selected scholarly activity
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academic article
- Thrombopoietin levels in Quebec platelet disorder-Implications for the mechanism of thrombocytopenia.. Clinical and Laboratory Haematology International Journal of Laboratory Hematology. 40:e33-e34. 2018
- Electron microscopy examination of platelet whole mount preparations to quantitate platelet dense granule numbers: Implications for diagnosing suspected platelet function disorders due to dense granule deficiency.. Clinical and Laboratory Haematology International Journal of Laboratory Hematology. 2018
- Molecular phenotype and bleeding risks of an inherited platelet disorder in a family with a RUNX1 frameshift mutation.. Haemophilia. 23:e204-e213. 2017
- Update from the President on the International Society for Laboratory Hematology, including initiatives to promote education and best practices.. Clinical and Laboratory Haematology International Journal of Laboratory Hematology. 39 Suppl 1:4-5. 2017
- The duplication mutation of Quebec platelet disorder dysregulates PLAU, but not C10orf55, selectively increasing production of normal PLAU transcripts by megakaryocytes but not granulocytes.. PLoS One. 12:e0173991. 2017
- Variability in platelet dense granule adenosine triphosphate release findings amongst patients tested multiple times as part of an assessment for a bleeding disorder.. Clinical and Laboratory Haematology International Journal of Laboratory Hematology. 38:648-657. 2016
- An Assessment of the State of Current Practice in Coagulation Laboratories.. American Journal of Clinical Pathology. 146:378-383. 2016
- The functions of the A1A2A3 domains in von Willebrand factor include multimerin 1 binding.. Thrombosis and Haemostasis. 116:87-95. 2016
- Report on the International Society for Laboratory Hematology Survey on guidelines to support clinical hematology laboratory practice.. Clinical and Laboratory Haematology International Journal of Laboratory Hematology. 38 Suppl 1:133-138. 2016
- New perspectives: the President's update on the International Society for Laboratory Hematology.. Clinical and Laboratory Haematology International Journal of Laboratory Hematology. 38:3-4. 2016
- Assembly and evaluation of an inventory of guidelines that are available to support clinical hematology laboratory practice.. Clinical and Laboratory Haematology International Journal of Laboratory Hematology. 37 Suppl 1:36-45. 2015
- Diagnosis of suspected inherited platelet function disorders: results of a worldwide survey.. Journal of Thrombosis and Haemostasis. 12:1562-1569. 2014
- Evaluation of an automated method for measuring von Willebrand factor activity in clinical samples without ristocetin.. Clinical and Laboratory Haematology International Journal of Laboratory Hematology. 36:341-351. 2014
- Technological advances in diagnostic testing for von Willebrand disease: new approaches and challenges.. Clinical and Laboratory Haematology International Journal of Laboratory Hematology. 36:334-340. 2014
- Factor XIII Assays and associated problems for laboratory diagnosis of factor XIII deficiency: an analysis of International Proficiency testing results.. Seminars in Thrombosis and Hemostasis. 40:232-238. 2014
- Improving blood disorder diagnosis: reflections on the challenges.. Clinical and Laboratory Haematology International Journal of Laboratory Hematology. 35:244-253. 2013
- Laboratory testing for bleeding disorders: strategic uses of high and low-yield tests.. Clinical and Laboratory Haematology International Journal of Laboratory Hematology. 35:322-333. 2013
- Recommendations for the Standardization of Light Transmission Aggregometry: A Consensus of the Working Party from the Platelet Physiology Subcommittee of SSC/ISTH.. Journal of Thrombosis and Haemostasis. 11:1183-1189. 2013
- Genetic loci associated with platelet traits and platelet disorders.. Seminars in Thrombosis and Hemostasis. 39:291-305. 2013
- Expert approaches to common bleeding and thrombotic problems, part II.. Seminars in Thrombosis and Hemostasis. 39:113-116. 2013
- Expert approaches to common bleeding and thrombotic problems-part I.. Seminars in Thrombosis and Hemostasis. 38:641-644. 2012
- Laboratory investigations for bleeding disorders.. Seminars in Thrombosis and Hemostasis. 38:742-752. 2012
- External quality assessment of platelet disorder investigations: results of international surveys on diagnostic tests for dense granule deficiency and platelet aggregometry interpretation.. Seminars in Thrombosis and Hemostasis. 38:622-631. 2012
- Global haemostasis and point of care testing. Haemophilia. 18:81-88. 2012
- Protein C assay performance: an analysis of North American specialized coagulation laboratory association proficiency testing results.. American Journal of Clinical Pathology. 137:909-915. 2012
- Approaches to investigating common bleeding disorders: an evaluation of North American coagulation laboratory practices.. American Journal of Hematology. 87 Suppl 1:S45-S50. 2012
- Simultaneous measurement of adenosine triphosphate release and aggregation potentiates human platelet aggregation responses for some subjects, including persons with Quebec platelet disorder.. Thrombosis and Haemostasis. 107:726-734. 2012
- Critical values in the coagulation laboratory: results of a survey of the North American Specialized Coagulation Laboratory Association.. American Journal of Clinical Pathology. 136:836-841. 2011
