Journal article
Intracellular activation of the fibrinolytic cascade in the Quebec Platelet Disorder
Abstract
The Quebec Platelet Disorder (QPD) is an unusual bleeding disorder associated with increased platelet stores of urokinase-type plasminogen activator (u-PA) and proteolysis of platelet alpha-granule proteins. The increased u-PA and proteolyzed plasminogen in QPD platelets led us to investigate possible contributions of intracellular plasmin generation to QPD alpha-granule proteolysis. ELISA indicated there were normal amounts of plasminogen and …
Authors
Sheth PM; Kahr WHA; Haq MA; Veljkovic DK; Rivard GE; Hayward CPM
Journal
Thrombosis and Haemostasis, Vol. 90, No. 02, pp. 293–298
Publisher
Thieme
Publication Date
2003
DOI
10.1160/th02-12-0323
ISSN
0340-6245