Journal article
TRF2 positively regulates SULF2 expression increasing VEGF-A release and activity in tumor microenvironment
Abstract
The telomeric protein TRF2 is overexpressed in several human malignancies and contributes to tumorigenesis even though the molecular mechanism is not completely understood. By using a high-throughput approach based on the multiplexed Luminex X-MAP technology, we demonstrated that TRF2 dramatically affects VEGF-A level in the secretome of cancer cells, promoting endothelial cell-differentiation and angiogenesis. The pro-angiogenic effect of TRF2 …
Authors
Zizza P; Dinami R; Porru M; Cingolani C; Salvati E; Rizzo A; D’Angelo C; Petti E; Amoreo CA; Mottolese M
Journal
Nucleic Acids Research, Vol. 47, No. 7, pp. 3365–3382
Publisher
Oxford University Press (OUP)
Publication Date
April 23, 2019
DOI
10.1093/nar/gkz041
ISSN
0305-1048
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AnimalsCell Line, TumorColonic NeoplasmsHeparan Sulfate ProteoglycansHeparinHumansMaleMiceMice, NudeNeoplasm MetastasisNeovascularization, PathologicSulfatasesSulfotransferasesTelomeric Repeat Binding Protein 2Tumor MicroenvironmentVascular Endothelial Growth Factor AXenograft Model Antitumor Assays