Journal article
Surrogate Humane Endpoints in Small Animal Models of Acute Lung Injury: A Modified Delphi Consensus Study of Researchers and Laboratory Animal Veterinarians.
Abstract
OBJECTIVES: In many jurisdictions, ethical concerns require surrogate humane endpoints to replace death in small animal models of acute lung injury. Heterogenous selection and reporting of surrogate endpoints render interpretation and generalizability of findings between studies difficult. We aimed to establish expert-guided consensus among preclinical scientists and laboratory animal veterinarians on selection and reporting of surrogate …
Authors
McGinn R; Fergusson DA; Stewart DJ; Kristof AS; Barron CC; Thebaud B; McIntyre L; Stacey D; Liepmann M; Dodelet-Devillers A
Journal
Critical Care Medicine, Vol. 49, No. 2, pp. 311–323
Publisher
Wolters Kluwer
Publication Date
February 2021
DOI
10.1097/ccm.0000000000004734
ISSN
0090-3493