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Laboratory Monitoring of Non–Vitamin K Antagonist...
Journal article

Laboratory Monitoring of Non–Vitamin K Antagonist Oral Anticoagulant Use in Patients With Atrial Fibrillation: A Review

Abstract

Importance: The non-vitamin K antagonist oral anticoagulants (NOACs) apixaban, dabigatran, edoxaban, and rivaroxaban are administered in fixed doses without anticoagulant monitoring. Randomized trials show that unmonitored NOAC therapy is at least as effective as and safer than dose-adjusted warfarin for stroke prevention in patients with nonvalvular atrial fibrillation. Subgroup analyses indicate that plasma drug levels or anticoagulant …

Authors

Eikelboom JW; Quinlan DJ; Hirsh J; Connolly SJ; Weitz JI

Journal

JAMA Cardiology, Vol. 2, No. 5, pp. 566–574

Publisher

American Medical Association (AMA)

Publication Date

May 1, 2017

DOI

10.1001/jamacardio.2017.0364

ISSN

2380-6583