Journal article
Metformin in Combination With Chemoradiotherapy in Locally Advanced Non–Small Cell Lung Cancer
Abstract
IMPORTANCE: Unresected locally advanced non-small cell lung cancer (LA-NSCLC) shows poor survival outcomes even after aggressive concurrent chemoradiotherapy. Whether metformin, a diabetes agent that inhibits the mitochondria oxidative phosphorylation chain, could improve radiotherapy and chemotherapy response in LA-NSCLC remains to be studied.
OBJECTIVE: To examine whether metformin, given concurrently with chemoradiotherapy and as …
Authors
Tsakiridis T; Pond GR; Wright J; Ellis PM; Ahmed N; Abdulkarim B; Roa W; Robinson A; Swaminath A; Okawara G
Journal
JAMA Oncology, Vol. 7, No. 9, pp. 1333–1341
Publisher
American Medical Association (AMA)
Publication Date
September 1, 2021
DOI
10.1001/jamaoncol.2021.2328
ISSN
2374-2437