selected scholarly activity
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chapters
- Use of Rapid Response Team Protocols. 189-194. 2025
- The Treatment of Sepsis: From Failed Therapies to New Possibilities. 221-231. 2016
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conferences
- Moral Distress and Other Wellness Measures in Canadian Critical Care Physicians. Annals of the American Thoracic Society. 1343-1351. 2021
- Single step separation and concentration of biomarker proteins using agarose based miniaturized isoelectric gates for point of care diagnostics. Sensors and Actuators, B: Chemical. 2021
- Parallel Electroplating of Multiple Materials Using Patterned Gels for Electrochemical Sensing. Proceedings of IEEE Sensors. 2019
- PC224 Thrombin-Mediated Human Aortic Endothelial Barrier Dysfunction Alters MicroRNA Pathways Involved in Cell Survival, Injury, and Cancer. Journal of Vascular Surgery. 200S-200S. 2017
- Thrombin-Mediated Human Aortic Endothelial Barrier Dysfunction Alters Microrna Pathways Involved in Cell Survival, Injury, and Cancer. Arteriosclerosis, Thrombosis and Vascular Biology. 2017
- Cycle Pilot Rct: A Multicenter Feasibility Study Of Early In-Bed Cycling Versus Routine Physiotherapy In Medical- Surgical Ventilated Patients. American Journal of Respiratory and Critical Care Medicine. 2017
- Noise Control In Acute Care Units: A Systematic Review And Meta-Analysis Of Randomized Controlled Trials. American Journal of Respiratory and Critical Care Medicine. 2017
- Enhanced Culturing Techniques Identify Unexpected Pathogens In Patients With Suspected Ventilator-Associated Infections: The Fast Identification Of Pathogens (findpath) Pilot Study. American Journal of Respiratory and Critical Care Medicine. 2016
- Biological Rational for the Use of Heparin in Septic Shock: Translational Data from the Halo Pilot RCT. Blood. 2336-2336. 2015
- Impact of PCSK9 in a murine mouse model of sepsis. Journal of Thrombosis and Haemostasis. 379-379. 2015
- Source data verification pilot: using central monitoring in an: observational critical care biomarker study. Journal of Thrombosis and Haemostasis. 403-403. 2015
- Ards Treatment Strategies And Protocols: Availability In 25 Tertiary Care Icus. American Journal of Respiratory and Critical Care Medicine. 2015
- The Optimal Vasopressor Titration (ovation) Pilot Randomized Controlled Trial. American Journal of Respiratory and Critical Care Medicine. 2015
- POST-INTUBATION HEMODYNAMIC INSTABILITY IN CRITICALLY ILL INTENSIVE CARE UNIT PATIENTS: A MULTICENTER STUDY. Intensive Care Medicine. S218-S218. 2014
- Microfluidic device for clinical outcome prediction of severe sepsis. 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014. 1036-1038. 2014
- Monitoring Of Medical And Surgical Patients In Mulago Hospital, Uganda: A Pilot Observational Study Using The Modified Early Warning Score. American Journal of Respiratory and Critical Care Medicine. 2014
- One Year Survival and Predictors of Mortality in Cardiac Surgery Patients With Prolonged Intensive Care Unit Stay. Canadian Journal of Cardiology. S205-S206. 2013
- Role of cell-free DNA in sepsis pathophysiology: novel studies in murine models of sepsis. Journal of Thrombosis and Haemostasis. 37-38. 2013
- DEFERRED CONSENT IN A LOW RISK OBSERVATIONAL STUDY: OPTIMIZING RECRUITMENT IN CRITICALLY ILL PATIENTS. Critical Care Medicine. U50-U50. 2012
- Effects of fluids on the liver microcirculation and cell free DNA in sepsis. The FASEB Journal. 2012
- Syndecan-1 modulates leukocyte adhesion in the murine parietal peritoneum microcirculation in response to Staphylococcus aureus lipotechoic acid. The FASEB Journal. 2012
- ROLE OF CELL-FREE DNA IN SEPSIS PATHOPHYSIOLOGY: NOVEL STUDIES IN MURINE MODELS OF SEPSIS. Shock. 30-30. 2012
- EFFECTS OF NOVEL RESUSCITATION FLUIDS ON THE HEPATIC MICROCIRCULATION IN NAIVE AND ENDOTOXEMIC MICE. Shock. 77-77. 2011
- TEMPORAL CHANGES IN CYTOKINES AND CHEMOKINES IN EARLY SUSPECTED SEPTIC SHOCK. Shock. 78-78. 2011