- A prospective cohort study of light transmission platelet aggregometry for bleeding disorders: is testing native platelet-rich plasma non-inferior to testing platelet count adjusted samples?. Thrombosis and Haemostasis. 106:675-682. 2011
- Platelet activation in the pathogenesis of obesity and vascular disease.. Thrombosis and Haemostasis. 106:567-568. 2011
- Diagnostic usefulness of a lumi-aggregometer adenosine triphosphate release assay for the assessment of platelet function disorders.. American Journal of Clinical Pathology. 136:350-358. 2011
- Quebec platelet disorder: update on pathogenesis, diagnosis, and treatment.. Seminars in Thrombosis and Hemostasis. 37:713-720. 2011
- Thrombocytopenic platelet disorders.. Seminars in Thrombosis and Hemostasis. 37:617-620. 2011
- Clinician investigator training in Canada: a review.. Clinical and Investigative Medicine. 34:E192. 2011
- Diagnostic evaluation of platelet function disorders.. Blood Reviews. 25:169-173. 2011
- Quebec platelet disorder.. Expert Review of Hematology. 4:137-141. 2011
- Development of North American consensus guidelines for medical laboratories that perform and interpret platelet function testing using light transmission aggregometry.. American Journal of Clinical Pathology. 134:955-963. 2010
- New developments in laboratory diagnosis and monitoring. Haemophilia. 16:61-66. 2010
- Mice with deleted multimerin 1 and alpha-synuclein genes have impaired platelet adhesion and impaired thrombus formation that is corrected by multimerin 1.. Thrombosis Research. 125:e177-e183. 2010
- Persons with Quebec platelet disorder have a tandem duplication of PLAU, the urokinase plasminogen activator gene.. Blood. 115:1264-1266. 2010
- Advances in understanding "high on-treatment platelet reactivity".. Thrombosis and Haemostasis. 102:799-800. 2009
- Results of a worldwide survey on the assessment of platelet function by light transmission aggregometry: a report from the platelet physiology subcommittee of the SSC of the ISTH.. Journal of Thrombosis and Haemostasis. 7:1029. 2009
- Results of an external proficiency testing exercise on platelet dense-granule deficiency testing by whole mount electron microscopy.. American Journal of Clinical Pathology. 131:671-675. 2009
- Diagnostic utility of light transmission platelet aggregometry: results from a prospective study of individuals referred for bleeding disorder assessments.. Journal of Thrombosis and Haemostasis. 7:676-684. 2009
- Platelet adhesion to multimerin 1 in vitro: influences of platelet membrane receptors, von Willebrand factor and shear.. Journal of Thrombosis and Haemostasis. 7:685-692. 2009
- Diagnostic assessment of platelet disorders: what are the challenges to standardization?. Seminars in Thrombosis and Hemostasis. 35:131-138. 2009
- Diagnostic evaluation of platelet disorders: the past, the present, and the future.. Seminars in Thrombosis and Hemostasis. 35:127-130. 2009
- Increased expression of urokinase plasminogen activator in Quebec platelet disorder is linked to megakaryocyte differentiation.. Blood. 113:1535-1542. 2009
- Quebec platelet disorder is linked to the urokinase plasminogen activator gene (PLAU) and increases expression of the linked allele in megakaryocytes.. Blood. 113:1543-1546. 2009
- Are laboratories following published recommendations for lupus anticoagulant testing? An international evaluation of practices.. Thrombosis and Haemostasis. 101:178-184. 2009
- Laboratory testing for fibrinogen abnormalities.. American Journal of Hematology. 83:928-931. 2008
- Multimerin 1 binds factor V and activated factor V with high affinity and inhibits thrombin generation.. Thrombosis and Haemostasis. 100:1058-1067. 2008
- An evaluation of methods for determining reference intervals for light transmission platelet aggregation tests on samples with normal or reduced platelet counts.. Thrombosis and Haemostasis. 100:134-145. 2008
- Evaluation of urokinase plasminogen activator in urine from individuals with Quebec platelet disorder.. Blood Coagulation and Fibrinolysis. 19:463-464. 2008
- Laboratory issues in bleeding disorders.. Haemophilia. 14 Suppl 3:93-103. 2008
- Multimerin 1.. Platelets. 19:83-95. 2008
- Quebec platelet disorder: features, pathogenesis and treatment.. Blood Coagulation and Fibrinolysis. 19:109-119. 2008
- An acquired factor V inhibitor associated with defective factor V function, storage and binding to multimerin 1.. Journal of Thrombosis and Haemostasis. 6:395-397. 2008
- Diagnostic approach to platelet function disorders.. Transfusion and Apheresis Science. 38:65-76. 2008
- Location of the multimerin 1 binding site in coagulation factor V: an update.. Thrombosis Research. 123:352-354. 2008
- Laboratory testing for heparin-induced thrombocytopenia is inconsistent in North America: a survey of North American specialized coagulation laboratories.. Thrombosis and Haemostasis. 98:1357-1361. 2007
- Platelet function testing: quality assurance.. Seminars in Thrombosis and Hemostasis. 33:273-282. 2007
- Congenital platelet disorders: overview of their mechanisms, diagnostic evaluation and treatment.. Haemophilia. 12 Suppl 3:128-136. 2006
- Platelet function analyzer (PFA)-100((R)) closure time in the evaluation of platelet disorders and platelet function: reply to a rebuttal. Journal of Thrombosis and Haemostasis. 4:1432-1432. 2006
