Journal article
Multiconformational NMR Analysis of Sandostatin (Octreotide): Equilibrium between β-Sheet and Partially Helical Structures † , ‡
Abstract
This paper reports a detailed conformational analysis by 1H NMR (DMSO-d6, 300 K) and molecular modeling of the octapeptide D-Phe1-Cys2-Phe3-D-Trp4-Lys5-Thr6-Cys7+ ++-Thr8-ol (disulfide bridged) known as sandostatin (or SMS 201-995 or octreotide) with both somatostatin-like and opioid-like bioactivities. This is the initial report on sandostatin showing that attempts to explain all NMR data using a single average conformation reveal several …
Authors
Melacini G; Zhu Q; Goodman M
Journal
Biochemistry, Vol. 36, No. 6, pp. 1233–1241
Publisher
American Chemical Society (ACS)
Publication Date
February 1, 1997
DOI
10.1021/bi962497o
ISSN
0006-2960