Journal article
A STAT3-NFkB/DDIT3/CEBPβ axis modulates ALDH1A3 expression in chemoresistant cell subpopulations
Abstract
Here we studied the relevance and modulation of aldehyde dehydrogenase (ALDH) expression in malignant pleural mesothelioma (MPM) chemoresistant cell subpopulations (ALDH(bright) cells), which survive pemetrexed + cisplatin treatment in vitro and in vivo. Expression of the ALDH1A3 isoform was invariably enriched in purified ALDH(bright) cells from multiple MPM cell lines and accounted for the enzymatic activity of those cells. RNAi mediated …
Authors
Canino C; Luo Y; Marcato P; Blandino G; Pass HI; Cioce M
Journal
Oncotarget, Vol. 6, No. 14, pp. 12637–12653
Publisher
Impact Journals
Publication Date
May 20, 2015
DOI
10.18632/oncotarget.3703
ISSN
1949-2553
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Aldehyde OxidoreductasesAnimalsBlotting, WesternCCAAT-Enhancer-Binding Protein-betaCell Line, TumorCell SeparationDrug Resistance, NeoplasmGene Expression Regulation, NeoplasticHumansImmunoprecipitationMesotheliomaMiceMicroscopy, FluorescenceNF-kappa BPleural NeoplasmsRNA, Small InterferingSTAT3 Transcription FactorSignal TransductionTranscription Factor CHOPTransfectionXenograft Model Antitumor Assays