Xenograft Model Antitumor Assays Concept

subject area of

• Cynara scolymus affects malignant pleural mesothelioma by promoting apoptosis and restraining invasion  Journal Articles
• fac‐[TcO₃(tacn)]⁺: A Versatile Precursor for the Labelling of Pharmacophores, Amino Acids and Carbohydrates through a New Ligand‐Centred Labelling Strategy  Journal Articles
• A New Strategy To Improve the Metabolic Stability of Lactone: Discovery of (20S,21S)-21-Fluorocamptothecins as Novel, Hydrolytically Stable Topoisomerase I Inhibitors  Journal Articles
• A Patient-Derived Xenograft Model of Glioblastoma  Journal Articles
• A STAT3-NFkB/DDIT3/CEBPβ axis modulates ALDH1A3 expression in chemoresistant cell subpopulations  Journal Articles
• A genome-wide in vivo CRISPR activation screen identifies BACE1 as a therapeutic vulnerability of lung cancer brain metastasis.  Journal Articles
• A kinome drug screen identifies multi-TKI synergies and ERBB2 signaling as a therapeutic vulnerability in MYC/TYR subgroup atypical teratoid rhabdoid tumors  Journal Articles
• A let-7 MicroRNA-sensitive Vesicular Stomatitis Virus Demonstrates Tumor-specific Replication  Journal Articles
• A role of SIPL1/SHARPIN in promoting resistance to hormone therapy in breast cancer  Journal Articles
• Adjuvant oncolytic virotherapy for personalized anti-cancer vaccination  Journal Articles
• Amplification of MUC1 in prostate cancer metastasis and CRPC development  Journal Articles
• An In Vivo Model of Recurrent Glioblastoma.  Chapters
• An effective kinase inhibition strategy for metastatic recurrent childhood medulloblastoma  Journal Articles
• Attenuation of the Glucocorticoid Response during Ad5IL-12 Adenovirus Vector Treatment Enhances Natural Killer Cell–Mediated Killing of MHC Class I–Negative LNCaP Prostate Tumors  Journal Articles
• Autoantibodies against the cell surface–associated chaperone GRP78 stimulate tumor growth via tissue factor  Journal Articles
• BMI1 is a therapeutic target in recurrent medulloblastoma  Conferences
• Bioluminescent Imaging of Patient-Derived Brain Tumors in Live Mice.  Chapters
• Bmi1 regulates human glioblastoma stem cells through activation of differential gene networks in CD133+ brain tumor initiating cells  Journal Articles
• Characterization of Mutational Status, Spheroid Formation, and Drug Response of a New Genomically-Stable Human Ovarian Clear Cell Carcinoma Cell Line, 105C  Journal Articles
• Characterization of sphere-propagating cells with stem-like properties from DU145 prostate cancer cells  Journal Articles
• Chemotherapeutic agents attenuate CXCL12-mediated migration of colon cancer cells by selecting for CXCR4-negative cells and increasing peptidase CD26  Journal Articles
• Chimeric Antigen Receptor T Cell Production for Brain Cancers.  Chapters
• Chronic Inhibition of STAT3/STAT5 in Treatment-Resistant Human Breast Cancer Cell Subtypes: Convergence on the ROS/SUMO Pathway and Its Effects on xCT Expression and System xc- Activity  Journal Articles
• Chronic modulation of AMP-Kinase, Akt and mTOR pathways by ionizing radiation in human lung cancer xenografts  Journal Articles
• Combined CXC chemokine and interleukin-12 gene transfer enhances antitumor immunity  Journal Articles
• Combined Radionuclide Therapy and Immunotherapy for Treatment of Triple Negative Breast Cancer  Journal Articles
• Combining Vascular Normalization with an Oncolytic Virus Enhances Immunotherapy in a Preclinical Model of Advanced-Stage Ovarian Cancer  Journal Articles
• Compound Kushen Injection suppresses human breast cancer stem-like cells by down-regulating the canonical Wnt/β-catenin pathway  Journal Articles
• Cotargeting Ephrin Receptor Tyrosine Kinases A2 and A3 in Cancer Stem Cells Reduces Growth of Recurrent Glioblastoma  Journal Articles
• Customized Viral Immunotherapy for HPV-Associated Cancer  Journal Articles
• Deciphering the Immunomodulatory Capacity of Oncolytic Vaccinia Virus to Enhance the Immune Response to Breast Cancer  Journal Articles
• Disease stage-specific role of the mitochondrial pyruvate carrier suppresses differentiation in temozolomide and radiation-treated glioblastoma.  Journal Articles
• Distribution of the anticancer drugs doxorubicin, mitoxantrone and topotecan in tumors and normal tissues  Journal Articles
