Proto-Oncogene Proteins c-akt Concept

subject area of

• A CD133-AKT-Wnt signaling axis drives glioblastoma brain tumor-initiating cells  Journal Articles
• A phase II clinical and pharmacodynamic study of temsirolimus in advanced neuroendocrine carcinomas  Conferences
• A role of SIPL1/SHARPIN in promoting resistance to hormone therapy in breast cancer  Journal Articles
• Activating AKT1 and PIK3CA Mutations in Metastatic Castration-Resistant Prostate Cancer  Journal Articles
• Adiponectin resistance precedes the accumulation of skeletal muscle lipids and insulin resistance in high-fat-fed rats  Journal Articles
• Administration of dexamethasone protects mice against ischemia/reperfusion induced renal injury by suppressing PI3K/AKT signaling.  Journal Articles
• Akt Is Activated in Response to an Apoptotic Signal  Journal Articles
• Akt Mediates Mechanical Strain-Induced Collagen Production by Mesangial Cells  Journal Articles
• Akt isoform specific effects in ovarian cancer progression  Journal Articles
• Altered microRNA Transcriptome in Cultured Human Airway Cells upon Infection with SARS-CoV-2  Journal Articles
• An emerging role for Wnt and GSK3 signaling pathways in schizophrenia  Journal Articles
• Androgen Induces Adaptation to Oxidative Stress in Prostate Cancer: Implications for Treatment with Radiation Therapy  Journal Articles
• Antagonists of the serotonin receptor 5A target human breast tumor initiating cells  Journal Articles
• Anti-pneumococcal deficits of monocyte-derived macrophages from the advanced-age, frail elderly and related impairments in PI3K-AKT signaling  Journal Articles
• BRCA1 is a novel target to improve endothelial dysfunction and retard atherosclerosis  Journal Articles
• Brief intense interval exercise activates AMPK and p38 MAPK signaling and increases the expression of PGC-1α in human skeletal muscle  Journal Articles
• Carbohydrate Does Not Augment Exercise-Induced Protein Accretion versus Protein Alone  Journal Articles
• Caveolin-1 phosphorylation is required for stretch-induced EGFR and Akt activation in mesangial cells  Journal Articles
• Cell surface expression of 78-kDa glucose-regulated protein (GRP78) mediates diabetic nephropathy  Journal Articles
• Characterization of Mutational Status, Spheroid Formation, and Drug Response of a New Genomically-Stable Human Ovarian Clear Cell Carcinoma Cell Line, 105C  Journal Articles
• Characterization of sphere-propagating cells with stem-like properties from DU145 prostate cancer cells  Journal Articles
• Clear cell renal cell carcinoma induces fibroblast-mediated production of stromal periostin  Journal Articles
• Co-existence of high levels of the PTEN protein with enhanced Akt activation in renal cell carcinoma  Journal Articles
• Collagen I induction by high glucose levels is mediated by epidermal growth factor receptor and phosphoinositide 3-kinase/Akt signalling in mesangial cells  Journal Articles
• Contactin-1 Reduces E-Cadherin Expression Via Activating AKT in Lung Cancer  Journal Articles
• Differential localization and anabolic responsiveness of mTOR complexes in human skeletal muscle in response to feeding and exercise  Journal Articles
• Duplication of AKT3 as a cause of macrocephaly in duplication 1q43q44  Journal Articles
• EGFR-PLCγ1 signaling mediates high glucose-induced PKCβ1-Akt activation and collagen I upregulation in mesangial cells  Journal Articles
• Effects of PKB/Akt inhibitors on insulin-stimulated lipogenesis and phosphorylation state of lipogenic enzymes in white adipose tissue  Journal Articles
• Effects of dietary folic acid supplementation on lactation performance and mammary epithelial cell development of dairy cows and its regulatory mechanism  Journal Articles
• Endoplasmic Reticulum Chaperone GRP78 Protects Heart From Ischemia/Reperfusion Injury Through Akt Activation  Journal Articles
• Enhanced Amino Acid Sensitivity of Myofibrillar Protein Synthesis Persists for up to 24 h after Resistance Exercise in Young Men1–3  Journal Articles
• Epigenetic mechanisms of melatonin action in human SH-SY5Y neuroblastoma cells  Journal Articles
• Extracellular Vesicles from BMSCs Prevent Glucocorticoid-Induced BMECs Injury by Regulating Autophagy via the PI3K/Akt/mTOR Pathway.  Journal Articles
