Bioluminescent Imaging of Patient-Derived Brain Tumors in Live Mice. Chapters

abstract

• Patient-derived tumor xenograft (PDX) models are crucial for understanding brain tumor progression and for pre-clinical evaluation of therapeutic interventions. Luciferase-based bioluminescence imaging offers a non-invasive approach to visualizing and quantifying tumor development across multiple time points. This chapter presents a methodology for employing the IVIS® (in vivo imaging) system to analyze tumor dynamics in luciferase expressing PDX brain tumor models.

authors

• McKenna, Dillon
• Venugopal, Chitra
• Singh, Sheila

status

• published 

publication date

• 2025

has subject area

• 0399 Other Chemical Sciences (FoR)
• 0601 Biochemistry and Cell Biology (FoR)
• Animals (MeSH)
• Brain Neoplasms (MeSH)
• Developmental Biology (Science Metrix)
• Disease Models, Animal (MeSH)
• Genes, Reporter (MeSH)
• Humans (MeSH)
• Luciferases (MeSH)
• Luminescent Measurements (MeSH)
• Mice (MeSH)
• Xenograft Model Antitumor Assays (MeSH)

published in

• Methods in molecular biology (Clifton, N.J.)  Journal

keywords

• Animals
• Bioluminescence
• Brain Neoplasms
• Brain tumor
• Disease Models, Animal
• Genes, Reporter
• Humans
• IVIS® Spectrum In Vivo Imaging System
• Luciferases
• Luminescent Measurements
• Mice
• Patient derived xenograft
• Quantification
• Tumor progression
• Xenograft Model Antitumor Assays

Digital Object Identifier (DOI)

• 10.1007/978-1-0716-4654-0_22

start page

• 287

end page

• 300

volume

• 2944