• Doxycycline decreases tumor burden in a bone metastasis model of human breast cancer.  Journal Articles
• Dynamic Contrast-Enhanced Magnetic Resonance Imaging of Vascular Changes Induced by Sunitinib in Papillary Renal Cell Carcinoma Xenograft Tumors  Journal Articles
• Effect of zoledronic acid on the doxycycline-induced decrease in tumour burden in a bone metastasis model of human breast cancer  Journal Articles
• Epigenomic alterations define lethal CIMP-positive ependymomas of infancy  Journal Articles
• Establishment in Severe Combined Immunodeficiency Mice of Subrenal Capsule Xenografts and Transplantable Tumor Lines from a Variety of Primary Human Lung Cancers: Potential Models for Studying Tumor Progression–Related Changes  Journal Articles
• Estrogen Receptor β Is a Novel Target in Acute Myeloid Leukemia  Journal Articles
• Expanded CD56superbrightCD16+ NK Cells from Ovarian Cancer Patients Are Cytotoxic against Autologous Tumor in a Patient-Derived Xenograft Murine Model  Journal Articles
• Expressing human interleukin-15 from oncolytic vesicular stomatitis virus improves survival in a murine metastatic colon adenocarcinoma model through the enhancement of anti-tumor immunity  Journal Articles
• Fusion of TTYH1 with the C19MC microRNA cluster drives expression of a brain-specific DNMT3B isoform in the embryonal brain tumor ETMR  Journal Articles
• Gene Transfer of Matrix Metalloproteinase-9 Induces Tumor Regression of Breast CancerIn vivo  Journal Articles
• Grain‐sized moxibustion promotes NK cell antitumour immunity by inhibiting adrenergic signalling in non–small cell lung cancer  Journal Articles
• HER3 targeting of adenovirus by fiber modification increases infection of breast cancer cells in vitro, but not following intratumoral injection in mice  Journal Articles
• Human pluripotent stem cells identify molecular targets of trisomy 12 in chronic lymphocytic leukemia patients  Journal Articles
• Identification of Chemotherapy-Induced Leukemic-Regenerating Cells Reveals a Transient Vulnerability of Human AML Recurrence  Journal Articles
• Immuno-gene therapy of established prostate tumors using chimeric receptor-redirected human lymphocytes.  Journal Articles
• Inhibiting STAT3 in a murine model of human breast cancer-induced bone pain delays the onset of nociception  Journal Articles
• Inhibition of breast cancer-cell glutamate release with sulfasalazine limits cancer-induced bone pain  Journal Articles
• Inhibition of carbonic anhydrase IX (CA9) sensitizes renal cell carcinoma to ionizing radiation  Journal Articles
• Inhibition of the colony-stimulating-factor-1 receptor affects the resistance of lung cancer cells to cisplatin  Journal Articles
• Intratumoral Delivery of Chimeric Antigen Receptor T Cells Targeting CD133 Effectively Treats Brain Metastases  Journal Articles
• Metformin elicits anticancer effects through the sequential modulation of DICER and c-MYC  Journal Articles
• Metformin inhibits growth and enhances radiation response of non-small cell lung cancer (NSCLC) through ATM and AMPK  Journal Articles
• Micro-chemical synthesis of molecular probes on an electronic microfluidic device  Journal Articles
• Multistage nanoparticle delivery system for deep penetration into tumor tissue  Journal Articles
• ORFV: A Novel Oncolytic and Immune Stimulating Parapoxvirus Therapeutic  Journal Articles
• Oncolytic Maraba virus armed with tumor antigen boosts vaccine priming and reveals diverse therapeutic response patterns when combined with checkpoint blockade in ovarian cancer  Journal Articles
• Overexpression of MUC1 and Genomic Alterations in Its Network Associate with Prostate Cancer Progression  Journal Articles
• PI3K Inhibitors Curtail MYC-Dependent Mutant p53 Gain-of-Function in Head and Neck Squamous Cell Carcinoma  Journal Articles
• Pancratistatin Selectively Targets Cancer Cell Mitochondria and Reduces Growth of Human Colon Tumor Xenografts  Journal Articles
• Pancratistatin induces apoptosis and autophagy in metastatic prostate cancer cells  Journal Articles
• Personalizing the Treatment of Pediatric Medulloblastoma: Polo-like Kinase 1 as a Molecular Target in High-Risk Children  Journal Articles
