Journal article
The Transcriptional Response to Oxidative Stress during Vertebrate Development: Effects of tert-Butylhydroquinone and 2,3,7,8-Tetrachlorodibenzo-p-Dioxin
Abstract
Oxidative stress is an important mechanism of chemical toxicity, contributing to teratogenesis and to cardiovascular and neurodegenerative diseases. Developing animals may be especially sensitive to chemicals causing oxidative stress. The developmental expression and inducibility of anti-oxidant defenses through activation of NF-E2-related factor 2 (NRF2) affect susceptibility to oxidants, but the embryonic response to oxidants is not well …
Authors
Hahn ME; McArthur AG; Karchner SI; Franks DG; Jenny MJ; Timme-Laragy AR; Stegeman JJ; Woodin BR; Cipriano MJ; Linney E
Journal
PLOS ONE, Vol. 9, No. 11,
Publisher
Public Library of Science (PLoS)
DOI
10.1371/journal.pone.0113158
ISSN
1932-6203