The cytochrome P450 (CYP) superfamily in cnidarians Journal Articles

abstract

• AbstractThe cytochrome P450 (CYP) superfamily is a diverse and important enzyme family, playing a central role in chemical defense and in synthesis and metabolism of major biological signaling molecules. The CYPomes of four cnidarian genomes (Hydra vulgaris, Acropora digitifera, Aurelia aurita, Nematostella vectensis) were annotated; phylogenetic analyses determined the evolutionary relationships amongst the sequences and with existing metazoan CYPs. 155 functional CYPs were identified and 90 fragments. Genes were from 24 new CYP families and several new subfamilies; genes were in 9 of the 12 established metazoan CYP clans. All species had large expansions of clan 2 diversity, with H. vulgaris having reduced diversity for both clan 3 and mitochondrial clan. We identified potential candidates for xenobiotic metabolism and steroidogenesis. That each genome contained multiple, novel CYP families may reflect the large evolutionary distance within the cnidarians, unique physiology in the cnidarian classes, and/or different ecology of the individual species.

authors

• Pankov, Kirill V
• McArthur, Andrew
• Gold, David A
• Nelson, David R
• Goldstone, Jared V
• Wilson, Joanna

publication date

• May 10, 2021

has subject area

• Animals (MeSH)
• Biological Evolution (MeSH)
• Cnidaria (MeSH)
• Cytochrome P-450 Enzyme System (MeSH)
• Genome (MeSH)
• Multigene Family (MeSH)
• Phylogeny (MeSH)
• Xenobiotics (MeSH)

published in

• Scientific Reports  Journal

keywords

• Animals
• Biological Evolution
• Cnidaria
• Cytochrome P-450 Enzyme System
• Genome
• Multigene Family
• Phylogeny
• Xenobiotics

Digital Object Identifier (DOI)

• 10.1038/s41598-021-88700-y

start page

• 9834

volume

• 11

issue

• 1