during in Vitro Selection.  43:9695-9707. 2004
• An Apolipoprotein AI Mimetic Peptide:  Membrane Interactions and the Role of Cholesterol^,.  43:5073-5083. 2004
• Overexpression of the Endoplasmic Reticulum 60 Protein ER-60 Downregulates ApoB100 Secretion by Inducing Its Intracellular Degradation via a Nonproteasomal Pathway:  Evidence for an ER-60-Mediated and pCMB-Sensitive Intracellular Degradative Pathway.  43:4819-4831. 2004
• Molecular Mechanism of the Enterococcal Aminoglycoside 6‘-N-Acetyltransferase‘:  Role of GNAT-Conserved Residues in the Chemistry of Antibiotic Inactivation.  43:446-454. 2004
• Staphylococcus aureus Fibronectin-Binding Protein Serves as a Substrate for Coagulation Factor XIIIa:  Evidence for Factor XIIIa-Catalyzed Covalent Cross-Linking to Fibronectin and Fibrin.  42:14643-14652. 2003
• Glycosaminoglycans Bind Factor Xa in a Ca²⁺-Dependent Fashion and Modulate Its Catalytic Activity.  42:13091-13098. 2003
• NMR Structures Reveal How Oxidation Inactivates Thrombomodulin.  42:11932-11942. 2003
• Identification of the catalytic residues of AroA (Enolpyruvylshikimate 3-phosphate synthase) using partitioning analysis.  42:6986-6995. 2003
• Kinetic mechanism of the GCN5-related chromosomal aminoglycoside acetyltransferase AAC(6')-Ii from Enterococcus faecium: evidence of dimer subunit cooperativity.  42:6565-6574. 2003
• Identification of the Catalytic Residues of AroA (Enolpyruvylshikimate 3-Phosphate Synthase) Using Partitioning Analysis.  42:6986-6995. 2003
• Surface Denaturation and Amyloid Fibril Formation of Insulin at Model Lipid−Water Interfaces.  41:15810-15819. 2002
• YjeQ, an Essential, Conserved, Uncharacterized Protein from Escherichia coli, Is an Unusual GTPase with Circularly Permuted G-Motifs and Marked Burst Kinetics.  41:11109-11117. 2002
• Mechanism of aminoglycoside antibiotic kinase APH(3')-IIIa: role of the nucleotide positioning loop.  41:7001-7007. 2002
• NMR Structure of the Second Intracellular Loop of the α2A Adrenergic Receptor:  Evidence for a Novel Cytoplasmic Helix^,.  41:3596-3604. 2002
• Pentavalent Ions Dependency Is a Conserved Property of Adenosine Kinase from Diverse Sources:  Identification of a Novel Motif Implicated in Phosphate and Magnesium Ion Binding and Substrate Inhibition.  41:4059-4069. 2002
• Conformational Dimorphism and Transmembrane Orientation of Prion Protein Residues 110−136 in Bicelles.  40:13137-13142. 2001
• Vgb from Staphylococcus aureus inactivates streptogramin B antibiotics by an elimination mechanism not hydrolysis.  40:8877-8886. 2001
• Reduction Precedes Cytidylyl Transfer without Substrate Channeling in Distinct Active Sites of the Bifunctional CDP-Ribitol Synthase from Haemophilus influenzae.  40:5041-5048. 2001
• High-level expression and mutagenesis of recombinant human phosphatidylcholine transfer protein using a synthetic gene: evidence for a C-terminal membrane binding domain..  39:15399-15409. 2000
• Capping DNA with DNA.  39:3106-3114. 2000
• Molecular mechanism of VanHst, an alpha-ketoacid dehydrogenase required for glycopeptide antibiotic resistance from a glycopeptide producing organism.  38:8485-8491. 1999
• The Solution Structure and Dynamics of an Arc Repressor Mutant Reveal Premelting Conformational Changes Related to DNA Binding.  38:6035-6042. 1999
• The Chirality of Phosphatidylserine and the Activation of Protein Kinase C.  37:12068-12073. 1998
• An AP-1 Site in the Nerve Growth Factor Promoter Is Essential for 1,25-Dihydroxyvitamin D₃-Mediated Nerve Growth Factor Expression in Osteoblasts.  37:5988-5994. 1998
• Solution Studies of Isepamicin and Conformational Comparisons between Isepamicin and Butirosin A When Bound to an Aminoglycoside 6‘-N-Acetyltransferase Determined by NMR Spectroscopy.  37:3638-3644. 1998
• The Ice-Binding Site of Atlantic Herring Antifreeze Protein Corresponds to the Carbohydrate-Binding Site of C-Type Lectins.  37:4080-4085. 1998
• Transition-State Structure for the ADP-Ribosylation of Recombinant G_iα1 Subunits by Pertussis Toxin.  37:2748-2758. 1998
• gem-Dialkyl Succinic Acids:  A Novel Class of Inhibitors for Carboxypeptidases.  36:8710-8715. 1997
• Collagen-Based Structures Containing the Peptoid Residue N-Isobutylglycine (Nleu):  Conformational Analysis of Gly-Nleu-Pro Sequences by ¹H-NMR and Molecular Modeling.  36:8725-8732. 1997
• Collagen-Based Structures Containing the Peptoid ResidueN-Isobutylglycine (Nleu):  Synthesis and Biophysical Studies of Gly-Nleu-Pro Sequences by Circular Dichroism and Optical Rotation.  36:8716-8724. 1997
• Evidence for Multiple Mechanisms for Membrane Binding and Integration via Carboxyl-Terminal Insertion Sequences.  36:8873-8882. 1997
• Toward an Efficient DNAzyme.  36:5589-5599. 1997
• Multiconformational NMR Analysis of Sandostatin (Octreotide):  Equilibrium between β-Sheet and Partially Helical Structures^,.  36:1233-1241. 1997