- BLINDING ALBUMIN AND NORMAL SALINE FOR THE PRECISE PILOT MULTI-CENTRE FLUID RESUSCITATION TRIAL: A DESCRIPTION OF THE PROCEDURE. Intensive Care Medicine. S424-S424. 2010
- Effects of a 4 Hour Exposure to Conventional Peritoneal Dialysis Fluids on the Murine Hepatic Microcirculation. The FASEB Journal. 2010
- Response of the Murine Urinary Bladder Microcirculation to Lipopolysaccharide from Escherichia coli and Pseudomonas aeruginosa. The FASEB Journal. 2010
- Acute Exposure to Conventional Peritoneal Dialysis Fluids Does Not Alter the Hepatic Microcirculation. The FASEB Journal. 2009
- Effects of Peritoneal Dialysis Solutions on the Murine Peritoneal Microcirculation. The FASEB Journal. 2009
- Intravital Microscopy of the Murine Urinary Bladder Microcirculation. The FASEB Journal. 2009
- Transfused human alpha-1-acid glycoprotein attenuates hepatic inflammation in mice more effectively than human albumin. Transfusion. 147A-147A. 2008
- Normal saline resuscitation induces increased sinusoidal MIP-2 expression in early sepsis. The FASEB Journal. 2008
- Characterization of the hepatic endothelial glycocalyx of sialidase deficient mice in response to TNFα. The FASEB Journal. 2008
- Is immune phenotype important in early sepsis?. The FASEB Journal. A1264-A1264. 2005
- Hepatic leukocyte recruitment in response to prolonged expression of TNF alpha and IL-1 beta. The FASEB Journal. A758-A758. 2005
- ETHYL PYRUVATE MODULATES HEPATIC INFLAMMATION DURING EARLY SEPSIS.. Shock. 65-66. 2004
- Is acid suppression necessary in early polymicrobial sepsis?. The FASEB Journal. A1267-A1267. 2004
- The hepatic microcirculation in a model of recurrent colitis. The FASEB Journal. A659-A659. 2004
- Molecular mechanisms of hepatic leukocyte recruitment in early sepsis. The FASEB Journal. A419-A420. 2003
- Pentastarch reduces hepatic leukocyte recruitment in sepsis. The FASEB Journal. A82-A83. 2002
- Hepatic leukocyte recruitment in Inflammatory Bowel Disease. Gastroenterology. A185-A185. 2001
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journal articles
- Decoding Analyses Show Dynamic Waxing and Waning of Event-Related Potentials in Coma Patients.. Brain Sciences. 15:189. 2025
- Propranolol As an Anxiolytic to Reduce the Use of Sedatives for Critically Ill Adults Receiving Mechanical Ventilation (PROACTIVE): An Open-Label Randomized Controlled Trial.. Critical Care Medicine. 53:e257-e268. 2025
- Sepsis research in Canada: An environmental scan of sepsis investigators, research, and funding.. PLOS Global Public Health. 5:e0003606. 2025
- Sepsis subtypes and differential treatment response to vitamin C: biological sub-study of the LOVIT trial.. Intensive Care Medicine. 51:82-93. 2025
- Correction: Characterizing usual-care physical rehabilitation in Canadian intensive care unit patients: a secondary analysis of the Canadian multicentre Critical Care Cycling to Improve Lower Extremity Strength pilot randomized controlled trial.. Canadian Journal of Anaesthesia. 71:1573. 2024
- Unraveling the impact of operational parameters and environmental conditions on the quality of viable bacterial aerosols.. PNAS Nexus. 3:pgae473. 2024
- Early In-Bed Cycle Ergometry With Critically Ill, Mechanically Ventilated Patients: Statistical Analysis Plan for CYCLE (Critical Care Cycling to Improve Lower Extremity Strength), an International, Multicenter, Randomized Clinical Trial.. JMIR Research Protocols. 13:e54451. 2024
- Topical Versus Intravenous Tranexamic Acid in Patients Undergoing Cardiac Surgery: The DEPOSITION Randomized Controlled Trial. Circulation. 150:1315-1323. 2024
- Characterizing usual-care physical rehabilitation in Canadian intensive care unit patients: a secondary analysis of the Canadian multicentre Critical Care Cycling to Improve Lower Extremity Strength pilot randomized controlled trial.. Canadian Journal of Anaesthesia. 71:1406-1416. 2024
