Temporal Dynamics and Evolution of SARS-CoV-2 Demonstrate the Necessity of Ongoing Viral Genome Sequencing in Ontario, Canada Journal Articles

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abstract

Genome-wide variation in SARS-CoV-2 reveals evolution and transmission dynamics which are critical considerations for disease control and prevention decisions. Here, we review estimates of the genome-wide viral mutation rates, summarize current COVID-19 case load in the province of Ontario, Canada (5 January 2021), and analyze published SARS-CoV-2 genomes from Ontario (collected prior to 24 November 2020) to test for more infectious genetic variants or lineages.

authors

Sjaarda, Calvin P
Guthrie, Jennifer L
Mubareka, Samira
Simpson, Jared T
Hamelin, Bettina
Wong, Henry
Mortimer, Leanne
Slinger, Robert
McArthur, Andrew
Desjardins, Marc
McGeer, Allison
Mazzulli, Tony
Douchant, Katya
Brabant-Kirwan, Danielle
Fattouh, Ramzi
Campigotto, Aaron
Patel, Samir N
Fittipaldi, Nahuel
Colautti, Robert I
Sheth, Prameet M

status

published

publication date

June 30, 2021

has subject area

1107 Immunology (FoR)
Base Sequence (MeSH)
COVID-19 (MeSH)
Genetic Variation (MeSH)
Genome, Viral (MeSH)
Humans (MeSH)
Immunology (Science Metrix)
Microbiology (Science Metrix)
Mutation Rate (MeSH)
Ontario (MeSH)
Phylogeny (MeSH)
SARS-CoV-2 (MeSH)
Sequence Analysis, RNA (MeSH)
Spike Glycoprotein, Coronavirus (MeSH)

published in

Clinical and Vaccine Immunology Journal