- Platelet function analyzer (PFA)-100((R))closure time in the evaluation of platelet disorders and platelet function: reply to a rebuttal. Journal of Thrombosis and Haemostasis. 4:1433-1434. 2006
- Insights into abnormal hemostasis in the Quebec platelet disorder from analyses of clot lysis.. Journal of Thrombosis and Haemostasis. 4:1086-1094. 2006
- Platelet function analyzer (PFA)-100 closure time in the evaluation of platelet disorders and platelet function.. Journal of Thrombosis and Haemostasis. 4:312-319. 2006
- Analyses of cellular multimerin 1 receptors: in vitro evidence of binding mediated by alphaIIbbeta3 and alphavbeta3.. Thrombosis and Haemostasis. 94:1004-1011. 2005
- Endocytosis and storage of plasma factor V by human megakaryocytes.. Thrombosis and Haemostasis. 94:585-592. 2005
- Variability in clinical laboratory practice in testing for disorders of platelet function: results of two surveys of the North American Specialized Coagulation Laboratory Association.. Thrombosis and Haemostasis. 93:549-553. 2005
- Bleeding and thrombotic problems in a patient with alpha2 plasmin inhibitor deficiency.. Journal of Thrombosis and Haemostasis. 3:399-401. 2005
- Diagnosis and management of mild bleeding disorders.. Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program. 2005:423-428. 2005
- Prophylactic and perioperative replacement therapy for acquired factor XIII deficiency: reply to a rebuttal.. Journal of Thrombosis and Haemostasis. 3:187-188. 2005
- Identification of the MMRN1 binding region within the C2 domain of human factor V.. Journal of Biological Chemistry. 279:51466-51471. 2004
- Dissociation between the level of von Willebrand factor-cleaving protease activity and disease in a patient with congenital thrombotic thrombocytopenic purpura.. American Journal of Hematology. 77:387-390. 2004
- Human platelets contain forms of factor V in disulfide-linkage with multimerin.. Thrombosis and Haemostasis. 92:1349-1357. 2004
- Further complexities in diagnosing acquired thrombocytopenia: unexpected parallels between antibody-mediated delayed thrombocytopenia with abciximab and heparin induced thrombocytopenia.. Thrombosis and Haemostasis. 92:674-675. 2004
- Bleeding risks associated with inheritance of the Quebec platelet disorder.. Blood. 104:159-165. 2004
- Prospective screening of 205 patients with ITP, including diagnosis, serological markers, and the relationship between platelet counts, endogenous thrombopoietin, and circulating antithrombopoietin antibodies.. American Journal of Hematology. 76:205-213. 2004
- Prophylactic and perioperative replacement therapy for acquired factor XIII deficiency.. Journal of Thrombosis and Haemostasis. 2:1017-1019. 2004
- Extending knowledge on inherited platelet disorders associated with thrombocytopenia.. Thrombosis and Haemostasis. 90:770-771. 2003
- Studies of alpha-granule proteins in cultured human megakaryocytes.. Thrombosis and Haemostasis. 90:844-852. 2003
- Inherited platelet disorders.. Current Opinion in Hematology. 10:362-368. 2003
- Intracellular activation of the fibrinolytic cascade in the Quebec Platelet Disorder.. Thrombosis and Haemostasis. 90:293-298. 2003
- Decreased von Willebrand factor protease activity associated with thrombocytopenic disorders.. Blood. 98:1842-1846. 2001
- Platelets from patients with the Quebec platelet disorder contain and secrete abnormal amounts of urokinase-type plasminogen activator.. Blood. 98:257-265. 2001
- The storage defects in grey platelet syndrome and alphadelta-storage pool deficiency affect alpha-granule factor V and multimerin storage without altering their proteolytic processing.. British Journal of Haematology. 113:871-877. 2001
- Platelet factor V New York: a defect in factor V distinct from that in factor V Quebec resulting in impaired prothrombinase generation.. American Journal of Hematology. 66:130-139. 2001
- Morphological analysis of microparticle generation in heparin-induced thrombocytopenia.. Blood. 96:188-194. 2000
- Loss of factor VIII activity during storage in PVC containers due to adsorption.. Haemophilia. 6:89-92. 2000
- Platelet multimerin and its proteolytic processing.. Thrombosis and Haemostasis. 82:1779-1780. 1999
- Measurement of endogenous and exogenous alpha-granular platelet proteins in patients with immune and nonimmune thrombocytopenia.. British Journal of Haematology. 106:762-770. 1999
- Multimerin processing by cells with and without pathways for regulated protein secretion.. Blood. 94:1337-1347. 1999
- Serum-induced platelet procoagulant activity: an assay for the characterization of prothrombotic disorders.. Journal of Laboratory and Clinical Medicine Translational Research. 133:129-133. 1999
- Studies of multimerin in patients with von Willebrand disease and platelet von Willebrand factor deficiency.. British Journal of Haematology. 103:20-28. 1998
- ABH antigens on human platelets: expression on the glycosyl phosphatidylinositol-anchored protein CD109.. Journal of Laboratory and Clinical Medicine Translational Research. 132:142-148. 1998
- Studies of multimerin in human endothelial cells.. Blood. 91:1304-1317. 1998
- The pathogenesis of venous limb gangrene associated with heparin-induced thrombocytopenia.. Annals of Internal Medicine. 127:804-812. 1997
- Maternal immunization to Gov system alloantigens on human platelets.. Transfusion. 37:823-828. 1997