- Social determinants of health and sepsis: a case-control study. Canadian Journal of Anaesthesia. 71:1397-1405. 2024
- Reducing the burden of preventable deaths from sepsis in Canada: A need for a national sepsis action plan. Healthcare Management Forum. 37:366-370. 2024
- Liberal or Restrictive Transfusion Strategy in Patients with Traumatic Brain Injury. New England Journal of Medicine. 391:722-735. 2024
- The value of nursing intuition. Intensive and Critical Care Nursing. 83:103714-103714. 2024
- Methylene Blue in Septic Shock: A Systematic Review and Meta-Analysis. Critical Care Explorations. 6:e1110-e1110. 2024
- The response of Canada’s clinical health research ecosystem to the COVID-19 pandemic. CANADIAN MEDICAL ASSOCIATION JOURNAL. 196:E779-E788. 2024
- Correction: Sepsis and obesity: a scoping review of diet-induced obesity murine models. Intensive Care Medicine Experimental. 12:52. 2024
- Statistical analysis plan for the SQUEEZE trial: A trial to determine whether septic shock reversal is quicker in pediatric patients randomized to an early goal-directed fluid-sparing strategy vs. usual care (SQUEEZE). Critical Care and Resuscitation. 26:123-134. 2024
- Impact of age on the host response to sepsis in a murine model of fecal-induced peritonitis. Intensive Care Medicine Experimental. 12:28. 2024
- Sepsis and obesity: a scoping review of diet-induced obesity murine models. Intensive Care Medicine Experimental. 12:15. 2024
- Executive Summary: Society of Critical Care Medicine Guidelines on Recognizing and Responding to Clinical Deterioration Outside the ICU. Critical Care Medicine. 52:307-313. 2024
- REVIEWING THE DYSREGULATION OF ADAMTS13 AND VWF IN SEPSIS. Shock. 61:189-196. 2024
- Sepsis policy, guidelines and standards in Canada: a jurisdictional scoping review protocol. BMJ Open. 14:e077909-e077909. 2024
- Society of Critical Care Medicine Guidelines on Recognizing and Responding to Clinical Deterioration Outside the ICU: 2023. Critical Care Medicine. 52:314-330. 2024
- Impact of sample processing delays on plasma markers of inflammation, chemotaxis, cell death, and blood coagulation.. PLoS ONE. 19:e0311921. 2024
- The authors reply. Critical Care Medicine. 51:e283-e284. 2023
- A Hospital-Wide Open-Label Cluster Crossover Pragmatic Comparative Effectiveness Randomized Trial Comparing Normal Saline to Ringer’s Lactate: Protocol and Statistical Analysis Plan of The FLUID Trial. JMIR Research Protocols. 12:e51783-e51783. 2023
- IV Vitamin C in Adults With Sepsis: A Bayesian Reanalysis of a Randomized Controlled Trial*. Critical Care Medicine. 51:e152-e156. 2023
- Development and characterization of a fecal-induced peritonitis model of murine sepsis: results from a multi-laboratory study and iterative modification of experimental conditions. Intensive Care Medicine Experimental. 11:45. 2023
- Critical Care Cycling to ImproveLowerExtremity Strength (CYCLE): protocol for an international, multicentre randomised clinical trial of early in-bed cycling for mechanically ventilated patients. BMJ Open. 13:e075685-e075685. 2023
- Sepsis: network pathophysiology and implications for early diagnosis. American Journal of Physiology. Regulatory Integrative and Comparative Physiology. 324:R613-R624. 2023
- Sex-based analysis of treatment responses in animal models of sepsis: a preclinical systematic review protocol. Systematic Reviews. 12:50. 2023
- FLUID trial: a hospital-wide open-label cluster cross-over pragmatic comparative effectiveness randomised pilot trial comparing normal saline to Ringer’s lactate. BMJ Open. 13:e067142-e067142. 2023
- Collecting Race-Based Data in Health Research: A Critical Analysis of the Ongoing Challenges and Next Steps for Canada. BioéthiqueOnline. 6:75-80. 2023
- Cross-immunity against SARS-COV-2 variants of concern in naturally infected critically ill COVID-19 patients. Trials in Vaccinology. 9:e12704-e12704. 2023
- Tracking auditory mismatch negativity responses during full conscious state and coma. Frontiers in Neurology. 14:1111691. 2023