• Fish oil supplementation suppresses resistance exercise and feeding-induced increases in anabolic signaling without affecting myofibrillar protein synthesis in young men  Journal Articles
• Fluorofenidone Offers Improved Renoprotection at Early Interventions during the Course of Diabetic Nephropathy in db/db Mice via Multiple Pathways  Journal Articles
• GSK3 Deficiencies in Hematopoietic Stem Cells Initiate Pre-neoplastic State that Is Predictive of Clinical Outcomes of Human Acute Leukemia  Journal Articles
• Genome-wide germline correlates of the epigenetic landscape of prostate cancer  Journal Articles
• Guanosine Protects Glial Cells Against 6-Hydroxydopamine Toxicity  Journal Articles
• Guanosine protects SH-SY5Y cells against β-amyloid-induced apoptosis  Journal Articles
• HDL protects against doxorubicin-induced cardiotoxicity in a scavenger receptor class B type 1-, PI3K-, and Akt-dependent manner  Journal Articles
• High Density Lipoprotein Stimulated Migration of Macrophages Depends on the Scavenger Receptor Class B, Type I, PDZK1 and Akt1 and Is Blocked by Sphingosine 1 Phosphate Receptor Antagonists  Journal Articles
• High Glucose Up-regulates ADAM17 through HIF-1α in Mesangial Cells  Journal Articles
• High-density lipoprotein protects cardiomyocytes against necrosis induced by oxygen and glucose deprivation through SR-B1, PI3K, and AKT1 and 2  Journal Articles
• Hydrogen sulfide is a regulator of mammary gland development in prepubescent female mice  Journal Articles
• Hyperinsulinemia-induced vascular smooth muscle cell (VSMC) migration and proliferation is mediated by converging mechanisms of mitochondrial dysfunction and oxidative stress  Journal Articles
• IGF-1 Protects Intestinal Epithelial Cells From Oxidative Stress-Induced Apoptosis  Journal Articles
• IQGAP2, A candidate tumour suppressor of prostate tumorigenesis  Journal Articles
• Identification of MEK- and phosphoinositide 3-kinase-dependent signalling as essential events during Chlamydia pneumoniae invasion of HEp2 cells  Journal Articles
• Immobilization induces anabolic resistance in human myofibrillar protein synthesis with low and high dose amino acid infusion  Journal Articles
• Increased skeletal muscle glucose uptake by rosemary extract through AMPK activation  Journal Articles
• Insulin, Insulin-like Growth Factor-I, and Platelet-Derived Growth Factor Activate Extracellular Signal-Regulated Kinase by Distinct Pathways in Muscle Cells  Journal Articles
• Ionizing radiation regulates the expression of AMP-activated protein kinase (AMPK) in epithelial cancer cells  Journal Articles
• Liraglutide Protects Pancreatic Islet From Ischemic Injury by Reducing Oxidative Stress and Activating Akt Signaling During Cold Preservation to Improve Islet Transplantation Outcomes  Journal Articles
• Macrophages Regulate Unilateral Ureteral Obstruction-Induced Renal Lymphangiogenesis through C-C Motif Chemokine Receptor 2–Dependent Phosphatidylinositol 3-Kinase-AKT–Mechanistic Target of Rapamycin Signaling and Hypoxia-Inducible Factor-1α/Vascular Endothelial Growth Factor-C Expression  Journal Articles
• Maternal nutrient restriction impairs young adult offspring ovarian signaling resulting in reproductive dysfunction and follicle loss†  Journal Articles
• Mechanisms of exercise‐induced survival motor neuron expression in the skeletal muscle of spinal muscular atrophy‐like mice  Journal Articles
• Mitogen-activated protein kinases Erk1/2 and p38 are required for maximal regulation of TIMP-1 by oncostatin M in murine fibroblasts  Journal Articles
• Molecular responses to high-intensity interval exerciseThis paper is one of a selection of papers published in this Special Issue, entitled 14th International Biochemistry of Exercise Conference – Muscles as Molecular and Metabolic Machines, and has undergone the Journal’s usual peer review process.  Journal Articles
• Mosaic Activating Mutations in FGFR1 Cause Encephalocraniocutaneous Lipomatosis  Journal Articles
• Mutations of AKT3 are associated with a wide spectrum of developmental disorders including extreme megalencephaly  Journal Articles
• Negative Regulation of β4 Integrin Transcription by Homeodomain-Interacting Protein Kinase 2 and p53 Impairs Tumor Progression  Journal Articles
• Neural Cell Adhesion Protein CNTN1 Promotes the Metastatic Progression of Prostate Cancer  Journal Articles
