Pyridones Concept

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• Peroxiredoxin 1 inhibits the oxidative stress induced apoptosis in renal tubulointerstitial fibrosis  Journal Articles
• A Survey of the Use of Empiric Novel Anticoagulants During Investigation of Stroke  Journal Articles
• A biomarker-based risk score to predict death in patients with atrial fibrillation: the ABC (age, biomarkers, clinical history) death risk score  Journal Articles
• A randomized phase II trial of apixaban for the prevention of thromboembolism in patients with metastatic cancer  Journal Articles
• Accuracy of a Rapid Diagnostic Test for the Presence of Direct Oral Factor Xa or Thrombin Inhibitors in Urine—A Multicenter Trial  Journal Articles
• Acute management of bleeding in patients on novel oral anticoagulants  Journal Articles
• Adherence to apixaban for extended thromboprophylaxis after major abdominal or pelvic surgery for cancer: A prospective cohort study  Journal Articles
• Advantages and limitations of the new anticoagulants  Journal Articles
• An Open-label, Phase II Study of the Safety and Tolerability of Pirfenidone in Patients with Scleroderma-associated Interstitial Lung Disease: the LOTUSS Trial  Journal Articles
• An assay to measure levels of factor Xa inhibitors in blood and plasma  Journal Articles
• Andexanet Alfa for Acute Major Bleeding Associated with Factor Xa Inhibitors  Journal Articles
• Andexanet Alfa for the Reversal of Factor Xa Inhibitor Activity  Journal Articles
• Andexanet alfa versus four-factor prothrombin complex concentrate for the reversal of apixaban- or rivaroxaban-associated intracranial hemorrhage: a propensity score-overlap weighted analysis  Journal Articles
• Angiotensin-converting enzyme 2 (ACE2) levels in relation to risk factors for COVID-19 in two large cohorts of patients with atrial fibrillation  Journal Articles
• Another piece in the pirfenidone puzzle  Journal Articles
• Antacid Therapy and Disease Progression in Patients with Idiopathic Pulmonary Fibrosis Who Received Pirfenidone  Journal Articles
• Antacid therapy and disease outcomes in idiopathic pulmonary fibrosis: a pooled analysis  Journal Articles
• Anticoagulation for Mechanical Heart Valves  Journal Articles
• Apixaban Compared With Warfarin in Patients With Atrial Fibrillation and End-Stage Renal Disease: Lessons Learned  Journal Articles
• Apixaban for Extended Treatment of Venous Thromboembolism  Journal Articles
• Apixaban for Stroke Prevention in Atrial Fibrillation: Why are Event Rates Higher in Clinical Practice than in Randomized Trials?—A Systematic Review  Journal Articles
• Apixaban for Stroke Prevention in Subclinical Atrial Fibrillation  Journal Articles
• Apixaban in Acute Coronary Syndromes  Journal Articles
• Apixaban in Patients with Atrial Fibrillation  Journal Articles
• Apixaban to Prevent Recurrence After Cryptogenic Stroke in Patients With Atrial Cardiopathy  Journal Articles
• Apixaban to Prevent Venous Thromboembolism in Patients with Cancer  Journal Articles
• Apixaban versus Enoxaparin for Thromboprophylaxis after Hip Replacement  Journal Articles
• Apixaban versus Enoxaparin for Thromboprophylaxis in Medically Ill Patients  Journal Articles
• Apixaban versus Enoxaparin in Medically Ill Patients  Journal Articles
• Apixaban versus aspirin in patients with atrial fibrillation and previous stroke or transient ischaemic attack: a predefined subgroup analysis from AVERROES, a randomised trial  Journal Articles
• Apixaban versus enoxaparin for thromboprophylaxis after knee replacement (ADVANCE-2): a randomised double-blind trial  Journal Articles
• Apixaban vs Aspirin According to CHA2DS2-VASc Score in Subclinical Atrial Fibrillation  Journal Articles
• Apixaban, an Oral, Direct, Selective Factor Xa Inhibitor, in Combination With Antiplatelet Therapy After Acute Coronary Syndrome  Journal Articles
• Approach to the new oral anticoagulants in family practice: part 1: comparing the options.  Journal Articles
• Approach to the new oral anticoagulants in family practice: part 2: addressing frequently asked questions.  Journal Articles