- Wellness and Coping of Physicians Who Worked in ICUs During the Pandemic: A Multicenter Cross-Sectional North American Survey*. Critical Care Medicine. 50:1689-1700. 2022
- Public awareness and knowledge of sepsis: a cross-sectional survey of adults in Canada. Critical Care. 26:337. 2022
- Haemoglobin transfusion threshold in traumatic brain injury optimisation (HEMOTION): a multicentre, randomised, clinical trial protocol. BMJ Open. 12:e067117-e067117. 2022
- Research interrupted: applying the CONSERVE 2021 Statement to a randomized trial of rehabilitation during critical illness affected by the COVID-19 pandemic. Trials. 23:735. 2022
- The experiences of cardiac surgery critical care clinicians with in-bed cycling in adult patients undergoing complex cardiac surgery. Disability and Rehabilitation. 44:5038-5045. 2022
- Patient, Public, and Healthcare Professional’s Sepsis Awareness, Knowledge, and Information Seeking Behaviors: A Scoping Review. Critical Care Medicine. 50:1187-1197. 2022
- Stressing the endoplasmic reticulum response as a diagnostic tool for sepsis. ANNALS OF TRANSLATIONAL MEDICINE. 10:812-812. 2022
- Chlorhexidine (di)gluconate locking device for central line infection prevention in intensive care unit patients: a multi-unit, pilot randomized controlled trial. British Journal of Nursing. 31:S36-S46. 2022
- Probe design for simultaneous, targeted capture of diverse metagenomic targets. Cell Reports Methods. 2:100246-100246. 2022
- Social Determinants of Health Associated With the Development of Sepsis in Adults: A Scoping Review. Critical Care Explorations. 4:e0731-e0731. 2022
- Microfluidic device for single step measurement of protein C in plasma samples for sepsis prognosis. Lab on a Chip. 22:2566-2577. 2022
- Single-step measurement of cell-free DNA for sepsis prognosis using a thread-based microfluidic device. Mikrochimica Acta. 189:146. 2022
- The prognostic utility of protein C as a biomarker for adult sepsis: a systematic review and meta-analysis. Critical Care. 26:21. 2022
- Identification and Assessment of Strategies to Address Gender Inequity in the Specialty of Critical Care Medicine: A Scoping Review, Modified Consensus Process, and Stakeholder Meeting. Critical Care Explorations. 4:e0612-e0612. 2022
- Survey of Physiotherapy Practice in Ontario Cardiac Surgery Intensive Care Units. Physiotherapy Canada. Physiotherapie Canada. 74:25-32. 2022
- CardiO Cycle: a pilot feasibility study of in-bed cycling in critically ill patients post cardiac surgery. Pilot and Feasibility Studies. 7:13. 2021
- National Preclinical Sepsis Platform: developing a framework for accelerating innovation in Canadian sepsis research. Intensive Care Medicine Experimental. 9:14. 2021
- Restricted visitation policies in acute care settings during the COVID-19 pandemic: a scoping review. Critical Care. 25:347. 2021
- A Modified Delphi Process to Prioritize Experiences and Guidance Related to ICU Restricted Visitation Policies During the Coronavirus Disease 2019 Pandemic. Critical Care Explorations. 3:e0562-e0562. 2021
- An environmental scan of visitation policies in Canadian intensive care units during the first wave of the COVID-19 pandemic. Canadian Journal of Anaesthesia. 68:1474-1484. 2021
- Probe design for simultaneous, targeted capture of diverse metagenomic targets. Cell Reports Methods. 1:100069-100069. 2021
- Diagnostic and prognostic accuracy of Protein C in adult patients with sepsis: protocol for a systematic review and meta-analysis. BMJ Open. 11:e050754-e050754. 2021
- Impact of restricted visitation policies in hospitals on patients, family members and healthcare providers during the COVID-19 pandemic: a scoping review protocol. BMJ Open. 11:e048227-e048227. 2021
- The Societies’ Responsibility for Wellness: Healing for the Healer. Annals of the American Thoracic Society. 18:1458-1460. 2021
- Sex- and Gender-Dependent Differences in Clinical and Preclinical Sepsis. Shock. 56:178-187. 2021