- Multimerin: a bench-to-bedside chronology of a unique platelet and endothelial cell protein--from discovery to function to abnormalities in disease.. Clinical and Investigative Medicine. 20:176-187. 1997
- Proteolytic degradation of high molecular weight kininogen in acute thrombotic thrombocytopenic purpura.. British Journal of Haematology. 97:762-767. 1997
- Fibrinogen degradation products in patients with the Quebec platelet disorder.. British Journal of Haematology. 97:497-503. 1997
- Failure of pulse high-dose dexamethasone in chronic idiopathic immune thrombocytopenia.. American Journal of Hematology. 54:267-270. 1997
- Studies of a second family with the Quebec platelet disorder: evidence that the degradation of the alpha-granule membrane and its soluble contents are not secondary to a defect in targeting proteins to alpha-granules.. Blood. 89:1243-1253. 1997
- Inherited disorders of platelet alpha-granules.. Platelets. 8:197-209. 1997
- A diagnostic test for heparin-induced thrombocytopenia: detection of platelet microparticles using flow cytometry.. British Journal of Haematology. 95:724-731. 1996
- The epitope specificity of heparin-induced thrombocytopenia.. British Journal of Haematology. 95:161-167. 1996
- Splenectomy done during hematologic remission to prevent relapse in patients with thrombotic thrombocytopenic purpura.. Annals of Internal Medicine. 125:294-296. 1996
- An autosomal dominant, qualitative platelet disorder associated with multimerin deficiency, abnormalities in platelet factor V, thrombospondin, von Willebrand factor, and fibrinogen and an epinephrine aggregation defect.. Blood. 87:4967-4978. 1996
- Isolation and characterization of cysteine proteinase in thrombotic thrombocytopenic purpura.. British Journal of Haematology. 93:421-426. 1996
- The prenatal identification of fetal compatibility in neonatal alloimmune thrombocytopenia using amniotic fluid and variable number of tandem repeat (VNTR) analysis.. British Journal of Haematology. 91:742-746. 1995
- Characterization and localization of the Gova/b alloantigens to the glycosylphosphatidylinositol-anchored protein CDw109 on human platelets.. Blood. 86:2807-2814. 1995
- Multimerin.. Current Opinion in Hematology. 2:339-344. 1995
- Factor V is complexed with multimerin in resting platelet lysates and colocalizes with multimerin in platelet alpha-granules.. Journal of Biological Chemistry. 270:19217-19224. 1995
- The cDNA sequence of human endothelial cell multimerin. A unique protein with RGDS, coiled-coil, and epidermal growth factor-like domains and a carboxyl terminus similar to the globular domain of complement C1q and collagens type VIII and X.. Journal of Biological Chemistry. 270:18246-18251. 1995
- Bacterial infection-associated improvement of platelet counts in two patients with chronic and unresponsive idiopathic thrombocytopenic purpura with normal platelet survival studies.. British Journal of Haematology. 90:332-335. 1995
- Multimerin: A Multimeric Protein Stored in Platelet Alpha-granules.. Platelets. 6:1-10. 1995
- Sera from patients with heparin-induced thrombocytopenia generate platelet-derived microparticles with procoagulant activity: an explanation for the thrombotic complications of heparin-induced thrombocytopenia.. Blood. 84:3691-3699. 1994
- Immunoglobulin G from patients with heparin-induced thrombocytopenia binds to a complex of heparin and platelet factor 4.. Blood. 83:3232-3239. 1994
- Treatment outcomes in patients with adult thrombotic thrombocytopenic purpura-hemolytic uremic syndrome.. Archives of Internal Medicine A.M.A. archives of internal medicine Archives of internal medicine (Chicago, Ill. : 1908). 154:982-987. 1994
- Heparin-induced thrombocytopenia and thrombosis: clinical and laboratory studies.. British Journal of Haematology. 84:322-328. 1993
- Multimerin is found in the alpha-granules of resting platelets and is synthesized by a megakaryocytic cell line.. Journal of Clinical Investigation. 91:2630-2639. 1993
- Investigation of human platelet alloantigens and glycoproteins using non-radioactive immunoprecipitation.. Journal of Immunological Methods. 158:77-85. 1993
- Calpain activity in patients with thrombotic thrombocytopenic purpura is associated with platelet microparticles.. Blood. 80:2246-2251. 1992
- Thrombotic thrombocytopenic purpura.. Blood Coagulation and Fibrinolysis. 3:655-659. 1992
- Determinants of donor platelet variability when testing for heparin-induced thrombocytopenia.. Journal of Laboratory and Clinical Medicine Translational Research. 120:371-379. 1992
- Thrombocytopenia caused by passive transfusion of anti-glycoprotein Ia/IIa alloantibody (anti-HPA-5b).. Blood. 79:2480-2484. 1992
- Investigation of the mechanisms of monoclonal antibody-induced platelet activation.. Blood. 78:1019-1026. 1991
- Multimerin: a series of large disulfide-linked multimeric proteins within platelets.. Blood. 77:2556-2560. 1991
- p-155, a multimeric platelet protein that is expressed on activated platelets.. Journal of Biological Chemistry. 266:7114-7120. 1991
- Gova/b alloantigen system on human platelets.. Blood. 75:2172-2176. 1990
- Sensitivity of rabbit platelet and aortic cyclooxygenase to inhibition by aspirin.. Prostaglandins Leukotrienes and Medicine. 12:235-244. 1983
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conference paper
