Metformin Concept

subject area of

• A 42-year-old man with elevated ferritin  Journal Articles
• A randomised placebo-controlled trial of the effectiveness of early metformin in addition to usual care in the reduction of gestational diabetes mellitus effects (EMERGE): study protocol  Journal Articles
• A randomized trial of adding insulin glargine vs. avoidance of insulin in people with Type 2 diabetes on either no oral glucose‐lowering agents or submaximal doses of metformin and/or sulphonylureas. The Canadian INSIGHT (Implementing New Strategies with Insulin Glargine for Hyperglycaemia Treatment) Study  Journal Articles
• Addition of Metformin to Concurrent Chemoradiation in Patients With Locally Advanced Non–Small Cell Lung Cancer  Journal Articles
• Anabolic and anticatabolic agents used in burn care: What is known and what is yet to be learned  Journal Articles
• Antihyperglycemic Medications: A Claims-Based Estimate of First-line Therapy Use Prior to Initialization of Second-line Medications  Journal Articles
• Association of Metformin with Breast Cancer Incidence and Mortality in Patients with Type II Diabetes: A GRADE-Assessed Systematic Review and Meta-analysis  Journal Articles
• Availability and affordability of essential medicines for diabetes across high-income, middle-income, and low-income countries: a prospective epidemiological study  Journal Articles
• Bacteria transmit metformin-associated lifespan extension  Journal Articles
• Burn-induced hypermetabolism and skeletal muscle dysfunction  Journal Articles
• Cancer Antigen 15-3/Mucin 1 Levels in CCTG MA.32: A Breast Cancer Randomized Trial of Metformin vs Placebo  Journal Articles
• Cardiovascular and Other Outcomes Postintervention With Insulin Glargine and Omega-3 Fatty Acids (ORIGINALE)  Journal Articles
• Cardiovascular and metabolic effects of metformin in patients with type 1 diabetes (REMOVAL): a double-blind, randomised, placebo-controlled trial  Journal Articles
• Chronic Embryo‐Larval Exposure of Fathead Minnows to the Pharmaceutical Drug Metformin: Survival, Growth, and Microbiome Responses  Journal Articles
• Comparative Effects of Embryonic Metformin Exposure on Wild and Laboratory-Spawned Fathead Minnow (Pimephales promelas) Populations  Journal Articles
• Comparative risk of new-onset diabetes following commencement of antipsychotics in New Zealand: a population-based clustered multiple baseline time series design  Journal Articles
• Current Status of Chemoprevention in Barrett’s Esophagus  Journal Articles
• Design of FLAT-SUGAR: Randomized Trial of Prandial Insulin Versus Prandial GLP-1 Receptor Agonist Together With Basal Insulin and Metformin for High-Risk Type 2 Diabetes  Journal Articles
• Determinants of Weight Gain in the Action to Control Cardiovascular Risk in Diabetes Trial  Journal Articles
• Determinants of sustained stabilization of beta-cell function following short-term insulin therapy in type 2 diabetes  Journal Articles
• Diabetes remission and relapse following an intensive metabolic intervention combining insulin glargine/lixisenatide, metformin and lifestyle approaches: Results of a randomised controlled trial  Journal Articles
• Early Metformin in Gestational Diabetes  Conferences
• Effect of Metformin Versus Placebo on New Primary Cancers in Canadian Cancer Trials Group MA.32: A Secondary Analysis of a Phase III Randomized Double-Blind Trial in Early Breast Cancer  Journal Articles
• Effect of Metformin vs Placebo on Invasive Disease–Free Survival in Patients With Breast Cancer  Journal Articles
• Effect of Metformin vs Placebo on and Metabolic Factors in NCIC CTG MA.32  Journal Articles
• Effect of combining rosiglitazone with either metformin or insulin on β-cell mass and function in an animal model of Type 2 diabetes characterized by reduced β-cell mass at birth  Journal Articles
• Effectiveness of metformin to pregnant women with PCOS to reduce spontaneous abortion and gestational diabetes mellitus: a protocol for an overview of reviews  Journal Articles
• Effectiveness of pharmacological interventions for managing obesity in children and adolescents: A systematic review and meta-analysis framed using minimal important difference estimates based on GRADE guidance to inform a clinical practice guideline.  Journal Articles
• Effects of Metformin on Burn-Induced Hepatic Endoplasmic Reticulum Stress in Male Rats  Journal Articles
• Effects of metformin on wild fathead minnows (Pimephales promelas) using in-lake mesocosms in a boreal lake ecosystem  Journal Articles
• Effects of metformin versus placebo on vitamin B12 metabolism in non-diabetic breast cancer patients in CCTG MA.32  Journal Articles
• Evaluating remission of type 2 diabetes using a metabolic intervention including fixed-ratio insulin degludec and liraglutide: A randomized controlled trial.  Journal Articles