• Appropriate Apixaban Dosing  Journal Articles
• Association of direct oral anticoagulant-proton pump inhibitor cotherapy with adverse outcomes: protocol for a population-based cohort study  Journal Articles
• Association of type of oral anticoagulation with risk of bleeding in 45,114 patients with venous thromboembolism during initial and extended treatment—A nationwide register‐based study  Journal Articles
• BIOSYNTHESIS OF MIMOSINE: INCORPORATION OF ASPARTIC ACID INTO THE PYRIDONE NUCLEUS  Journal Articles
• Beyond Unfractionated Heparin and Warfarin  Journal Articles
• Bilateral paramedian pontine infarcts: a rare cause of bilateral horizontal gaze palsy  Journal Articles
• Bleeding During Treatment With Aspirin Versus Apixaban in Patients With Atrial Fibrillation Unsuitable for Warfarin  Journal Articles
• Bleeding Outcomes in Patients Treated With Asundexian in Phase II Trials  Journal Articles
• Bleeding and antidotes in new oral anticoagulants  Journal Articles
• Bleeding with Direct Oral Anticoagulants vs Warfarin: Clinical Experience  Journal Articles
• Bleeding with direct oral anticoagulants vs warfarin: clinical experience  Journal Articles
• Broadening the Categories of Patients Eligible for Extended Venous Thromboembolism Treatment  Journal Articles
• Characteristics and Outcomes in Patients with Venous Thromboembolism Taking Concomitant Anti-Platelet Agents and Anticoagulants in the AMPLIFY Trial  Journal Articles
• Choosing wisely: The impact of patient selection on efficacy and safety outcomes in the EINSTEIN-DVT/PE and AMPLIFY trials  Journal Articles
• Clinical Experience With the New Oral Anticoagulants for Treatment of Venous Thromboembolism  Journal Articles
• Clinical Implications of Reversal Agents for Direct Oral Anticoagulants  Journal Articles
• Clinical presentation and course of bleeding events in patients with venous thromboembolism, treated with apixaban or enoxaparin and warfarin  Journal Articles
• Clinical review: Clinical management of new oral anticoagulants: a structured review with emphasis on the reversal of bleeding complications  Journal Articles
• Coagulation assays and direct oral anticoagulant levels among patients having an elective surgery or procedure  Journal Articles
• Comparative Pharmacodynamics and Pharmacokinetics of Oral Direct Thrombin and Factor Xa Inhibitors in Development  Journal Articles
• Comparative effectiveness and safety of direct acting oral anticoagulants in nonvalvular atrial fibrillation for stroke prevention: a systematic review and meta-analysis  Journal Articles
• Comparative effectiveness and safety of direct oral anticoagulants versus vitamin K antagonists in nonvalvular atrial fibrillation: a Canadian multicentre observational cohort study  Journal Articles
• Comparative effectiveness and safety of the novel oral anticoagulants: do the pivotal clinical trials point to a new paradigm?  Journal Articles
• Comparative efficacy and safety of first-line antiretroviral therapy for the treatment of HIV infection: a systematic review and network meta-analysis  Journal Articles
• Comparison of the effects of apixaban and rivaroxaban on prothrombin and activated partial thromboplastin times using various reagents  Journal Articles
• Continued vs. interrupted direct oral anticoagulants at the time of device surgery, in patients with moderate to high risk of arterial thrombo-embolic events (BRUISE CONTROL-2)  Journal Articles
• Deferiprone and hepatic fibrosis  Journal Articles
• Deferiprone in Friedreich ataxia: A 6‐Month randomized controlled trial  Journal Articles
• Deferiprone-related arthropathy of the knee in a thalassemic patient: report of a case and review of the literature  Journal Articles
• Derivation and validation of predictors of oral anticoagulant-related adverse events in seniors transitioning from hospital to home  Journal Articles
• Direct AMPK Activation Corrects NASH in Rodents Through Metabolic Effects and Direct Action on Inflammation and Fibrogenesis  Journal Articles