- Biomarkers of coagulation, endothelial function, and fibrinolysis in critically ill patients with COVID‐19: A single‐center prospective longitudinal study. Journal of Thrombosis and Haemostasis. 19:1546-1557. 2021
- The Effects of Biological Sex on Sepsis Treatments in Animal Models: A Systematic Review and a Narrative Elaboration on Sex- and Gender-Dependent Differences in Sepsis. Critical Care Explorations. 3:e0433-e0433. 2021
- Diagnostic Potential of Coagulation-Related Biomarkers for Sepsis in the Emergency Department: Protocol for a Pilot Observational Cohort Study. Critical Care Explorations. 3:e0414-e0414. 2021
- Dosing Fluids in Early Septic Shock. Chest. 159:1493-1502. 2021
- Single step separation and concentration of biomarker proteins using agarose based miniaturized isoelectric gates for point of care diagnostics. Sensors and Actuators, B: Chemical. 330:129265-129265. 2021
- Surrogate Humane Endpoints in Small Animal Models of Acute Lung Injury: A Modified Delphi Consensus Study of Researchers and Laboratory Animal Veterinarians*. Critical Care Medicine. 49:311-323. 2021
- Characterization of ADAMTS13 and von Willebrand factor levels in septic and non-septic ICU patients. PLoS ONE. 16:e0247017-e0247017. 2021
- Chlorhexidine locking device for central line infection prevention in ICU patients: protocol for an open-label pilot and feasibility randomized controlled trial. Pilot and Feasibility Studies. 6:26. 2020
- Hypercoagulability and coronavirus disease 2019–associated hypoxemic respiratory failure: Mechanisms and emerging management paradigms. Journal of Trauma and Acute Care Surgery. 89:e177-e181. 2020
- Neuromuscular blockade in patients with ARDS: a rapid practice guideline. Intensive Care Medicine. 46:1977-1986. 2020
- Identification of hemostatic markers that define the pre‐DIC state: A multi‐center observational study. Journal of Thrombosis and Haemostasis. 18:2524-2531. 2020
- Social determinants of health associated with the development of sepsis in adults: a scoping review protocol. BMJ Open. 10:e039146-e039146. 2020
- Diagnosis of ventilator-associated pneumonia in critically ill adult patients—a systematic review and meta-analysis. Intensive Care Medicine. 46:1170-1179. 2020
- Improving gender equity in critical care medicine: a protocol to establish priorities and strategies for implementation. BMJ Open. 10:e037090-e037090. 2020
- Data initiatives supporting critical care research and quality improvement in Canada: an environmental scan and narrative review. Canadian Journal of Anaesthesia. 67:475-484. 2020
- Fast I(n)dentification of Pathogens in Neonates (FINDPATH-N): protocol for a prospective pilot cohort study of next-generation sequencing for pathogen identification in neonates with suspected sepsis. BMJ Paediatrics Open. 4:e000651-e000651. 2020
- Electroplating of Multiple Materials in Parallel Using Patterned Gels with Applications in Electrochemical Sensing. Sensors. 20:886-886. 2020
- Epigenetic Profiling in Severe Sepsis: A Pilot Study of DNA Methylation Profiles in Critical Illness*. Critical Care Medicine. 48:142-150. 2020
- A national cross-sectional survey of public perceptions of the COVID-19 pandemic: Self-reported beliefs, knowledge, and behaviors. PLoS ONE. 15:e0241259-e0241259. 2020
- Comparison of the source and prognostic utility of cfDNA in trauma and sepsis. Intensive Care Medicine Experimental. 7:29. 2019
- Correction to: Project management lessons learned from the multicentre CYCLE pilot randomized controlled trial. Trials. 20:606. 2019
- Prognostic accuracy of the Hamilton Early Warning Score (HEWS) and the National Early Warning Score 2 (NEWS2) among hospitalized patients assessed by a rapid response team. Critical Care. 23:60. 2019
- Project management lessons learned from the multicentre CYCLE pilot randomized controlled trial. Trials. 20:532. 2019