• Evaluation of metformin in early breast cancer: a modification of the traditional paradigm for clinical testing of anti-cancer agents  Journal Articles
• GDF15: emerging biology and therapeutic applications for obesity and cardiometabolic disease  Journal Articles
• Glucose Control in Severely Burned Patients Using Metformin  Journal Articles
• Growth Differentiation Factor 15 as a Novel Biomarker for Metformin  Journal Articles
• Growth differentiation factor 15 (GDF15) predicts relapse free and overall survival in unresected locally advanced non-small cell lung cancer treated with chemoradiotherapy.  Journal Articles
• Hyperinsulinemia Precedes Insulin Resistance in Mice Lacking Pancreatic β-Cell Leptin Signaling  Journal Articles
• Hypoglycemia and Incident Cognitive Dysfunction: A Post Hoc Analysis From the ORIGIN Trial  Journal Articles
• Impacts of metformin and aspirin on life history features and longevity of crickets: trade-offs versus cost-free life extension?  Journal Articles
• Impaired renal function modifies the risk of severe hypoglycaemia among users of insulin but not glyburide: a population-based nested case–control study  Journal Articles
• Insulin Resistance Postburn: Underlying Mechanisms and Current Therapeutic Strategies  Journal Articles
• Ionizing Radiation Activates AMP-Activated Kinase (AMPK): A Target for Radiosensitization of Human Cancer Cells  Journal Articles
• Is it Time to Test Metformin in Breast Cancer Prevention Trials? a Reply to the Authors  Journal Articles
• Low-dose combination therapy with rosiglitazone and metformin to prevent type 2 diabetes mellitus (CANOE trial): a double-blind randomised controlled study  Journal Articles
• Metformin Normalizes Type 2 Diabetes-Induced Decrease in Cell Proliferation and Neuroblast Differentiation in the Rat Dentate Gyrus  Journal Articles
• Metformin adapts its cellular effects to bioenergetic status in a model of metabolic dysfunction  Journal Articles
• Metformin alleviates muscle wasting post-thermal injury by increasing Pax7-positive muscle progenitor cells  Journal Articles
• Metformin ameliorates arsenic trioxide hepatotoxicity via inhibiting mitochondrial complex I  Journal Articles
• Metformin and salicylate synergistically activate liver AMPK, inhibit lipogenesis and improve insulin sensitivity  Journal Articles
• Metformin elicits anticancer effects through the sequential modulation of DICER and c-MYC  Journal Articles
• Metformin for chemo-radio-sensitization of NSCLC  Journal Articles
• Metformin for the management of peri‐operative hyperglycaemia  Journal Articles
• Metformin in Combination With Chemoradiotherapy in Locally Advanced Non–Small Cell Lung Cancer  Journal Articles
• Metformin in adults with type 1 diabetes: Design and methods of REducing with MetfOrmin Vascular Adverse Lesions (REMOVAL): An international multicentre trial  Journal Articles
• Metformin in women with type 2 diabetes in pregnancy (MiTy): a multicentre, international, randomised, placebo-controlled trial  Journal Articles
• Metformin increases peroxisome proliferator-activated receptor γ Co-activator-1α and utrophin a expression in dystrophic skeletal muscle  Journal Articles
• Metformin inhibits gluconeogenesis via a redox-dependent mechanism in vivo  Journal Articles
• Metformin inhibits growth and enhances radiation response of non-small cell lung cancer (NSCLC) through ATM and AMPK  Journal Articles
• Metformin or Oral Contraceptives for Adolescents With Polycystic Ovarian Syndrome: A Meta-analysis  Journal Articles
• Metformin prevents the pathological browning of subcutaneous white adipose tissue  Journal Articles
• Metformin therapy in pediatric type 2 diabetes mellitus and its comorbidities: A review  Journal Articles
• Metformin, diet and breast cancer: An avenue for chemoprevention  Journal Articles
• Metformin, placebo, and endocrine therapy discontinuation among participants in a randomized double-blind trial of metformin vs placebo in hormone receptor-positive early-stage breast cancer (CCTG MA32)  Conferences
• Metformin-induced increases in GDF15 are important for suppressing appetite and promoting weight loss  Journal Articles
• Metformin-induced metabolic reprogramming of chemoresistant ALDHbright breast cancer cells  Journal Articles
• Metformin-induced reductions in tumor growth involves modulation of the gut microbiome  Journal Articles
• Metformin: Metabolic Rewiring Faces Tumor Heterogeneity  Journal Articles
• Metformin—A Thought-provoking Addition to Anticancer Therapies—Reply  Journal Articles
• Monitoring Vitamin B12 in Women Treated with Metformin for Primary Prevention of Breast Cancer and Age-Related Chronic Diseases  Journal Articles
• Oral Pharmacologic Treatment of Type 2 Diabetes Mellitus: A Clinical Practice Guideline Update From the American College of Physicians  Journal Articles
