Direct oral anticoagulants compared with vitamin K antagonists for acute venous thromboembolism: evidence from phase 3 trials Journal Articles

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abstract

Key Points DOACs have similar efficacy as VKAs in the treatment of acute symptomatic VTE, but significantly reduce the risk of major bleeding. The efficacy and safety of DOACs in the treatment of acute VTE are consistent in clinically important subgroups.

authors

van Es, Nick
Coppens, Michiel
Schulman, Sam
Middeldorp, Saskia
Büller, Harry R

status

published

publication date

September 18, 2014

has subject area

1102 Cardiorespiratory Medicine and Haematology (FoR)
1103 Clinical Sciences (FoR)
1114 Paediatrics and Reproductive Medicine (FoR)
Acute Disease (MeSH)
Administration, Oral (MeSH)
Anticoagulants (MeSH)
Benzimidazoles (MeSH)
Clinical Trials, Phase III as Topic (MeSH)
Dabigatran (MeSH)
Factor Xa Inhibitors (MeSH)
Female (MeSH)
Hemorrhage (MeSH)
Humans (MeSH)
Immunology (Science Metrix)
Male (MeSH)
Morpholines (MeSH)
Pyrazoles (MeSH)
Pyridines (MeSH)
Pyridones (MeSH)
Randomized Controlled Trials as Topic (MeSH)
Rivaroxaban (MeSH)
Thiazoles (MeSH)
Thiophenes (MeSH)
Venous Thromboembolism (MeSH)
Vitamin K (MeSH)

published in

Blood Journal