• Oncostatin M induction of eotaxin-1 expression requires the convergence of PI3′K and ERK1/2 MAPK signal transduction pathways  Journal Articles
• Opposing Functions of Akt Isoforms in Lung Tumor Initiation and Progression  Journal Articles
• Out‐FOX(O)ing proteolysis in sepsis  Journal Articles
• PDZK1 in leukocytes protects against cellular apoptosis and necrotic core development in atherosclerotic plaques in high fat diet fed ldl receptor deficient mice  Journal Articles
• PGC‐1α gene expression is down‐regulated by Akt‐mediated phosphorylation and nuclear exclusion of FoxO1 in insulin‐stimulated skeletal muscle  Journal Articles
• PIKfyve: a new fish in the growing pool of AMPK substrates  Journal Articles
• PKC-β1 Mediates Glucose-Induced Akt Activation and TGF-β1 Upregulation in Mesangial Cells  Journal Articles
• PTEN inhibits BMI1 function independently of its phosphatase activity  Journal Articles
• PTEN status is a crucial determinant of the functional outcome of combined MEK and mTOR inhibition in cancer  Journal Articles
• Palmitate acutely induces insulin resistance in isolated muscle from obese but not lean humans  Journal Articles
• Panax quinquefolium saponin combined with dual antiplatelet drugs inhibits platelet adhesion to injured HUVECs via PI3K/AKT and COX pathways  Journal Articles
• Parathyroid hormone-related protein induces fibronectin up-regulation in rat mesangial cells through reactive oxygen species/Src/EGFR signaling  Journal Articles
• Peripheral Blood Gene Expression Changes during Allergen Inhalation Challenge in Atopic Asthmatic Individuals  Journal Articles
• Phosphorylation switches Bax from promoting to inhibiting apoptosis thereby increasing drug resistance  Journal Articles
• Propranolol Improves Impaired Hepatic Phosphatidylinositol 3-Kinase/Akt Signaling after Burn Injury  Journal Articles
• Prostaglandin E₂ inhibits profibrotic function of human pulmonary fibroblasts by disrupting Ca²⁺ signaling  Journal Articles
• Protein Ingestion Increases Myofibrillar Protein Synthesis after Concurrent Exercise  Journal Articles
• Rapid Repression of ADP Transport by Palmitoyl-CoA Is Attenuated by Exercise Training in Humans: A Potential Mechanism to Decrease Oxidative Stress and Improve Skeletal Muscle Insulin Signaling  Journal Articles
• Rapid aminoacidemia enhances myofibrillar protein synthesis and anabolic intramuscular signaling responses after resistance exercise  Journal Articles
• Regulation of IL-17A responses in human airway smooth muscle cells by Oncostatin M  Journal Articles
• Resistance exercise decreases eIF2Bε phosphorylation and potentiates the feeding-induced stimulation of p70^S6K1 and rpS6 in young men  Journal Articles
• Resveratrol enhances prostate cancer cell response to ionizing radiation. Modulation of the AMPK, Akt and mTOR pathways  Journal Articles
• SIPL1 enhances the proliferation, attachment, and migration of CHO cells by inhibiting PTEN function  Journal Articles
• SREBP-1 Mediates Angiotensin II-Induced TGF-β1 Upregulation and Glomerular Fibrosis  Journal Articles
• SREBP-1 activation by glucose mediates TGF-β upregulation in mesangial cells  Journal Articles
• Selective involvement of the PI3K/PKB/bad pathway in retinal cell death  Journal Articles
• Semaphorin 3F Antagonizes Neurotrophin-Induced Phosphatidylinositol 3-Kinase and Mitogen-Activated Protein Kinase Kinase Signaling: A Mechanism for Growth Cone Collapse  Journal Articles
• Specific attenuation of protein kinase phosphorylation in muscle with a high mitochondrial content  Journal Articles
• Sphingosine-1-Phosphate Receptor 1, Expressed in Myeloid Cells, Slows Diet-Induced Atherosclerosis and Protects against Macrophage Apoptosis in Ldlr KO Mice  Journal Articles
• Synergistic effects of pi3k/akt on abrogation of cytokine-dependency induced by oncogenic raf  Journal Articles
• The Role of Dietary Fat throughout the Prostate Cancer Trajectory  Journal Articles
• The antiapoptotic effect of guanosine is mediated by the activation of the PI 3‐kinase/AKT/PKB pathway in cultured rat astrocytes  Journal Articles
• Uncoupling of Pro- and Anti-Inflammatory Properties of Staphylococcus aureus  Journal Articles
• α-Mannosidase 2C1 attenuates PTEN function in prostate cancer cells  Journal Articles