- FALSE POSITIVE LUPUS ANTICOAGULANT TESTING WITH SEVERE FACTOR DEFICIENT PLASMA. Clinical and Laboratory Haematology International Journal of Laboratory Hematology. 24-24. 2017
- MODIFICATION AND VALIDATION OF A BARCODED CLAUSS FIBRINOGEN ASSAY FOR USE IN CORE LABORATORIES. Clinical and Laboratory Haematology International Journal of Laboratory Hematology. 77-77. 2017
- VARIABILITY IN ELECTRON MICROSCOPY RESULTS FOR SUBJECTS WITH MULTIPLE ASSESSMENTS FOR DENSE GRANULE DEFICIENCY. Clinical and Laboratory Haematology International Journal of Laboratory Hematology. 23-23. 2017
- Bleeding Risks Associated with Confirmed Platelet Dense Granule Deficiency and/or Impaired Aggregation Responses. Blood. 2016
- Genomic approaches to bleeding disorders.. Haemophilia. 42-45. 2016
- DUPLICATION OF THE PLAU LOCUS IN QUEBEC PLATELET DISORDER RESULTS IN A MEGAKARYOCYTE-SPECIFIC UP-REGULATION OF CANONICAL PLAU TRANSCRIPTS, WITH DYSREGULATION OF ADDITIONAL GENES IN MEGAKARYOCYTES. Clinical and Laboratory Haematology International Journal of Laboratory Hematology. 45-46. 2016
- HOW DO THEY PERFORM? VALIDATION AND ASSESSMENT OF PERFORMANCE OF 19 COAGULATION ANALYZERS ACROSS A REGIONAL LABORATORY PROGRAM.. Clinical and Laboratory Haematology International Journal of Laboratory Hematology. 73-74. 2016
- LABORATORY ADHERENCE TO ISTH GUIDELINES ON PLATELET AGGREGATION TESTING. INITIAL REVIEW OF RESULTS FROM AN INTERNATIONAL SURVEY.. Clinical and Laboratory Haematology International Journal of Laboratory Hematology. 74-75. 2016
- LABORATORY APPROACH TO PLATELET DISORDERS. Clinical and Laboratory Haematology International Journal of Laboratory Hematology. 45-45. 2016
- QUANTITATIVE D-DIMER AND PLATELET COUNT. LABORATORY TEST UTILIZATION IN HEPARIN INDUCED THROMBOCYTOPENIA POSITIVE PATIENTS.. Clinical and Laboratory Haematology International Journal of Laboratory Hematology. 73-73. 2016
- WHO IS RIGHT? VARIABILITY IN ANTI XA ACTIVITY LEVELS. ONE CENTER & RSQUO;S EXPERIENCE.. Clinical and Laboratory Haematology International Journal of Laboratory Hematology. 74-74. 2016
- Novel RUNX1 Mutation in a Family with an Uncharacterized Secretion Defect. Blood. 2015
- Effect of Quebec platelet disorder on leukocyte urokinase plasminogen activator (uPA) levels. Journal of Thrombosis and Haemostasis. 239-240. 2015
- CLINICAL UTILITY OF 1:1 ACTIVATED PARTIAL THROMBOPLASTIN TIME (APTT) MIXING STUDY USING A LUPUS INSENSITIVE REAGENT.. American Journal of Hematology. E23-E24. 2014
- EVALUATION OF AN AUTOMATED LATEX IMMUNOASSAY FOR VON WILLEBRAND FACTOR ANTIGEN ADAPTED FOR THE STA-R EVOLUTION. Clinical and Laboratory Haematology International Journal of Laboratory Hematology. 94-94. 2014
- MULTIMERIN1 BINDS TO A CONSENSUS SEQUENCE ON COLLAGEN THAT SUPPORTS PLATELET ADHESION. American Journal of Hematology. E15-E15. 2014
- UPDATE ON VON WILLEBRAND FACTOR TESTING: COMPARISON OF NEW AND OLD ACTIVITY ASSAYS FOR DIAGNOSING AND MONITORING VON WILLEBRAND DISEASE. Clinical and Laboratory Haematology International Journal of Laboratory Hematology. 23-23. 2014
- VARIABILITY IN FINDINGS FOR PLATELET DENSE GRANULE ADENOSINE TRIPHOSPHATE RELEASE AMONGST PATIENTS WITH MULTIPLE EVALUATIONS: IMPLICATIONS FOR DIAGNOSIS. American Journal of Hematology. E16-E17. 2014
- VWF A1A2A3 DOMAINS SUPPORT MMRN1 PLATELET ADHESIVE PROPERTIES. American Journal of Hematology. E14-E14. 2014
- Quebec Platelet Disorder Is Associated With Greater Than Expected Increases In Urokinase Plasminogen Activator In Granulocytes and Monocytes. Blood. 2013
- A REGIONAL QUALITY ASSURANCE PROGRAM FOR CORE COAGULATION LABORATORIES-5 YEARS LATER. Clinical and Laboratory Haematology International Journal of Laboratory Hematology. 14-14. 2013
- EVALUATION OF AN AUTOMATED ASSAY FOR VON WILLEBRAND FACTOR ACTIVITY ADAPTED FOR THE STA-R. Clinical and Laboratory Haematology International Journal of Laboratory Hematology. 65-66. 2013
- FACTOR XIII DIAGNOSTIC TESTING: A RETROSPECTIVE ANALYSIS OF ONE CENTER'S EXPERIENCE. Clinical and Laboratory Haematology International Journal of Laboratory Hematology. 73-74. 2013
- IMPROVING BLOOD DISORDER DIAGNOSIS: REFLECTIONS ON THE CHALLENGES. Clinical and Laboratory Haematology International Journal of Laboratory Hematology. 2-2. 2013
- LABORATORY TESTING FOR BLEEDING DISORDERS: STRATEGIC USES OF HIGH AND LOW YIELD TESTS. Clinical and Laboratory Haematology International Journal of Laboratory Hematology. 24-24. 2013
- Diagnostic usefulness of adenosine triphosphate release assays and aggregation tests with native or platelet-count-adjusted, platelet-rich plasma. Haemophilia. 99-100. 2012
- ORAL ABSTRACT: EXTERNAL PROFICIENCY TESTING ASSESSMENT - RESULTS OF SURVEYS ON DENSE GRANULE DEFICIENCY. Clinical and Laboratory Haematology International Journal of Laboratory Hematology. 41-42. 2012
- USEFULNESS OF SCREENING TESTS OF COAGULATION IN BLEEDING DISORDER INVESTIGATIONS - ANALYSIS OF A LARGE, PROSPECTIVE COHORT. Clinical and Laboratory Haematology International Journal of Laboratory Hematology. 164-164. 2012
- Are Clinical Laboratories Following Published Guidelines for the Interpretation of Light Transmission Aggregometry? Results from a Nascola Patterns-of-Practice Survey. American Journal of Hematology. S173-S173. 2012
- Characterization of the Binding Between the Polymeric Platelet Adhesive Proteins, Multimerin 1 and Von Willebrand Factor. Blood. 519-519. 2011
- Dysregulation of C10orf55 Expression in Megakaryocytic Cell Lineage From Quebec Platelet Disorder Individuals. Blood. 987-987. 2011
