Andrew McArthur - McMaster Experts

Affiliations

Faculty of Health Sciences, McMaster University
Learning Portfolio Fellow, Paul R. MacPherson Institute for Leadership, Innovation and Excellence in Teaching, McMaster University
Member, Michael G. DeGroote Institute for Infectious Disease Research (IIDR), Faculty of Health Sciences
Professor, Biochemistry & Biomedical Sciences, Faculty of Health Sciences
Member, Centre for Metabolism, Obesity, and Diabetes Research (MODR), Faculty of Health Sciences
CEO & Owner, McArthur Bioinformatics,

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selected scholarly activity

chapters
- The origin and diversification of eukaryotes. 265-274. 2007
- A Biogeographical Perspective of the Deep-Sea Hydrothermal Vent Fauna. Advances in Marine Biology. 353-442. 1998
journal articles
- Diversity, functional classification and genotyping of SHV β-lactamases in Klebsiella pneumoniae.. Microbial Genomics. 10:001294. 2024
- Minimal Impact on the Resistome of Children in Botswana After Azithromycin Treatment for Acute Severe Diarrheal Disease. Journal of Infectious Diseases. 230:239-249. 2024
- Simultaneous detection of pathogens and antimicrobial resistance genes with the open source, cloud-based, CZ ID pipeline. bioRxiv. 5:2024.04.12.589250. 2024
- Chronic COVID-19 infection in an immunosuppressed patient shows changes in lineage over time: a case report. Virology Journal. 21:8. 2024
- A standardized nomenclature for resistance-modifying agents in the Comprehensive Antibiotic Resistance Database. Microbiology spectrum. 11:e0274423. 2023
- Macrophage AMPK β1 activation by PF-06409577 reduces the inflammatory response, cholesterol synthesis, and atherosclerosis in mice. iScience. 26:108269-108269. 2023
- THE DIRECT AMPK-β1 SELECTIVE ACTIVATOR PF-06409577 TARGETS MACROPHAGES TO REDUCE ATHEROSCLEROSIS IN MICE. Canadian Journal of Diabetes. 47:S198-S198. 2023
- THE DIRECT AMPK-β1 SELECTIVE ACTIVATOR PF-06409577 TARGETS MACROPHAGES TO REDUCE ATHEROSCLEROSIS IN MICE. Canadian Journal of Cardiology. 39:S238-S238. 2023
- Sensitivity to Neutralizing Antibodies and Resistance to Type I Interferons in SARS-CoV-2 R.1 Lineage Variants, Canada. Emerging Infectious Diseases. 29:1386-1396. 2023
- SARS-CoV-2 Outbreak Investigation Using Contact Tracing and Whole-Genome Sequencing in an Ontario Tertiary Care Hospital. Microbiology spectrum. 11:e0190022. 2023
- CARD*Shark: automated prioritization of literature curation for the Comprehensive Antibiotic Resistance Database. Database : the journal of biological databases and curation. 2023:baad023. 2023
- The DataHarmonizer: a tool for faster data harmonization, validation, aggregation and analysis of pathogen genomics contextual information. Microbial Genomics. 9:mgen000908. 2023
- CARD 2023: expanded curation, support for machine learning, and resistome prediction at the Comprehensive Antibiotic Resistance Database. Nucleic Acids Research (NAR). 51:D690-D699. 2023
- Exploring the mobilome and resistome of Enterococcus faecium in a One Health context across two continents. Microbial Genomics. 8. 2022
- Machine Learning for Antimicrobial Resistance Prediction: Current Practice, Limitations, and Clinical Perspective. Clinical Microbiology Reviews. 35:e0017921. 2022
- Capturing the antibiotic resistome of preterm infants reveals new benefits of probiotic supplementation. Microbiome. 10:136. 2022
- Metformin-induced reductions in tumor growth involves modulation of the gut microbiome. Molecular Metabolism. 61:101498-101498. 2022
- Performance Characteristics of Next-Generation Sequencing for the Detection of Antimicrobial Resistance Determinants in Escherichia coli Genomes and Metagenomes. mSystems. 7:e0002222. 2022
- Datasets for benchmarking antimicrobial resistance genes in bacterial metagenomic and whole genome sequencing. Scientific data. 9:341. 2022
- Enabling genomic island prediction and comparison in multiple genomes to investigate bacterial evolution and outbreaks. Microbial Genomics. 8. 2022
- Surface and Air Contamination With Severe Acute Respiratory Syndrome Coronavirus 2 From Hospitalized Coronavirus Disease 2019 Patients in Toronto, Canada, March–May 2020. Journal of Infectious Diseases. 225:768-776. 2022
