Journal article
Effects of metformin versus placebo on vitamin B12 metabolism in non-diabetic breast cancer patients in CCTG MA.32
Abstract
BackgroundMetformin is associated with low levels of vitamin B12 (VitB12) in patients with diabetes. The CCTG/MA.32 trial investigates the effects of metformin vs placebo on breast cancer (BC) outcomes in non-diabetic high-risk BC patients. We analyzed VitB12 at baseline and after 6 months of metformin (versus placebo) in the first 492 patients with paired blood samples.MethodsVitB12 was analyzed centrally in baseline and 6-month fasting …
Authors
Lohmann AE; Liebman MF; Brien W; Parulekar WR; Gelmon KA; Shepherd LE; Ligibel JA; Hershman DL; Rastogi P; Mayer IA
Journal
Breast Cancer Research and Treatment, Vol. 164, No. 2, pp. 371–378
Publisher
Springer Nature
Publication Date
July 2017
DOI
10.1007/s10549-017-4265-x
ISSN
0167-6806