An Autosomal Dominant, Qualitative Platelet Disorder Associated With Multimerin Deficiency, Abnormalities in Platelet Factor V, Thrombospondin, von Willebrand Factor, and Fibrinogen and an Epinephrine Aggregation Defect

Multimerin is a massive soluble, multimeric protein found in platelets and endothelial cells. Recent studies identified multimerin as a specific coagulation factor V binding protein, complexed with platelet, but not plasma, factor V. These findings led us to investigate individuals with inherited factor V deficiencies for possible multimerin abnormalities. Platelet proteins were evaluated using immunoassays, sodium dodecyl …