Journal article
Short‐term intensive insulin as induction and maintenance therapy for the preservation of beta‐cell function in early type 2 diabetes (RESET‐IT Main): A 2‐year randomized controlled trial
Abstract
AIM: To test the hypothesis that the addition of periodic courses of short-term intensive insulin therapy (IIT) could enhance the effect of metformin (MET) maintenance therapy on preservation of beta-cell function following induction IIT.
METHODS: In this multicentre, randomized controlled trial, 108 adults with type 2 diabetes (median 1.3 years' duration; HbA1c 6.6% ± 0.6%) were randomized to 3 weeks of induction IIT (glargine, lispro) …
Authors
Retnakaran R; Emery A; Ye C; Harris SB; Reichert SM; McInnes N; Gerstein HC; Thorpe KE; Kramer CK; Zinman B
Journal
Diabetes Obesity and Metabolism, Vol. 23, No. 8, pp. 1926–1935
Publisher
Wiley
Publication Date
August 2021
DOI
10.1111/dom.14421
ISSN
1462-8902