The transcription factor, Nuclear factor, erythroid 2 (Nfe2), is a regulator of the oxidative stress response during Danio rerio development

Abstract

Development is a complex and well-defined process characterized by rapid cell proliferation and apoptosis. At this stage in life, a developmentally young organism is more sensitive to toxicants as compared to an adult. In response to pro-oxidant exposure, members of the Cap'n'Collar (CNC) basic leucine zipper (b-ZIP) transcription factor family (including Nfe2 and Nfe2-related factors, Nrfs) activate the expression of genes whose protein …

Authors

Williams LM; Lago BA; McArthur AG; Raphenya AR; Pray N; Saleem N; Salas S; Paulson K; Mangar RS; Liu Y

Journal

Aquatic Toxicology, Vol. 180, , pp. 141–154

Publisher

Elsevier

Publication Date

November 2016

DOI

10.1016/j.aquatox.2016.09.019

ISSN

0166-445X

Associated Experts

Andrew McArthur

Professor, Faculty of Health Sciences

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