Journal article
Apixaban in Patients with Atrial Fibrillation
Abstract
BACKGROUND: Vitamin K antagonists have been shown to prevent stroke in patients with atrial fibrillation. However, many patients are not suitable candidates for or are unwilling to receive vitamin K antagonist therapy, and these patients have a high risk of stroke. Apixaban, a novel factor Xa inhibitor, may be an alternative treatment for such patients.
METHODS: In a double-blind study, we randomly assigned 5599 patients with atrial …
Authors
Connolly SJ; Eikelboom J; Joyner C; Diener H-C; Hart R; Golitsyn S; Flaker G; Avezum A; Hohnloser SH; Diaz R
Journal
New England Journal of Medicine, Vol. 364, No. 9, pp. 806–817
Publisher
Massachusetts Medical Society
Publication Date
March 3, 2011
DOI
10.1056/nejmoa1007432
ISSN
0028-4793