Journal article
Dynamic Contrast-Enhanced Magnetic Resonance Imaging of Vascular Changes Induced by Sunitinib in Papillary Renal Cell Carcinoma Xenograft Tumors
Abstract
To investigate further the antiangiogenic potential of sunitinib for renal cell carcinoma (RCC) treatment, its effects on tumor vasculature were monitored by dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) using an orthotopic KCI-18 model of human RCC xenografts in nude mice. Tumor-bearing mice were treated with various doses of sunitinib, and vascular changes were assessed by DCE-MRI and histologic studies. Sunitinib induced …
Authors
Hillman GG; Singh-Gupta V; Zhang H; Al-Bashir AK; Katkuri Y; Li M; Yunker CK; Patel AD; Abrams J; Haacke EM
Journal
Neoplasia, Vol. 11, No. 9, pp. 910–920
Publisher
Elsevier
Publication Date
9 2009
DOI
10.1593/neo.09618
ISSN
1522-8002
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AnimalsAntineoplastic AgentsCapillary PermeabilityCarcinoma, Renal CellContrast MediaFemaleGadolinium DTPAHumansHypoxiaImmunoprecipitationIndolesKidney NeoplasmsMagnetic Resonance ImagingMiceMice, Inbred BALB CMice, NudeNeovascularization, PathologicPyrrolesReceptors, Platelet-Derived Growth FactorSunitinibTumor Cells, CulturedVascular Endothelial Growth Factor Receptor-2Xenograft Model Antitumor Assays