- Interaction of Multimerin 1 with Collagens: Role in Platelet Adhesion. Blood. 961-961. 2011
- A prospective cohort study of bleeding symptoms among persons referred to hematologists who are diagnosed with or excluded of having bleeding disorders. Journal of Thrombosis and Haemostasis. 687-688. 2011
- Bleeding risks associated with inherited platelet disorders: results from a prospective cohort study. Journal of Thrombosis and Haemostasis. 687-687. 2011
- Measurement of platelet adenosine triphosphate release unexpectedly normalizes aggregation findings in some subjects, including persons with Quebec platelet disorder. Journal of Thrombosis and Haemostasis. 742-742. 2011
- A review of experiences with external quality assessment challenges for several platelet function disorder assays offered by the North American specialized coagulation laboratory association. Haemophilia. 562-562. 2011
- Bleeding symptoms and risks in undefined bleeding disorders: results from a prospective study. Haemophilia. 562-562. 2011
- Dysregulation of PLAU expression in Quebec platelet disorder extends beyond megakaryocytic lineage, also affecting myeloid cell contents of urokinase plasminogen activator. Haemophilia. 556-556. 2011
- Standardization of platelet function testing in bleeding disorders. Haemophilia. 83-83. 2010
- Critical Values in the Coagulation Laboratory: Results of a Survey of the North American Specialized Coagulation Laboratory Association. Blood. 576-576. 2009
- Diagnostic Utility of Platelet Secretion Testing by ATP Release Assays: Results From a Prospective Study of Individuals Referred for Bleeding Disorder Assessments.. Blood. 537-538. 2009
- An international evaluation of clinical laboratory practices for Lupus anticoagulant testing. Haemophilia. 628-628. 2009
- Evaluation of a method to assess platelet function in individuals with thrombocytopenia. Haemophilia. 626-626. 2009
- Heterogeneity in platelet alpha-granule content assessed by evaluation of alpha-granule protein storage in Quebec platelet disorder. Haemophilia. 626-626. 2009
- Platelet adhesion to multimerin 1: influences of shear, platelet activation and platelet receptors. Haemophilia. 626-626. 2009
- AN APPROACH FOR THE DEVELOPMENT OF REFERENCE INTERVALS FOR PLATELET AGGREGATION TESTING. American Journal of Hematology. 942-942. 2008
- ARE CLINICAL LABORATORIES FOLLOWING ISTH RECOMMENDATIONS FOR LUPUS ANTICOAGULANT TESTING? RESULTS OF A 2(ND) NASCOLA SURVEY. American Journal of Hematology. 942-942. 2008
- EVALUATION OF PLATELET AGGREGATION RESPONSES IN SAMPLES WITH REDUCED PLATELET COUNTS. American Journal of Hematology. 943-943. 2008
- NASCOLA 1997-2007: LOOKING BACK AND FORWARD. American Journal of Hematology. 945-945. 2008
- PLATELET FUNCTIONAL DISORDERS AND TESTING. American Journal of Hematology. 946-946. 2008
- THE EFFECT OF DIFFERENT SAMPLE TYPES ON COAGULATION LABORATORY TESTS. American Journal of Hematology. 943-943. 2008
- THE NASCOLA/ECAT LUPUS ANTICOAGULANT (LA) AND ANTIPHOSPHOLIPID ANTIBODY (APL) TESTING PRACTICES QUESTIONNAIRE. American Journal of Hematology. 947-947. 2008
- C57BL/6JOlaHsd Mice with Tandem Deletion of the Multimerin 1and Alpha-Synuclein Genes Have Impaired Platelet Function in Vivo and in Vitro That Can Be Corrected by Multimerin 1. Blood. 1337-1337. 2008
- Quebec Platelet Disorder Is Caused by a Cis-Acting Mutation near the Plasminogen Activator Gene (PLAU) That Increases PLAU Transcription by Megakaryocytes. Blood. 1164-1164. 2008
- Evaluation of urokinase plasminogen activator in urine from individuals with Quebec platelet disorder. Haemophilia. 107-107. 2008
- Megakaryocytes from individuals with the Quebec platelet disorder show a maturation related defect in urokinase plasminogen activator expression. Haemophilia. 105-105. 2008
- Platelet function in the laboratory and its quality control. Haemophilia. 19-19. 2008
- Application of Levey-Jennings plots to the quality monitoring of platelet aggregation tests. Clinical and Laboratory Haematology International Journal of Laboratory Hematology. 91-91. 2008
- The challenge and importance of quality and standardization in the diagnostic assessment of platelet function. Clinical and Laboratory Haematology International Journal of Laboratory Hematology. 17-17. 2008
- Gender differences in bleeding problems and implications for the assessment of a bleeding disorder. Blood. 639A-639A. 2007
- Proteomics in the study of qualitative platelet defects: Validation of the approach in the gray platelet syndrome and Quebec Platelet Disorder. Blood. 43B-43B. 2007
- Phospholipid composition influences the binding of multimerin 1 and factor V/Va to the platelet membrane and modulates thrombin generation in plasma. FASEB Journal. A980-A980. 2007
- Effects of multimerin 1 on platelet and plasma FV as determined by calibrated automated thrombography.. Blood. 460A-460A. 2006
- Factor V binding to multimerin 1: Modulation by factor V activation and binding sites in the factor VC1 and C2 domains.. Blood. 61A-61A. 2006
- Phospholipid components of the activated platelet surface determine multimerin 1 and factor V/Va binding, and modulate thrombin generation in plasma.. Blood. 55B-55B. 2006
- Urokinase-type plasminogen activator production by cultured megakaryocytes and blood outgrowth enclothelial cells in the Quebec platelet disorder.. Blood. 300A-300A. 2006