- Tranexamic acid in cardiac surgery: a systematic review and meta-analysis (protocol). BMJ Open. 9:e028585-e028585. 2019
- Mortality Risk Profiles for Sepsis: A Novel Longitudinal and Multivariable Approach. Critical Care Explorations. 1:e0032-e0032. 2019
- Development of a point of care system for automated coma prognosis: a prospective cohort study protocol. BMJ Open. 9:e029621-e029621. 2019
- Gender differences in career satisfaction, moral distress, and incivility: a national, cross-sectional survey of Canadian critical care physicians. Canadian Journal of Anaesthesia. 66:503-511. 2019
- Attitudes of emergency department physicians and nurses toward implementation of an early warning score to identify critically ill patients: qualitative explanations for failed implementation. Canadian Journal of Emergency Medicine. 21:269-273. 2019
- Multicentre pilot randomised clinical trial of early in-bed cycle ergometry with ventilated patients. BMJ Open Respiratory Research. 6:e000383-e000383. 2019
- Rapid and inexpensive method for fabrication of multi-material multi-layer microfluidic devices. Journal of Micromechanics and Microengineering. 29:015013-015013. 2019
- Body temperature and mouse scoring systems as surrogate markers of death in cecal ligation and puncture sepsis. Intensive Care Medicine Experimental. 6:20. 2018
- Evaluating the effect of delayed activation of rapid response teams on patient outcomes: a systematic review protocol. Systematic Reviews. 7:42. 2018
- Physiotherapy in the neurotrauma intensive care unit: A scoping review. Journal of Critical Care. 48:390-406. 2018
- Sialidase down-regulation reduces non-HDL cholesterol, inhibits leukocyte transmigration, and attenuates atherosclerosis in ApoE knockout mice. Journal of Biological Chemistry. 293:14689-14706. 2018
- FLUID trial: a protocol for a hospital-wide open-label cluster crossover pragmatic comparative effectiveness randomised pilot trial. BMJ Open. 8:e022780-e022780. 2018
- Low-density lipoprotein (LDL)-dependent uptake of Gram-positive lipoteichoic acid and Gram-negative lipopolysaccharide occurs through LDL receptor. Scientific Reports. 8:10496. 2018
- Antimicrobial Efficacy of a New Chlorhexidine-based Device Against Staphylococcus aureus Colonization of Venous Catheters. Journal of Infusion Nursing. 41:103-112. 2018
- Examining the utility of the Hamilton early warning scores (HEWS) at triage: Retrospective pilot study in a Canadian emergency department. Canadian Journal of Emergency Medicine. 20:266-274. 2018
- Allogeneic Mesenchymal Stem Cells for Treatment of AKI after Cardiac Surgery. Journal of the American Society of Nephrology. 29:260-267. 2018
- A modified Delphi process to identify clinical and research priorities in patient and family centred critical care. Journal of Critical Care. 42:243-247. 2017
- Resuscitation fluid composition affects hepatic inflammation in a murine model of early sepsis. Intensive Care Medicine Experimental. 5:5. 2017
- Gender Parity in Critical Care Medicine. American Journal of Respiratory and Critical Care Medicine. 196:425-429. 2017
- DJ-1/PARK7 Impairs Bacterial Clearance in Sepsis. American Journal of Respiratory and Critical Care Medicine. 195:889-905. 2017
- A trial to determine whether septic shock-reversal is quicker in pediatric patients randomized to an early goal-directed fluid-sparing strategy versus usual care (SQUEEZE): study protocol for a pilot randomized controlled trial. Trials. 17:556. 2016
- Differential Expression of PCSK9 Modulates Infection, Inflammation, and Coagulation in a Murine Model of Sepsis. Shock. 46:672-680. 2016
- Extracellular Histones Increase Tissue Factor Activity and Enhance Thrombin Generation by Human Blood Monocytes. Shock. 46:655-662. 2016
- Syndecan-1 (CD138) deficiency increases Staphylococcus aureus infection but has no effect on pathology in a mouse model of peritoneal dialysis. Journal of Biomedical Science. 23:20. 2016