• Direct comparative effectiveness and safety between non-vitamin K antagonist oral anticoagulants for stroke prevention in nonvalvular atrial fibrillation: a systematic review and meta-analysis of observational studies  Journal Articles
• Direct oral anticoagulants compared with vitamin K antagonists for acute venous thromboembolism: evidence from phase 3 trials  Journal Articles
• Direct oral anticoagulants compared with vitamin K antagonists for acute venous thromboembolism: evidence from phase 3 trials.  Journal Articles
• Direct oral anticoagulants: evidence and unresolved issues  Journal Articles
• Does prescribing apixaban or rivaroxaban versus warfarin for patients diagnosed with atrial fibrillation save health system costs? A multivalued treatment effects analysis  Journal Articles
• Doravirine versus ritonavir-boosted darunavir in antiretroviral-naive adults with HIV-1 (DRIVE-FORWARD): 48-week results of a randomised, double-blind, phase 3, non-inferiority trial  Journal Articles
• Doravirine versus ritonavir-boosted darunavir in antiretroviral-naive adults with HIV-1 (DRIVE-FORWARD): 96-week results of a randomised, double-blind, non-inferiority, phase 3 trial  Journal Articles
• Early time courses of recurrent thromboembolism and bleeding during apixaban or enoxaparin/warfarin therapy  Journal Articles
• Effect of Osocimab in Preventing Venous Thromboembolism Among Patients Undergoing Knee Arthroplasty  Journal Articles
• Effect of apixaban on brain infarction and microbleeds: AVERROES-MRI assessment study  Journal Articles
• Effect of continued antifibrotic therapy after forced vital capacity decline in patients with idiopathic pulmonary fibrosis; a real world multicenter cohort study  Journal Articles
• Effect of extended‐duration thromboprophylaxis on venous thromboembolism and major bleeding among acutely ill hospitalized medical patients: a bivariate analysis  Journal Articles
• Effect of statins on disease-related outcomes in patients with idiopathic pulmonary fibrosis  Journal Articles
• Effectiveness and safety among direct oral anticoagulants in nonvalvular atrial fibrillation: A multi‐database cohort study with meta‐analysis  Journal Articles
• Efficacy and safety of apixaban compared with aspirin in patients who previously tried but failed treatment with vitamin K antagonists: results from the AVERROES trial  Journal Articles
• Efficacy and safety of apixaban compared with aspirin in the elderly: a subgroup analysis from the AVERROES trial  Journal Articles
• Eligibility criteria from pharmaceutical randomised controlled trials of idiopathic pulmonary fibrosis: a registry-based study  Journal Articles
• Evaluation of the Age, Biomarkers, and Clinical History–Bleeding Risk Score in Patients With Atrial Fibrillation With Combined Aspirin and Anticoagulation Therapy Enrolled in the ARISTOTLE and RE-LY Trials  Journal Articles
• Evolving use of new oral anticoagulants for treatment of venous thromboembolism  Journal Articles
• Extended treatment of venous thromboembolism.  Journal Articles
• Factor Xa and thrombin as targets for new oral anticoagulants  Journal Articles
• Fluorofenidone Offers Improved Renoprotection at Early Interventions during the Course of Diabetic Nephropathy in db/db Mice via Multiple Pathways  Journal Articles
• Gastrointestinal bleeding with the new oral anticoagulants – defining the issues and the management strategies  Journal Articles
• Hemostatic Efficacy and Anti-FXa (Factor Xa) Reversal With Andexanet Alfa in Intracranial Hemorrhage: ANNEXA-4 Substudy  Journal Articles
• How I treat target-specific oral anticoagulant–associated bleeding  Journal Articles
• In AF, apixaban reduced stroke or systemic embolism compared with warfarin, regardless of patient age  Journal Articles
• Incorporating edoxaban into the choice of anticoagulants for atrial fibrillation  Journal Articles
• International Council for Standardization in Haematology (ICSH) Recommendations for Laboratory Measurement of Direct Oral Anticoagulants  Journal Articles
