Journal article
gem-Dialkyl Succinic Acids: A Novel Class of Inhibitors for Carboxypeptidases †
Abstract
gem-Dimethylsuccinic acid and its higher homolog, 2-methyl-2-ethylsuccinic acid (MESA) are highly potent inhibitors of both carboxypeptidase A (CPA) and B. The inhibition constant of MESA for CPA (0.11 microM for the racemic mixture) is remarkable considering the relatively simple structure of the compound. The molecular feature which is crucial for high affinity binding to both carboxypeptidases appears to be the nonpolar gem-dialkyl locus. …
Authors
Asante-Appiah E; Seetharaman J; Sicheri F; Yang DS-C; Chan WW-C
Journal
Biochemistry, Vol. 36, No. 29, pp. 8710–8715
Publisher
American Chemical Society (ACS)
Publication Date
July 1, 1997
DOI
10.1021/bi970354b
ISSN
0006-2960