Journal article
Targeting axonal guidance dependencies in glioblastoma with ROBO1 CAR T cells
Abstract
Resistance to genotoxic therapies and tumor recurrence are hallmarks of glioblastoma (GBM), an aggressive brain tumor. In this study, we investigated functional drivers of post-treatment recurrent GBM through integrative genomic analyses, genome-wide genetic perturbation screens in patient-derived GBM models and independent lines of validation. Specific genetic dependencies were found consistent across recurrent tumor models, accompanied by …
Authors
Chokshi CR; Shaikh MV; Brakel B; Rossotti MA; Tieu D; Maich W; Anand A; Chafe SC; Zhai K; Suk Y
Journal
Nature Medicine, Vol. 30, No. 10, pp. 2936–2946
Publisher
Springer Nature
Publication Date
October 2024
DOI
10.1038/s41591-024-03138-9
ISSN
1078-8956