- The pesticide chlorpyrifos promotes obesity by inhibiting diet-induced thermogenesis in brown adipose tissue. Nature Communications. 12:5163. 2021
- Evolutionary trajectory of SARS-CoV-2 and emerging variants. Virology Journal. 18:166. 2021
- Temporal Dynamics and Evolution of SARS-CoV-2 Demonstrate the Necessity of Ongoing Viral Genome Sequencing in Ontario, Canada. Clinical and Vaccine Immunology. 6:e00011-e00021. 2021
- The cytochrome P450 (CYP) superfamily in cnidarians. Scientific Reports. 11:9834. 2021
- The Pesticide Chlorpyrifos Promotes Obesity by Inhibiting Diet-Induced Thermogenesis. Journal of the Endocrine Society. 5:A59-A60. 2021
- Experimental and natural evidence of SARS-CoV-2-infection-induced activation of type I interferon responses. iScience. 24:102477-102477. 2021
- Structural Basis for Effector Transmembrane Domain Recognition by Type VI Secretion System Chaperones. The FASEB Journal. 35. 2021
- Identifying novel β-lactamase substrate activity through in silico prediction of antimicrobial resistance. Microbial Genomics. 7. 2021
- Recurrent multidrug-resistantSalmonella entericaserovar Typhimurium bacteremia in a returned traveller. Journal of the Association of Medical Microbiology and Infectious Disease Canada. 5:264-272. 2020
- Structural basis for effector transmembrane domain recognition by type VI secretion system chaperones. eLife. 9:e62816. 2020
- Strandedness during cDNA synthesis, the stranded parameter in htseq-count and analysis of RNA-Seq data. Briefings in Functional Genomics. 19:339-342. 2020
- Predicting the recombination potential of severe acute respiratory syndrome coronavirus 2 and Middle East respiratory syndrome coronavirus. Journal of General Virology. 101:1251-1260. 2020
- The origins and genomic diversity of American Civil War Era smallpox vaccine strains. Genome Biology. 21:175. 2020
- De novo necroptosis creates an inflammatory environment mediating tumor susceptibility to immune checkpoint inhibitors. Communications Biology. 3:645. 2020
- Overcoming Acquired and Native Macrolide Resistance with Bicarbonate. ACS Infectious Diseases. 6:2709-2718. 2020
- Isolation, Sequence, Infectivity, and Replication Kinetics of Severe Acute Respiratory Syndrome Coronavirus 2. Emerging Infectious Diseases. 26:2054-2063. 2020
- A Comparison of Whole Genome Sequencing of SARS-CoV-2 Using Amplicon-Based Sequencing, Random Hexamers, and Bait Capture. Viruses. 12:895-895. 2020
- Detection of Antimicrobial Resistance Using Proteomics and the Comprehensive Antibiotic Resistance Database: A Case Study. Proteomics - Clinical Applications. 14:e1800182. 2020
- Genotyping SARS-CoV-2 through an interactive web application. The Lancet Digital Health. 2:e340-e341. 2020
- Rapid Design of a Bait Capture Platform for Culture- and Amplification-Free Next-Generation Sequencing of SARS-CoV-2 2020
- CARD 2020: antibiotic resistome surveillance with the comprehensive antibiotic resistance database. Nucleic Acids Research (NAR). 48:D517-D525. 2020
- Capturing the Resistome: a Targeted Capture Method To Reveal Antibiotic Resistance Determinants in Metagenomes. Antimicrobial Agents and Chemotherapy. 64:e01324-e01319. 2019
- Metformin-induced increases in GDF15 are important for suppressing appetite and promoting weight loss. Nature Metabolism. 1:1202-1208. 2019
- An interbacterial toxin inhibits target cell growth by synthesizing (p)ppApp. Nature. 575:674-678. 2019
- Phylogenetic reconciliation reveals the natural history of glycopeptide antibiotic biosynthesis and resistance. Nature Microbiology. 4:1862-1871. 2019
- Failed Recovery of Glycemic Control and Myofibrillar Protein Synthesis With 2 wk of Physical Inactivity in Overweight, Prediabetic Older Adults. The journals of gerontology. Series A, Biological sciences and medical sciences. 73:1070-1077. 2018
- Genetic population structure of the round whitefish (Prosopium cylindraceum) in North America: multiple markers reveal glacial refugia and regional subdivision. Canadian Journal of Fisheries and Aquatic Sciences. 75:836-849. 2018
- Functional relatedness in the Inv/Mxi‐Spa type III secretion system family. Molecular Microbiology. 103:973-991. 2017
- CARD 2017: expansion and model-centric curation of the comprehensive antibiotic resistance database. Nucleic Acids Research (NAR). 45:D566-D573. 2017
- Antimicrobial resistance surveillance in the genomic age. Annals of the New York Academy of Sciences. 1388:78-91. 2017