• Photodynamic Therapy of Established Prostatic Adenocarcinoma with TOOKAD: A Biphasic Apparent Diffusion Coefficient Change as Potential Early MRI Response Marker  Journal Articles
• Preclinical Testing of CAR T Cells in a Patient-Derived Xenograft Model of Glioblastoma  Journal Articles
• Preclinical development of peptide vaccination combined with oncolytic MG1-E6E7 for HPV-associated cancer  Journal Articles
• Preclinical evaluation of a new liposomal formulation of cisplatin, lipoplatin, to treat cisplatin-resistant cervical cancer  Journal Articles
• Preliminary evaluation of alpha-emitting radioembolization in animal models of hepatocellular carcinoma  Journal Articles
• Preparation and Evaluation of Radiolabeled Antibody Recruiting Small Molecules That Target Prostate-Specific Membrane Antigen for Combined Radiotherapy and Immunotherapy  Journal Articles
• Programmable insect cell carriers for systemic delivery of integrated cancer biotherapy  Journal Articles
• Pyrimethamine as a Potent and Selective Inhibitor of Acute Myeloid Leukemia Identified by High-throughput Drug Screening  Journal Articles
• Pyrvinium Targets CD133 in Human Glioblastoma Brain Tumor–Initiating Cells  Journal Articles
• Reactivation of mutant p53 by a dietary-related compound phenethyl isothiocyanate inhibits tumor growth  Journal Articles
• Regional Localization within the Bone Marrow Influences the Functional Capacity of Human HSCs  Journal Articles
• Repurposed AT9283 triggers anti-tumoral effects by targeting MKK3 oncogenic functions in Colorectal Cancer.  Journal Articles
• Salicylate enhances the response of prostate cancer to radiotherapy  Journal Articles
• Serotonergic system antagonists target breast tumor initiating cells and synergize with chemotherapy to shrink human breast tumor xenografts  Journal Articles
• Stem cell gene expression programs influence clinical outcome in human leukemia  Journal Articles
• Sulfasalazine‐induced cystine starvation: Potential use for prostate cancer therapy  Journal Articles
• Synthesis, Radiolabeling, and In Vivo Imaging of PEGylated High-Generation Polyester Dendrimers  Journal Articles
• TAp73 Modifies Metabolism and Positively Regulates Growth of Cancer Stem–Like Cells in a Redox-Sensitive Manner  Journal Articles
• TGFβ Programs Central Memory Differentiation inEx Vivo–Stimulated Human T Cells  Journal Articles
• TRF2 positively regulates SULF2 expression increasing VEGF-A release and activity in tumor microenvironment  Journal Articles
• Targeting axonal guidance dependencies in glioblastoma with ROBO1 CAR T cells  Journal Articles
• Targeting prostate cancer with HTI‐286, a synthetic analog of the marine sponge product hemiasterlin  Journal Articles
• The Antiarrhythmic Drug, Dronedarone, Demonstrates Cytotoxic Effects in Breast Cancer Independent of Thyroid Hormone Receptor Alpha 1 (THRα1) Antagonism  Journal Articles
• The Thrombospondin-1 Mimetic ABT-510 Increases the Uptake and Effectiveness of Cisplatin and Paclitaxel in a Mouse Model of Epithelial Ovarian Cancer  Journal Articles
• The chimeric TAC receptor co-opts the T cell receptor yielding robust anti-tumor activity without toxicity  Journal Articles
• The oncolytic adenovirus AdΔΔ enhances selective cancer cell killing in combination with DNA-damaging drugs in pancreatic cancer models  Journal Articles
• Therapeutic targeting of ependymoma as informed by oncogenic enhancer profiling  Journal Articles
• Transcriptional activation of the miR-17-92 cluster is involved in the growth-promoting effects of MYB in human Ph-positive leukemia cells  Journal Articles
• USP22 mediates the multidrug resistance of hepatocellular carcinoma via the SIRT1/AKT/MRP1 signaling pathway  Journal Articles
• Ultrasound Imaging of Apoptosis: Spectroscopic Detection of DNA-Damage Effects In Vivo  Journal Articles
• Upregulation of FAM84B during prostate cancer progression  Journal Articles
• WISH-PC2: a unique xenograft model of human prostatic small cell carcinoma.  Journal Articles
• hMENA is a key regulator in endothelin-1/β-arrestin1–induced invadopodial function and metastatic process  Journal Articles
• miR-30a inhibits endothelin A receptor and chemoresistance in ovarian carcinoma  Journal Articles
• β-arrestin1/YAP/mutant p53 complexes orchestrate the endothelin A receptor signaling in high-grade serous ovarian cancer  Journal Articles