- Insights into disturbed hemostasis in the Quebec platelet disorder using thromboelastography, blood clots formed at low shear, and PeriVsion studies of fibrinolysis.. Blood. 604A-604A. 2005
- Mechanisms of static and shear-induced platelet adhesion: Differences in the adhesion supported by MMRN1 comparisons with other beta 3 integrin ligands.. Blood. 746A-746A. 2005
- Pitfalls in interpreting platelet function tests in thrombocytopenic patients referred by a hematologist for diagnostic testing: Results from a single center prospective study.. Blood. 75B-75B. 2005
- Human platelets contain forms of factor V in disulfide-linkage with multimerin.. Blood. 534A-534A. 2004
- Identification of the multimerin binding region within the C2 domain of human factor V using constructs generated by alanine-scanning and site-directed mutagenesis.. Blood. 39A-39A. 2004
- Secretable human megakaryocyte factor v endocytosed from plasma in complex with multimerin: The origin of human megakaryocyte factor V.. Blood. 534A-534A. 2004
- The proadhesive properties of multimerin in supporting cellular adhesion: Evidence for RGD and non-RGD dependent adhesive mechanisms.. Blood. 65B-65B. 2004
- Bleeding symptomatology associated with inheritance of the Quebec platelet disorder.. Blood. 785A-785A. 2003
- Platelet-dependent dissolution of fibrin clots in the Quebec platelet disorder.. Blood. 545A-545A. 2003
- Probing HUVEC granule compartments with recombinant fluorescent platelet factor 4: Evidence that Weibel-Palade bodies are not a default storage compartment.. Blood. 533A-533A. 2003
- Variability of clinical laboratory practice in testing for disorders of platelet function: Results of a second NASCOLA survey.. Blood. 785A-785A. 2003
- A prospective study of clinical laboratory findings in patients referred by a hematologist for investigation of a suspected platelet disorder.. Blood. 690A-690A. 2002
- Dissociation of vWF-cleaving protease activity and platelet count in a patient with familial thrombotic thrombocytopenia purpura.. Blood. 685A-685A. 2002
- Evidence of intracellular activation of the fibrinolytic cascade in the Quebec Platelet Disorder.. Blood. 688A-688A. 2002
- Severe bleeding problems in patients with acquired delta-storage pool disorder (delta-SPD) due to myelodysplastic and myeloproliferative disorders.. Blood. 689A-690A. 2002
- Successful dose adjusted replacement therapy in acquired factor XIII deficiency.. Blood. 495A-495A. 2002
- Multimerin storage and processing by human megakaryocytes in culture.. Blood. 51B-51B. 2001
- Platelet plasminogen contributes to u-PA dependent proteolysis of platelet alpha-granule proteins. Implications for the mechanism of stored platelet protein degradation in the Quebec Platelet Disorder.. Blood. 260A-260A. 2001
- A prospective cross-sectional study to characterize selected autoimmune (AI) markers and report the incidence of antithrombopoietin antibodies (alpha TPO) in patients with immune thrombocytopenic purpura (ITP).. Blood. 250A-250A. 2000
- Decreased von Willebrand factor proteolytic activity associated with thrombocytopenic disorders.. Blood. 531A-531A. 2000
- Evaluation of platelet morphology and the subcellular distribution of PAIgG in patients with ITP and non-immune thrombocytopenia.. Blood. 249A-249A. 2000
- Expression of CD109 with alternate forms of membrane anchoring unique to platelets and megakaryocytic cell lines.. Blood. 55B-55B. 2000
- Identification of the fibrinolytic protease released by platelets in the Quebec platelet disorder.. Blood. 815A-815A. 2000
- In vitro time-dependent changes of surface PAIgG in ITP and non-immune thrombocytopenia.. Blood. 65B-65B. 2000
- Possible pathways of IgG trafficking in platelets.. Blood. 250A-250A. 2000
- The impact of idiopathic thrombocytopenic purpura in pregnancy.. Blood. 248A-248A. 2000
- Treatment of chronic refractory idiopathic thrombocytopenic purpura with cyclophosphamide and cyclosporine.. Blood. 253A-253A. 2000
- Evaluation of clot formation in AS-3 red cells diluted with Ringer's Lactate. Transfusion. 132S-132S. 2000
- Evaluation of clot formation in AS-3 red cells diluted with Ringer's lactate.. Blood. 461A-461A. 1999
- Morphological investigation of microparticle generation in heparin-induced throbocytopenia using confocal microscope and electron microscopy.. Blood. 16A-16A. 1999
- Platelets contain and secrete disulfide-linked polymers of coagulation factor V.. Blood. 229A-229A. 1999
- Proteolysis of human platelet FcRIIa during activation induced by heparin-induced thrombocytopenia (HIT) sera.. Blood. 442A-442A. 1999
- Comparison of the clinical utility of the platelet function analyzer (PFA-100 (TM)) and standard bleeding time in patients with hemostatic disorders.. Blood. 90B-90B. 1998
- Partial purification and characterization of serine protease activity in platelets and platelet releasates from patients with Quebec platelet disorder. Blood. 32A-32A. 1998
- Storage and processing of multimerin expressed in AtT 20 cells: Similarities and differences to platelet and endothelial cell-derived multimerin. Blood. 348A-348A. 1998
- The study of PAIgG distribution in patients with immune and nonimmune thrombocytopenia using confocal microscopy.. Blood. 176A-177A. 1998
- A prospective study of antigen capture assays for the investigation of idiopathic thrombocytopenic purpura (ITP).. Blood. 2037-2037. 1997
