Journal article
fac‐[TcO3(tacn)]+: A Versatile Precursor for the Labelling of Pharmacophores, Amino Acids and Carbohydrates through a New Ligand‐Centred Labelling Strategy
Abstract
Herein, we report a protocol for the synthesis of [(99m)TcO(3)(tacn)](+) ([1](+)) (tacn = 1,4,7-triazacyclononane) that is suitable for clinical translation. Bioconjugates containing pharmacophores ([TcO(NO(2)-Imi)(tacn)](+); [3](+)), artificial amino acids ([TcO(Fmoc-allyl-His)(tacn)](+); [5](+)), and glucose derivatives ([TcO(allyl-tetraacetylglucose)(tacn)](+); [7](+)) were synthesized by cycloaddition strategies and fully characterized …
Authors
Braband H; Tooyama Y; Fox T; Simms R; Forbes J; Valliant JF; Alberto R
Journal
Chemistry - A European Journal, Vol. 17, No. 46, pp. 12967–12974
Publisher
Wiley
Publication Date
November 11, 2011
DOI
10.1002/chem.201101275
ISSN
0947-6539