• Is there a role for the novel oral anticoagulants in patients with an acute coronary syndrome? A review of the clinical trials  Journal Articles
• KEYNOTE-022: Pembrolizumab with trametinib in patients with BRAF wild-type melanoma or advanced solid tumours irrespective of BRAF mutation  Journal Articles
• Laboratory Measurement of the Anticoagulant Activity of the Non–Vitamin K Oral Anticoagulants  Journal Articles
• Laboratory Monitoring of Non–Vitamin K Antagonist Oral Anticoagulant Use in Patients With Atrial Fibrillation  Journal Articles
• Laboratory measurement of the direct oral anticoagulants  Journal Articles
• Lack of progressive hepatic fibrosis during long-term therapy with deferiprone in subjects with transfusion-dependent beta-thalassemia  Journal Articles
• Long-Term Treatment with Apixaban in Patients with Atrial Fibrillation: Outcomes during the Open-Label Extension following AVERROES  Journal Articles
• Low molecular weight heparin anti-Xa assays can identify patients with clinically important apixaban and rivaroxaban drug levels  Journal Articles
• Macitentan reduces progression of TGF-β1-induced pulmonary fibrosis and pulmonary hypertension  Journal Articles
• Management of rivaroxaban- or apixaban-associated major bleeding with prothrombin complex concentrates: a cohort study  Journal Articles
• Managing New Oral Anticoagulants in the Perioperative and Intensive Care Unit Setting  Journal Articles
• Milvexian vs apixaban for stroke prevention in atrial fibrillation: The LIBREXIA atrial fibrillation trial rationale and design.  Journal Articles
• Modification of Outcomes With Aspirin or Apixaban in Relation to CHADS ₂ and CHA ₂ DS ₂ -VASc Scores in Patients With Atrial Fibrillation  Journal Articles
• Modification of Outcomes With Aspirin or Apixaban in Relation to Female and Male Sex in Patients With Atrial Fibrillation  Journal Articles
• NOAC monitoring, reversal agents, and post-approval safety and effectiveness evaluation: A cardiac safety research consortium think tank  Journal Articles
• Network meta-analysis of therapies for previously untreated advanced BRAF-mutated melanoma  Journal Articles
• New Anticoagulants for Atrial Fibrillation  Journal Articles
• New Anticoagulants for Treatment of Venous Thromboembolism  Journal Articles
• New Anticoagulants for the Prevention of Thromboembolism  Journal Articles
• New Antithrombotic Drugs: Potential for Use in Oncology  Journal Articles
• New anticoagulants in atrial fibrillation management  Conferences
• New oral anticoagulant agents – general features and outcomes in subsets of patients  Journal Articles
• New oral anticoagulants and oculoplastic surgery  Journal Articles
• New oral anticoagulants for stroke prevention in atrial fibrillation: impact of study design, double counting and unexpected findings on interpretation of study results and conclusions  Journal Articles
• New oral anticoagulants in elderly patients  Journal Articles
• New oral anticoagulants: not quite there yet  Journal Articles
• Novel Oral Anticoagulants: A Focused Review for Stroke Physicians  Journal Articles
• Novel Oral Factor Xa and Thrombin Inhibitors in the Management of Thromboembolism  Journal Articles
• Novel oral anticoagulants in gastroenterology practice  Journal Articles
• Novel oral anticoagulants in secondary prevention of stroke  Journal Articles
• Optimal Prescription of the Lower Dose of Apixaban  Journal Articles
• Optimizing the safety of treatment for venous thromboembolism in the era of the direct oral anticoagulants  Journal Articles
• Oral Apixaban for the Treatment of Acute Venous Thromboembolism  Journal Articles
• Oral Direct Factor Xa Inhibitors  Journal Articles
• Oral anticoagulants in coronary heart disease (Section IV) Position paper of the ESC Working Group on Thrombosis – Task Force on Anticoagulants in Heart Disease  Journal Articles
• Oral anticoagulation in patients with cancer who have no therapeutic or prophylactic indication for anticoagulation  Journal Articles
• Oral anticoagulation in people with cancer who have no therapeutic or prophylactic indication for anticoagulation  Journal Articles