- A diverse intrinsic antibiotic resistome from a cave bacterium. Nature Communications. 7:13803. 2016
- The transcription factor, Nuclear factor, erythroid 2 (Nfe2), is a regulator of the oxidative stress response during Danio rerio development. Aquatic Toxicology. 180:141-154. 2016
- YphC and YsxC GTPases assist the maturation of the central protuberance, GTPase associated region and functional core of the 50S ribosomal subunit. Nucleic Acids Research (NAR). 44:8442-8455. 2016
- Gene duplication and divergence produce divergent MHC genotypes without disassortative mating. Molecular Ecology. 25:4355-4367. 2016
- Impacts of degraded DNA on restriction enzyme associated DNA sequencing (RADSeq). Molecular Ecology Resources. 15:1304-1315. 2015
- Bioinformatics of antimicrobial resistance in the age of molecular epidemiology. Current Opinion in Microbiology. 27:45-50. 2015
- IslandViewer 3: more flexible, interactive genomic island discovery, visualization and analysis: Figure 1.. Nucleic Acids Research (NAR). 43:W104-W108. 2015
- Non-neutral evolution and reciprocal monophyly of two expressed Mhc class II B genes in Leach’s storm-petrel. Immunogenetics. 67:111-123. 2015
- Clinical utilization of genomics data produced by the international Pseudomonas aeruginosa consortium. Frontiers in Microbiology. 6:1036. 2015
- Gene expression changes during Giardia–host cell interactions in serum-free medium. Molecular and Biochemical Parasitology. 197:21-23. 2014
- Inhibition of endogenous MTF-1 signaling in zebrafish embryos identifies novel roles for MTF-1 in development. Biochimica et Biophysica Acta: international journal of biochemistry and biophysics. 1843:1818-1833. 2014
- The Transcriptional Response to Oxidative Stress during Vertebrate Development: Effects of tert-Butylhydroquinone and 2,3,7,8-Tetrachlorodibenzo-p-Dioxin. PLoS ONE. 9:e113158-e113158. 2014
- The Comprehensive Antibiotic Resistance Database. Antimicrobial Agents and Chemotherapy. 57:3348-3357. 2013
- Developmental Expression of the Nfe2-Related Factor (Nrf) Transcription Factor Family in the Zebrafish, Danio rerio. PLoS ONE. 8:e79574-e79574. 2013
- Nrf2b, Novel Zebrafish Paralog of Oxidant-responsive Transcription Factor NF-E2-related Factor 2 (NRF2). Journal of Biological Chemistry. 287:4609-4627. 2012
- Molecular typing of M. tuberculosis isolates from Yaoundé reveals RIF resistance markers, clonal relatedness and mutation patterns. Asian Pacific Journal of Tropical Disease. 2:342-347. 2012
- A Small Molecule Discrimination Map of the Antibiotic Resistance Kinome. Cell Chemical Biology. 18:1591-1601. 2011
- An atypical proprotein convertase in Giardia lamblia differentiation. Molecular and Biochemical Parasitology. 175:169-180. 2011
- Phylogenetic and Functional Analysis of the Vertebrate Cytochrome P450 2 Family. Journal of Molecular Evolution. 72:56-71. 2011
- Identification and developmental expression of the full complement of Cytochrome P450 genes in Zebrafish. BMC Genomics. 11:643. 2010
- Transcriptome analyses of the Giardia lamblia life cycle. Molecular and Biochemical Parasitology. 174:62-65. 2010
- Plasmodium possesses dynein light chain classes that are unique and conserved across species. Infection, Genetics and Evolution. 9:337-343. 2009
- Transcriptome analysis ofSchistosoma mansonilarval development using serial analysis of gene expression (SAGE). Parasitology. 136:469-485. 2009
- Differential Gene Expression between Fall‐ and Spring‐Run Chinook Salmon Assessed by Long Serial Analysis of Gene Expression. Transactions of the American Fisheries Society. 137:1378-1388. 2008
- Profiling Schistosoma mansoni development using serial analysis of gene expression (SAGE). Experimental Parasitology. 117:246-258. 2007
- Genomic Minimalism in the Early Diverging Intestinal Parasite Giardia lamblia. Science. 317:1921-1926. 2007
- Molecular evolution of the vesicle coat component βCOP in Toxoplasma gondii. Molecular Phylogenetics and Evolution. 44:1284-1294. 2007
- A functionally divergent hydrogenosomal peptidase with protomitochondrial ancestry. Molecular Microbiology. 64:1154-1163. 2007
- Protein phosphatase 2A plays a crucial role in Giardia lamblia differentiation. Molecular and Biochemical Parasitology. 152:80-89. 2007
