Journal article
Effect of Metformin vs Placebo on Invasive Disease–Free Survival in Patients With Breast Cancer
Abstract
Importance: Metformin, a biguanide commonly used to treat type 2 diabetes, has been associated with potential beneficial effects across breast cancer subtypes in observational and preclinical studies.
Objective: To determine whether the administration of adjuvant metformin (vs placebo) to patients with breast cancer without diabetes improves outcomes.
Authors
Goodwin PJ; Chen BE; Gelmon KA; Whelan TJ; Ennis M; Lemieux J; Ligibel JA; Hershman DL; Mayer IA; Hobday TJ
Journal
JAMA: The Journal of the American Medical Association, Vol. 327, No. 20, pp. 1963–1973
Publisher
American Medical Association (AMA)
Publication Date
May 24, 2022
DOI
10.1001/jama.2022.6147
ISSN
0098-7484