• Oral anticoagulation in people with cancer who have no therapeutic or prophylactic indication for anticoagulation  Journal Articles
• Oral apixaban for the treatment of venous thromboembolism in cancer patients: results from the AMPLIFY trial  Journal Articles
• Overview of the New Oral Anticoagulants  Journal Articles
• PTEN status is a crucial determinant of the functional outcome of combined MEK and mTOR inhibition in cancer  Journal Articles
• Perioperative management of apixaban in patients with advanced CKD undergoing a planned invasive procedure  Journal Articles
• Perioperative management of patients who are receiving a novel oral anticoagulant  Journal Articles
• Periprocedural Management of Oral Anticoagulation  Journal Articles
• Periprocedural antithrombotic and bridging therapy: recommendations for standardized reporting in patients with arterial indications for chronic oral anticoagulant therapy  Journal Articles
• Pharmacokinetics of apixaban and tacrolimus or cyclosporine in kidney and lung transplant recipients  Journal Articles
• Pharmacologic Properties of the New Oral Anticoagulants: A Clinician-oriented Review with a Focus on Perioperative Management  Journal Articles
• Phase 2 clinical trial of PBI-4050 in patients with idiopathic pulmonary fibrosis  Journal Articles
• Phase I pharmacokinetic study of single agent trametinib in patients with advanced cancer and hepatic dysfunction  Journal Articles
• Plasma Apixaban Levels in Patients Treated Off Label With the Lower Dose  Journal Articles
• Potential net clinical benefit of population-wide implementation of apixaban and dabigatran among European patients with atrial fibrillation  Journal Articles
• Potential of new anticoagulants in patients with cancer  Journal Articles
• Practical aspects of new oral anticoagulant use in atrial fibrillation  Journal Articles
• Practical management of bleeding due to the anticoagulants dabigatran, rivaroxaban, and apixaban  Journal Articles
• Predictors of Bleeding in the Perioperative Anticoagulant Use for Surgery Evaluation Study  Journal Articles
• Prevalence of Emergent Dolutegravir Resistance Mutations in People Living with HIV: A Rapid Scoping Review  Journal Articles
• Profile of Patients Diagnosed With Acute Venous Thromboembolism in Routine Clinical Practice: The RE-COVERY DVT/PE™ Study  Journal Articles
• Progressive fibrosing interstitial lung disease: treatable traits and therapeutic strategies  Journal Articles
• Prothrombin Complex Concentrate for Major Bleeding on Factor Xa Inhibitors: A Prospective Cohort Study  Journal Articles
• Prothrombin complex concentrate for emergency surgery in patients on oral Xa-inhibitors  Journal Articles
• Randomized phase 2 trial comparing JNJ‐9375, a thrombin‐directed antibody, with apixaban for prevention of venous thrombosis  Journal Articles
• Rationale and design of AVERROES: Apixaban versus acetylsalicylic acid to prevent stroke in atrial fibrillation patients who have failed or are unsuitable for vitamin K antagonist treatment  Journal Articles
• Rationale and design of the Apixaban for the Reduction of Thrombo-Embolism in Patients With Device-Detected Sub-Clinical Atrial Fibrillation (ARTESiA) trial  Journal Articles
• Reducing the risk of recurrent stroke in patients with AF  Journal Articles
• Resident Physicians Choices of Anticoagulation for Stroke Prevention in Patients With Nonvalvular Atrial Fibrillation  Journal Articles
• Response to “Critical Analysis of Apixaban Dose Adjustment Criteria”  Journal Articles
• Response.  Journal Articles
• Reversal of Direct Oral Anticoagulants: Current Status and Future Directions  Journal Articles
• Review: In renal impairment, apixaban reduces, or does not increase, bleeding compared with other anticoagulants  Journal Articles
• Risk Stratification and Stroke Prevention Therapy Care Gaps in Canadian Atrial Fibrillation Patients (from the Co-ordinated National Network to Engage Physicians in the Care and Treatment of Patients With Atrial Fibrillation Chart Audit)  Journal Articles