- The Intensive care unit specialist: Report from the Task Force of World Federation of Societies of Intensive and Critical Care Medicine. Journal of Critical Care. 35:223-228. 2016
- Multicountry survey of emergency and critical care medicine physicians’ fluid resuscitation practices for adult patients with early septic shock. BMJ Open. 6:e010041-e010041. 2016
- Higher versus lower blood pressure targets for vasopressor therapy in shock: a multicentre pilot randomized controlled trial. Intensive Care Medicine. 42:542-550. 2016
- Phosphatidylserine externalization and procoagulant activation of erythrocytes induced by Pseudomonas aeruginosa virulence factor pyocyanin. Journal of Cellular and Molecular Medicine. 20:710-720. 2016
- Interprofessional sepsis education module: a pilot study. Canadian Journal of Emergency Medicine. 18:143-145. 2016
- The impact of the Rasouli decision: a Survey of Canadian intensivists. Journal of Medical Ethics. 42:180-185. 2016
- Modified Early Warning Score (MEWS) Identifies Critical Illness among Ward Patients in a Resource Restricted Setting in Kampala, Uganda: A Prospective Observational Study. PLoS ONE. 11:e0151408-e0151408. 2016
- Peritoneal Dialysis Catheter Increases Leukocyte Recruitment in the Mouse Parietal Peritoneum Microcirculation and Causes Fibrosis. Advances in peritoneal dialysis. Conference on Peritoneal Dialysis. 36:7-15. 2016
- Cell-Free DNA Modulates Clot Structure and Impairs Fibrinolysis in Sepsis. Arteriosclerosis, Thrombosis and Vascular Biology. 35:2544-2553. 2015
- The offering of family presence during resuscitation: a systematic review and meta-analysis. Journal of Intensive Care. 3:41. 2015
- A microfluidic device for rapid quantification of cell-free DNA in patients with severe sepsis. Lab on a Chip. 15:3925-3933. 2015
- Postintubation hypotension in intensive care unit patients: A multicenter cohort study. Journal of Critical Care. 30:1055-1060. 2015
- A protocol for developing early warning score models from vital signs data in hospitals using ensembles of decision trees. BMJ Open. 5:e008699-e008699. 2015
- Fluid type and the use of renal replacement therapy in sepsis: a systematic review and network meta-analysis. Intensive Care Medicine. 41:1561-1571. 2015
- Delayed but not Early Treatment with DNase Reduces Organ Damage and Improves Outcome in a Murine Model of Sepsis. Shock. 44:166-172. 2015
- Blood Pressure Targets For Vasopressor Therapy. Shock. 43:530-539. 2015
- The Efficacy and Safety of Heparin in Patients With Sepsis. Critical Care Medicine. 43:511-518. 2015
- Intraaortic balloon pump in patients with cardiogenic shock complicating myocardial infarction. A systematic review and meta-analysis of randomized trials. Polskie Archiwum Medycyny Wewnetrznej. 125:181-190. 2015
- Nonbeneficial Treatment Canada. Critical Care Medicine. 43:270-281. 2015
- Family Presence during Resuscitation: A Canadian Critical Care Society Position Paper. Canadian Respiratory Journal. 22:201-205. 2015
- Intra-aortic balloon pump in patients with cardiogenic shock complicating myocardial infarction: a systematic review and meta-analysis of randomized trials (protocol). Systematic Reviews. 3:24. 2014
- Fluid Resuscitation in Sepsis. ACP journal club. 161:347-347. 2014
- Alpha‐1 Acid Glycoprotein Reduces Hepatic Leukocyte Recruitment in Murine Models of Either Early Endotoxemia or Early Sepsis. Microcirculation. 21:74-83. 2014
- Continuous Venovenous Hemofiltration versus Continuous Venovenous Hemodiafiltration in Critically Ill Patients: A Retrospective Cohort Study from a Canadian Tertiary Centre. Canadian Respiratory Journal. 21:176-180. 2014
- Development of a Murine Model of Early Sepsis in Diet-Induced Obesity. BioMed Research International. 2014:1-11. 2014
- Syndecan-1 in the Mouse Parietal Peritoneum Microcirculation in Inflammation. PLoS ONE. 9:e104537-e104537. 2014
- The Effect of Rapid Response Teams on End‐of‐Life Care: A Retrospective Chart Review. Canadian Respiratory Journal. 21:302-306. 2014