• Oral antidiabetic drugs: bioavailability assessment of fixed-dose combination tablets of pioglitazone and metformin. Effect of body weight, gender, and race on systemic exposures of each drug.  Journal Articles
• Oral antidiabetic drugs: effect of food on absorption of pioglitazone and metformin from a fixed-dose combination tablet.  Journal Articles
• Pharmacologic Management of Type 2 Diabetes  Journal Articles
• Pharmacological interventions for prevention of weight gain in people with schizophrenia  Journal Articles
• Piloting a Remission Strategy in Type 2 Diabetes: Results of a Randomized Controlled Trial  Journal Articles
• Preventing type 2 diabetes using combination therapy: design and methods of the CAnadian Normoglycaemia Outcomes Evaluation (CANOE) trial  Journal Articles
• Pre‐prandial vs. post‐prandial capillary glucose measurements as targets for repaglinide dose titration in people with diet‐treated or metformin‐treated Type 2 diabetes: a randomized controlled clinical trial  Journal Articles
• Progression through diabetes therapies among new elderly users of metformin: a population‐based study  Journal Articles
• RCPE UK Consensus Statement on Diabetes  Conferences
• Remission of Type 2 Diabetes Following a Short-term Intensive Intervention With Insulin Glargine, Sitagliptin, and Metformin: Results of an Open-label Randomized Parallel-Design Trial  Journal Articles
• Remission of Type 2 Diabetes Following a Short-term Intervention With Insulin Glargine, Metformin, and Dapagliflozin  Journal Articles
• Safety and efficacy of dipeptidyl peptidase-4 inhibitors vs sulfonylurea in metformin-based combination therapy for type 2 diabetes mellitus: Systematic review and meta-analysis  Journal Articles
• Salicylate activates AMPK and synergizes with metformin to reduce the survival of prostate and lung cancer cells ex vivo through inhibition of de novo lipogenesis  Journal Articles
• Salsalate, but not metformin or canagliflozin, slows kidney cyst growth in an adult-onset mouse model of polycystic kidney disease  Journal Articles
• Short‐term intensive insulin as induction and maintenance therapy for the preservation of beta‐cell function in early type 2 diabetes (RESET‐IT Main): A 2‐year randomized controlled trial  Journal Articles
• Should family physicians prescribe medication for obesity? NO.  Journal Articles
• Similar cardiovascular outcomes in patients with diabetes and established or high risk for coronary vascular disease treated with dulaglutide with and without baseline metformin  Journal Articles
• Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin  Journal Articles
• THE ROLE OF HYPERGLYCEMIA IN BURNED PATIENTS  Journal Articles
• Targeting a phospho-STAT3-miRNAs pathway improves vesicular hepatic steatosis in an in vitro and in vivo model  Journal Articles
• Targeting stromal-induced pyruvate kinase M2 nuclear translocation impairs OXPHOS and prostate cancer metastatic spread  Journal Articles
• The AMPK agonist 5‐aminoimidazole‐4‐carboxamide ribonucleotide (AICAR), but not metformin, prevents inflammation‐associated cachectic muscle wasting  Journal Articles
• The Association of Basal Insulin Glargine and/or n-3 Fatty Acids With Incident Cancers in Patients With Dysglycemia  Journal Articles
• The Effect of Metformin on Mortality Following Cancer among Patients with Diabetes  Journal Articles
• The Effect of Metformin vs Placebo on Sex Hormones in Canadian Cancer Trials Group MA.32  Journal Articles
• The effect of adding metformin to insulin therapy for type 1 diabetes mellitus children: A systematic review and meta-analysis  Journal Articles
• The effectiveness and safety of treatments used for polycystic ovarian syndrome management in adolescents: a systematic review and network meta-analysis protocol  Journal Articles
• The effectiveness of hydroxychloroquine in patients with type 2 diabetes mellitus who are refractory to sulfonylureas—a randomized trial  Journal Articles
• The effects of metformin on endogenous androgens and SHBG in women: a systematic review and meta-analysis  Journal Articles
• The impact of oral hypoglycemics and statins on outcomes in myelodysplastic syndromes  Journal Articles
• There seem to be benefits from using local metformin as an adjuvant to scaling and root planing, but there is uncertainty about the magnitude  Journal Articles
• Trends in selection and timing of first‐line pharmacotherapy in older patients with Type 2 diabetes diagnosed between 1994 and 2006  Journal Articles
• Update and Next Steps for Real-World Translation of Interventions for Type 2 Diabetes Prevention: Reflections From a Diabetes Care Editors’ Expert Forum  Journal Articles
• What, How, and How Much Should Patients with Burns be Fed?  Journal Articles