• Acetyltransfer Precedes Uridylyltransfer in the Formation of UDP-N-acetylglucosamine in Separable Active Sites of the Bifunctional GlmU Protein of Escherichia coli.  35:579-585. 1996
• Catalytic Mechanism of Enterococcal Kanamycin Kinase (APH(3‘)-IIIa):  Viscosity, Thio, and Solvent Isotope Effects Support a Theorell−Chance Mechanism.  35:8680-8685. 1996
• Recognition of Anionic Porphyrins by DNA Aptamers.  35:6911-6922. 1996
• Regiospecificity of Aminoglycoside Phosphotransferase from Enterococci and Staphylococci (APH(3‘)-IIIa).  35:8686-8695. 1996
• Overexpression, Purification, and Characterization of VanX, a D-, D-Dipeptidase which Is Essential for Vancomycin Resistance in Enterococcus faecium BM4147.  34:2455-2463. 1995
• Active-Site Labeling of an Aminoglycoside Antibiotic Phosphotransferase (APH(3')-IIIa).  33:14115-14120. 1994
• Detection and Characterization of a Phospholactoyl-Enzyme Adduct in the Reaction Catalyzed by UDP-N-acetylglucosamine Enolpyruvoyl Transferase, MurZ.  33:10638-10645. 1994
• Kinetics, Stoichiometry, and Identification of the Reactive Thiolate in the Inactivation of UDP-GlcNAc Enolpyruvoyl Transferase by the Antibiotic Fosfomycin.  33:10646-10651. 1994
• Broad Spectrum Aminoglycoside Phosphotransferase Type III from Enterococcus: Overexpression, Purification, and Substrate Specificity.  33:6936-6944. 1994
• Modularity of protein function: Chimeric interleukin 1.beta.s containing specific protease inhibitor loops retain function of both molecules.  32:5327-5331. 1993
• Purification and characterization of VanR and the cytosolic domain of VanS: A two-component regulatory system required for vancomycin resistance in Enterococcus faecium BM4147.  32:5057-5063. 1993
• Calcium binding and translocation properties of glucagon and its fragments.  32:1632-1640. 1993
• Molecular basis for vancomycin resistance in Enterococcus faecium BM4147: biosynthesis of a depsipeptide peptidoglycan precursor by vancomycin resistance proteins VanH and VanA.  30:10408-10415. 1991
• .beta.-NGF-endopeptidase: structure and activity of a kallikrein encoded by the gene mGK-22.  30:3443-3450. 1991
• Cooperativity of papain-substrate interaction energies in the S2 to S2' subsites.  30:1394-1402. 1991
• Pulmonary surfactant-associated protein A enhances the surface activity of lipid extract surfactant and reverses inhibition by blood proteins in vitro.  29:8424-8429. 1990
• Activation of Escherichia coli F1-ATPase by lauryldimethylamine oxide and ethylene glycol: relationship of ATPase activity to the interaction of the .epsilon. and .beta. subunits.  29:4335-4340. 1990
• The high molecular weight nerve growth factor complex from Mastomys natalensis differs from the murine nerve growth factor complex.  27:6686-6692. 1988
• Multiple sites and synergism in the binding of inhibitors to microsomal aminopeptidase.  27:3613-3617. 1988
• .epsilon. Subunit of Escherichia coli F1-ATPase: effects on affinity for aurovertin and inhibition of product release in unisite ATP hydrolysis.  26:4488-4493. 1987
• Ligand interactions at the active site of aspartate transcarbamoylase from Escherichia coli.  25:1605-1611. 1986
• Conformations of bound nucleoside triphosphate effectors in aspartate transcarbamylase. Evidence for the London-Schmidt model by transferred nuclear Overhauser effects.  24:1593-1598. 1985
• Analysis of an allosteric binding site: the nucleoside inhibitor site of phosphorylase a.  21:2036-2048. 1982
• Mutants of CHO cells resistant to the protein synthesis inhibitors, cryptopleurine and tylocrebrine: genetic and biochemical evidence for common site of action of emetine, cryptopleurine, tylocrebrine, and tubulosine.  16:3209-3214. 1977
• Effects of subunit interactions on the activity of lactate dehydrogenase studied in immobilized enzyme systems.  15:4215-4222. 1976
• The regulation of protein synthesis in animal cells by serum factors.  15:1375-1381. 1976
• Unusual difference spectra of proteins containing tryptophan. I. Studies with model compounds..  8:3717-3723. 1969
• Unusual difference spectra of proteins containing tryptophan. II. Studies with proteins..  8:3723-3728. 1969
• Correction - A Method for the Complete S Sulfonation of Cysteine Residues in Proteins.  8:2226-2226. 1969
• Complete S-sulfonation of cysteine residues in proteins.  7:4247-4254. 1968
• Studies on the Nature of Chloroplast Lamellae. II. Chemical Composition and Further Physical Properties of Two Chlorophyll-Protein Complexes^*.  6:2006-2014. 1967
• The in Vivo Metabolism of 16α-Hydroxydehydroisoandrosterone in Man^*.  6:2040-2052. 1967

has subject area

• 0304 Medicinal and Biomolecular Chemistry (FoR)
• 0601 Biochemistry and Cell Biology (FoR)
• 1101 Medical Biochemistry and Metabolomics (FoR)
• Biochemistry & Molecular Biology (Science Metrix)

Identity

International Standard Serial Number (ISSN)

• 0006-2960

Electronic International Standard Serial Number (EISSN)

• 1520-4995