- Fluid resuscitation in severe sepsis and septic shock: systematic description of fluids used in randomized trials. Polskie Archiwum Medycyny Wewnetrznej. 123:603-608. 2013
- Lactobacillus for preventing recurrent urinary tract infections in women: meta-analysis.. Canadian Journal of Urology. 20:6607-6614. 2013
- Small bowel feeding and risk of pneumonia in adult critically ill patients: a systematic review and meta-analysis of randomized trials. Critical Care. 17:R127-R127. 2013
- The PRECISE RCT: Evolution of an Early Septic Shock Fluid Resuscitation Trial. Transfusion Medicine Reviews. 26:333-341. 2012
- Fluid Resuscitation with 5% albumin versus Normal Saline in Early Septic Shock: A pilot randomized, controlled trial. Journal of Critical Care. 27:317.e1-317.e6. 2012
- In VivoClearance of Alpha-1 Acid Glycoprotein Is Influenced by the Extent of Its N-Linked Glycosylation and by Its Interaction with the Vessel Wall. BioMed Research International. 2012:1-11. 2012
- Prognostic utility and characterization of cell-free DNA in patients with severe sepsis. Critical Care. 16:R151-R151. 2012
- Intravital Microscopy of the Murine Urinary Bladder Microcirculation. Microcirculation. 18:613-622. 2011
- Angiopoietin-1 and angiopoietin-2 as clinically informative prognostic biomarkers of morbidity and mortality in severe sepsis*. Critical Care Medicine. 39:702-710. 2011
- Comparison of Methods for the Purification of Alpha‐1 Acid Glycoprotein from Human Plasma. BioMed Research International. 2011:578207. 2011
- Innate immunity of the liver microcirculation. Cell and Tissue Research. 343:85-96. 2011
- Systematic review of reviews including animal studies addressing therapeutic interventions for sepsis*. Critical Care Medicine. 38:2401-2408. 2010
- A point mutation in the neu1 promoter recruits an ectopic repressor, Nkx3.2 and results in a mouse model of sialidase deficiency. Molecular Genetics and Metabolism. 97:43-52. 2009
- NITRIC OXIDE DONORS IN SEPSIS. Shock. 30:653-659. 2008
- Activated Protein C Up-Regulates IL-10 and Inhibits Tissue Factor in Blood Monocytes. Journal of Immunology. 181:2165-2173. 2008
- Ron receptor tyrosine kinase-dependent hepatic neutrophil recruitment and survival benefit in a murine model of bacterial peritonitis. Critical Care Medicine. 36:1585-1593. 2008
- Education and simulation techniques for improving reliability of care. Current Opinion in Critical Care. 13:737-741. 2007
- Hepatic leukocyte recruitment in response to time-limited expression of TNF-α and IL-1β. American Journal of Physiology - Gastrointestinal and Liver Physiology. 293:G663-G672. 2007
- Lung Development and Susceptibility to Ventilator-induced Lung Injury. American Journal of Respiratory and Critical Care Medicine. 171:743-752. 2005
- Pentastarch in a Balanced Solution Reduces Hepatic Leukocyte Recruitment in Early Sepsis. Microcirculation. 11:679-687. 2004
- Drug evaluation: E-5564.. IDrugs: the Investigational Drugs Journal. 7:582-590. 2004
- Hepatic leukocyte recruitment in a model of acute colitis. American Journal of Physiology - Gastrointestinal and Liver Physiology. 283:G561-G566. 2002
- Tifacogin (Chiron Corp/Pharmacia Corp).. IDrugs: the Investigational Drugs Journal. 5:91-97. 2002
- Oestradiol decreases rat apolipoprotein AI transcription via promoter site B. Journal of Molecular Endocrinology. 25:207-219. 2000
- Molecular mechanisms of tumor necrosis factorα–stimulated leukocyte recruitment into the murine hepatic circulation. Hepatology. 31:1123-1127. 2000
- Inhaled NO as a viable antiadhesive therapy for ischemia/reperfusion injury of distal microvascular beds.. Journal of Clinical Investigation. 101:2497-2505. 1998
- Nitric Oxide and Control of Endothelial Cell-Leukocyte Interactions. Sepsis. 1:115-122. 1998
- Relationship Between Transcription Factors and S14 Gene Expression in Response to Thyroid Hormone and Age. Experimental Biology and Medicine. 207:97-101. 1994
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preprints