• Risk of Cardiovascular Events and Mortality Among Elderly Patients With Reduced GFR Receiving Direct Oral Anticoagulants  Journal Articles
• Risk of Hospitalization With Hemorrhage Among Older Adults Taking Clarithromycin vs Azithromycin and Direct Oral Anticoagulants  Journal Articles
• Risk of intracranial hemorrhage between different direct oral anticoagulants in older patients seen in the emergency department with a head injury: A population-based cohort study  Journal Articles
• Rivaroxaban and apixaban are less effective than enoxaparin for the prevention of catheter-induced clotting in vitro  Journal Articles
• Rivaroxaban for the prevention and treatment of venous thromboembolism  Journal Articles
• Safety and efficacy of doravirine as first-line therapy in adults with HIV-1: week 192 results from the open-label extensions of the DRIVE-FORWARD and DRIVE-AHEAD phase 3 trials  Journal Articles
• Screening of Multiple Biomarkers Associated With Ischemic Stroke in Atrial Fibrillation  Journal Articles
• Selective cleavage of heparin using aqueous 2-hydroxypyridine: Production of an aldose-terminating fragment with high anticoagulant activity  Journal Articles
• Serial measurement of interleukin‐6 and risk of mortality in anticoagulated patients with atrial fibrillation: Insights from ARISTOTLE and RE‐LY trials  Journal Articles
• Severity of renal impairment in patients with heart failure and atrial fibrillation: implications for non‐vitamin K antagonist oral anticoagulant dose adjustment  Journal Articles
• Strategy of continued vs interrupted novel oral anticoagulant at time of device surgery in patients with moderate to high risk of arterial thromboembolic events: The BRUISE CONTROL-2 trial  Journal Articles
• Stroke Prevention in Subclinical Atrial Fibrillation  Journal Articles
• Stroke Risk and Efficacy of Apixaban in Atrial Fibrillation Patients with Moderate Chronic Kidney Disease  Journal Articles
• Stroke prevention in atrial fibrillation: Closing the gap  Journal Articles
• Systemic Therapy for Previously Untreated Advanced BRAF -Mutated Melanoma: Navigating a Shifting Landscape  Journal Articles
• The Design and Rationale of the Trail1 Trial: A Randomized Double-Blind Phase 2 Clinical Trial of Pirfenidone in Rheumatoid Arthritis-Associated Interstitial Lung Disease  Journal Articles
• The Non-Vitamin K Antagonist Oral Anticoagulants in Heart Disease: Section V—Special Situations  Journal Articles
• The Perioperative Anticoagulant Use for Surgery Evaluation (PAUSE) Study for Patients on a Direct Oral Anticoagulant Who Need an Elective Surgery or Procedure: Design and Rationale  Journal Articles
• The Risk of Acute Kidney Injury with Oral Anticoagulants in Elderly Adults with Atrial Fibrillation  Journal Articles
• The effects of apixaban on hospitalizations in patients with different types of atrial fibrillation: insights from the AVERROES trial  Journal Articles
• The novel biomarker-based ABC (age, biomarkers, clinical history)-bleeding risk score for patients with atrial fibrillation: a derivation and validation study  Journal Articles
• The top 4 advances in antithrombotic care in the last year  Journal Articles
• The use of skin Fe levels as a surrogate marker for organ Fe levels, to monitor treatment in cases of iron overload  Journal Articles
• Therapeutic targets in idiopathic pulmonary fibrosis  Journal Articles
• Transition from apixaban to warfarin—addressing excess stroke, systemic embolism, and major bleeding  Journal Articles
• Treatment of idiopathic pulmonary fibrosis with Nintedanib: an update  Journal Articles
• Treatment of idiopathic pulmonary fibrosis: a network meta-analysis  Journal Articles
• Trends in Prescribing Oral Anticoagulants in Canada, 2008–2014  Journal Articles
• Venous thromboembolism management: where do novel anticoagulants fit?  Journal Articles
• Warfarin faring better: vitamin K antagonists beat rivaroxaban and apixaban in the INVICTUS and PROACT Xa trials  Journal Articles
• Well-managed warfarin is superior to NOACs Response  Journal Articles