Journal article
Topical Versus Intravenous Tranexamic Acid in Patients Undergoing Cardiac Surgery: The DEPOSITION Randomized Controlled Trial
Abstract
BACKGROUND: Although intravenous tranexamic acid is used in cardiac surgery to reduce bleeding and transfusion, topical tranexamic acid results in lower plasma concentrations compared with intravenous tranexamic acid, which may lower the risk of seizures. We aimed to determine whether topical tranexamic acid reduces the risk of in-hospital seizure without increasing the risk of transfusion among cardiac surgery patients.
METHODS: We conducted a …
Authors
Lamy A; Sirota DA; Jacques F; Poostizadeh A; Noiseux N; Efremov S; Demers P; Akselrod B; Wang CY; Arora RC
Journal
Circulation, Vol. 150, No. 17, pp. 1315–1323
Publisher
Wolters Kluwer
Publication Date
October 22, 2024
DOI
10.1161/circulationaha.124.069606
ISSN
0009-7322