- Characterization of recombinant multimerin.. Blood. 2072-2072. 1997
- Measurement of endogenous and exogenous alpha granular platelet proteins in patients with immune and nonimmune thrombocytopenia.. Blood. 2040-2040. 1997
- Persistence of anti-glycoprotein IIb/IIIa antibodies in patients in complete remission from idiopathic thrombocytopenic purpura (ITP).. Blood. 2038-2038. 1997
- Sequestration of the Gov alloantigens into low density high molecular weight membrane fractions isolated from human platelets.. Blood. 3029-3029. 1997
- Studies of multimerin and platelet alpha-granular proteins in platelet low type 1 and type 3 von Willebrand disease.. Blood. 2659-2659. 1997
- alpha-granular protein degradation in the Quebec platelet disorder is associated with abnormal secretable platelet serine protease activity.. Blood. 1149-1149. 1997
- Investigation of multimerin in patients with ''platelet low'' type 1 von Willebrand disease. Thrombosis and Haemostasis. P2677-P2677. 1997
- Ultrastructural localization of multimerin in human endothelial cells. Thrombosis and Haemostasis. PS567-PS567. 1997
- ABH antigens are expressed on the GPI-anchored protein, CDw109, on human platelets.. Blood. 1270-1270. 1996
- Evaluation of a screening test for the Quebec qualitative platelet. Blood. 1273-1273. 1996
- Investigations of endothelial multimerin: Sorting to distinct secretory granules and extracellular matrix structures.. Blood. 2039-2039. 1996
- Maternal alloimmunization to the Gov(a)/Gov(b) antigens on human platelets.. Blood. 1271-1271. 1996
- Measurement of platelet procoagulant activity in heparin induced thrombocytopenia.. Blood. 3011-3011. 1996
- The degradation of the alpha-granule membrane and its soluble contents in the Quebec, qualitative platelet disorder is not secondary to a defect in targeting proteins to alpha-granules.. Blood. 1859-1859. 1996
- The loss of factor VIII activity during storage in PVC containers is due to protein adsorption and not proteolytic degradation.. Blood. 2111-2111. 1996
- Activated protein C resistance is not associated with postoperative deep vein thrombosis in patients undergoing hip or knee surgery.. Blood. 2450-2450. 1995
- Isolation and characterization of cysteine protease in thrombotic thrombocytopenic purpura.. Blood. 1134-1134. 1995
- Lightning strikes twice: Glanzmann's thrombasthenia in two half-sisters.. Blood. 3576-3576. 1995
- Multimerin deficiency in a second Quebec family.. Blood. 2186-2186. 1995
- Splenectomy reduces the frequency of relapse in patients with chronic relapsing TTP.. Blood. 343-343. 1995
- VENOUS LIMB GANGRENE COMPLICATING HEPARIN-INDUCED THROMBOCYTOPENIA - IMPLICATIONS FOR TRANSFUSION MEDICINE. Transfusion. S97-S97. 1995
- IDENTIFICATION OF AN AUTOSOMAL-DOMINANT BLEEDING DISORDER WITH A COMBINED DEFICIENCY OF PLATELET MULTIMERIN AND PLATELET FACTOR-V. Thrombosis and Haemostasis. 1190-1190. 1995
- THE CDNA SEQUENCE OF HUMAN ENDOTHELIAL-CELL MULTIMERIN - A NOVEL PROTEIN WITH RGDS, COILED-COIL, AND EGF DOMAINS, AND A CARBOXYL-TERMINUS SIMILAR TO THE GLOBULAR DOMAINS OF COMPLEMENT C1Q. Thrombosis and Haemostasis. 1054-1054. 1995
- THE EFFECT OF LOW-MOLECULAR-WEIGHT HEPARIN ON LA TESTING. Thrombosis and Haemostasis. 1271-1271. 1995
- DETECTION OF PLATELET-ASSOCIATED AUTOANTIBODIES TO THE GP-IIB/IIIA COMPLEX BY DIRECT RADIOIMMUNO-PRECIPITATION - A SPECIFIC TEST FOR IDIOPATHIC THROMBOCYTOPENIC PURPURA. Blood. A185-A185. 1994
- EVALUATION OF THE FC RECEPTOR IIA GENOTYPE FREQUENCIES AMONG PATIENTS WITH HEPARIN-INDUCED THROMBOCYTOPENIA. Blood. A661-A661. 1994
- FACTOR-V IS COMPLEXED WITH MULTIMERIN IN RESTING PLATELET LYSATES AND COLOCALIZES WITH MULTIMERIN WITHIN PLATELET ALPHA-GRANULES. Blood. A387-A387. 1994
- HETEROGENEITY OF THE MEMBRANE ANCHOR FOR GP175 EXPRESSING THE GOV ALLOANTIGEN SYSTEM. Blood. A472-A472. 1994
- IDENTIFICATION OF AN AUTOSOMAL-DOMINANT BLEEDING DISORDER THAT IS ASSOCIATED WITH A DEFICIENCY OF PLATELET MULTIMERIN AND A DEFECT IN PLATELET FACTOR-V. Blood. A110-A110. 1994
- THE CDNA SEQUENCE OF HUMAN ENDOTHELIAL-CELL MULTIMERIN - A NOVEL PROTEIN WITH RGDS, COILED-COIL, AND EGF DOMAINS, AND A CARBOXYL-TERMINUS SIMILAR TO THE GLOBULAR DOMAINS OF THE TRIMERIC PROTEINS C1Q AND COLLAGENS TYPE-VIII AND TYPE-X. Blood. A243-A243. 1994
- THE DEVELOPMENT AND EVALUATION OF A NOVEL TEST FOR HEPARIN-INDUCED THROMBOCYTOPENIA. Blood. A188-A188. 1994
- THE ROLE OF PLATELET ALLOANTIGEN GENOTYPING AND VNTR ANALYSIS USING DNA-DERIVED FROM AMNIOTIC-FLUID IN THE MANAGEMENT OF NEONATAL ALLOIMMUNE THROMBOCYTOPENIA. Blood. A527-A527. 1994
- BIOCHEMICAL-CHARACTERIZATION OF THE GOV ALLOANTIGEN ON HUMAN PLATELETS AND CELL-LINES. Blood. A269-A269. 1993
- CHARACTERIZATION OF MULTIMERIN EXPRESSION ON PLATELETS ACTIVATED IN-VITRO AND IN-VIVO. Blood. A158-A158. 1993
- CIRCULATING PLATELET-DERIVED MICROPARTICLES IN PATIENTS WITH HEPARIN-INDUCED THROMBOCYTOPENIA. Blood. A335-A335. 1993
- IGG FROM PATIENTS WITH HEPARIN-INDUCED THROMBOCYTOPENIA (HIT) BINDS TO A PF4/HEPARIN COMPLEX AND NOT TO HEPARIN ALONE. Blood. A335-A335. 1993
- PLATELET-DERIVED MICROPARTICLES ARE FOUND IN-VIVO IN PATIENTS WITH HEPARIN-INDUCED THROMBOCYTOPENIA (HIT). Thrombosis and Haemostasis. 912-912. 1993
- MULTIMERIN IS CONTAINED WITHIN THE GAMMA-GRANULES OF RESTING PLATELETS AND REDISTRIBUTES TO THE SURFACE-CONNECTED CANNALICULAR SYSTEM AND PLASMA-MEMBRANE FOLLOWING ACTIVATION. Clinical Research. A171-A171. 1992