Journal article
A role of SIPL1/SHARPIN in promoting resistance to hormone therapy in breast cancer
Abstract
SIPL1 inhibits PTEN function and stimulates NF-κB signaling; both processes contribute to resistance to hormone therapy in estrogen receptor positive breast cancer (ER+ BC). However, whether SIPL1 promotes tamoxifen resistance in BC remains unclear. We report here that SIPL1 enhances tamoxifen resistance in ER+ BC. Overexpression of SIPL1 in MCF7 and TD47 cells conferred tamoxifen resistance. In MCF7 cell-derived tamoxifen resistant (TAM-R) …
Authors
Ojo D; Wu Y; Bane A; Tang D
Journal
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Vol. 1864, No. 3, pp. 735–745
Publisher
Elsevier
Publication Date
March 2018
DOI
10.1016/j.bbadis.2017.12.018
ISSN
0925-4439