Journal article
Epigenetic mechanisms of melatonin action in human SH-SY5Y neuroblastoma cells
Abstract
We have shown that melatonin induces histone hyperacetylation in vitro and in vivo. To clarify the mechanisms involved, we have now investigated its effects on histone acetylation and signaling pathways in human SH-SY5Y neuroblastoma cells, which express melatonin MT1 receptors. Melatonin caused significant concentration-dependent increases in both histone H3 and H4 acetylation. Blockade of melatonin receptors with luzindole abolished the …
Authors
Pan Y; Niles LP
Journal
Molecular and Cellular Endocrinology, Vol. 402, , pp. 57–63
Publisher
Elsevier
Publication Date
February 2015
DOI
10.1016/j.mce.2015.01.003
ISSN
0303-7207
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AcetylationCell Line, TumorChromatin Assembly and DisassemblyEpigenesis, GeneticGene Expression Regulation, NeoplasticHistonesHumansMelatoninNeuroblastomaProtein Processing, Post-TranslationalProto-Oncogene Proteins c-aktReceptor, Melatonin, MT1Signal TransductionTryptaminesp300-CBP Transcription Factors