- A New Family of Giardial Cysteine-Rich Non-VSP Protein Genes and a Novel Cyst Protein. PLoS ONE. 1:e44-e44. 2006
- Nitric oxide-dependent changes in Schistosoma mansoni gene expression. Molecular and Biochemical Parasitology. 150:367-370. 2006
- Proteins of the Glycine Decarboxylase Complex in the Hydrogenosome ofTrichomonas vaginalis. Clinical and Vaccine Immunology. 5:2062-2071. 2006
- Schistosoma mansoni albumin, a major defense against oxidative damage, was acquired by lateral gene transfer from a mammalian host. Molecular and Biochemical Parasitology. 150:359-363. 2006
- In Vitro Generation of Human High-Density-Lipoprotein-Resistant Trypanosoma brucei brucei. Clinical and Vaccine Immunology. 5:1276-1286. 2006
- Long Serial Analysis of Gene Expression for Gene Discovery and Transcriptome Profiling in the Widespread Marine Coccolithophore Emiliania huxleyi. Applied and Environmental Microbiology. 72:252-260. 2006
- Developmental changes in the adhesive disk during Giardia differentiation. Molecular and Biochemical Parasitology. 141:199-207. 2005
- Annexin-like alpha giardins: a new cytoskeletal gene family in Giardia lamblia. International Journal for Parasitology. 35:617-626. 2005
- Characterization of a cetacean aromatase (CYP19) and the phylogeny and functional conservation of vertebrate aromatase. General and Comparative Endocrinology. 140:74-83. 2005
- Evolution of Eukaryotic Transcription: Insights From the Genome of Giardia lamblia. Genome Research. 14:1537-1547. 2004
- Phylogenetic Analysis of the Cytochrome P450 3 (CYP3) Gene Family. Journal of Molecular Evolution. 57:200-211. 2003
- Giardia lamblia RNA Polymerase II. Journal of Biological Chemistry. 278:27804-27810. 2003
- Iron-Dependent Hydrogenases ofEntamoeba histolyticaandGiardia lamblia:Activity of the Recombinant Entamoebic Enzyme and Evidence for Lateral Gene Transfer. Biological Bulletin. 204:1-9. 2003
- A novel Myb‐related protein involved in transcriptional activation of encystation genes in Giardia lamblia. Molecular Microbiology. 46:971-984. 2002
- Evidence for Lateral Transfer of Genes Encoding Ferredoxins, Nitroreductases, NADH Oxidase, and Alcohol Dehydrogenase 3 from Anaerobic Prokaryotes to Giardia lamblia and Entamoeba histolytica. Clinical and Vaccine Immunology. 1:181-190. 2002
- A spliceosomal intron in Giardia lamblia. Proceedings of the National Academy of Sciences of the United States of America. 99:3701-3705. 2002
- The Evolutionary Origins of Eukaryotic Protein Disulfide Isomerase Domains: New Evidence from the Amitochondriate Protist Giardia lamblia. Molecular Biology and Evolution (MBE). 18:1455-1463. 2001
- Phylogenetic relationships within the Octocorallia (Cnidaria: Anthozoa) based on nuclear 18S rRNA sequences. Marine Biology. 138:235-246. 2001
- A molecular phylogeny of the Patellogastropoda (Mollusca: Gastropoda). Marine Biology. 137:183-194. 2000
- Ancyromonadida: A New Phylogenetic Lineage Among the Protozoa Closely Related to the Common Ancestor of Metazoans, Fungi, and Choanoflagellates (Opisthokonta). Journal of Molecular Evolution. 51:278-285. 2000
- Core Histones of the Amitochondriate Protist, Giardia lamblia. Molecular Biology and Evolution (MBE). 17:1156-1163. 2000
- TheGiardiagenome project database. FEMS Microbiology Letters. 189:271-273. 2000
- Partial 28S rDNA Sequences and the Antiquity of Hydrothermal Vent Endemic Gastropods. Molecular Phylogenetics and Evolution. 13:255-274. 1999
- Relics and antiquity revisited in the modern vent fauna. Geological Society Special Publication. 148:271-291. 1998
- Plate tectonic history and hot vent biogeography. Tectonic, magmatic, hydrothermal and biological segmentation of mid-ocean ridges. 225-238. 1996
- Plate tectonic history and hot vent biogeography. Geological Society Special Publication. 118:225-238. 1996
- Human micronucleus counts are correlated with age, smoking, and cesium-137 dose in the Goiânia (Brazil) radiological accident. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS. 313:57-68. 1994
- Metformin-induced increases in GDF15 are important for suppressing appetite and promoting weight loss. Yearbook of Paediatric Endocrinology.
- PCR Detection of Mixed and Zoonoses Malaria Using Plasmodium spp Dynein Light Chain (dlc-tctex) Gene. Annual Research and Review in Biology. 32:1-12.
preprints