Journal article
Parathyroid hormone-related protein induces fibronectin upregulation in rat mesangial cells through reactive oxygen species/Src/EGFR signaling
Abstract
Parathyroid hormone-related protein (PTHrP) is known to be up-regulated in both glomeruli and tubules in patients with diabetic kidney disease (DKD), but its role remains unclear. Previous studies show that PTHrP-induced hypertrophic response in mesangial cells (MCs) and epithelial-mesenchymal transition (EMT) in tubuloepithelial cells can be mediated by TGF-β1. In the present study, although long-term PHTrP (1-34) treatment increased the mRNA …
Authors
Chen H-M; Dai J-J; Zhu R; Peng F-F; Wu S-Z; Yu H; Krepinsky JC; Zhang B-F
Journal
Bioscience Reports, Vol. 39, No. 4,
Publisher
Portland Press
Publication Date
April 30, 2019
DOI
10.1042/bsr20182293
ISSN
0144-8463
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AnimalsDiabetic NephropathiesEpithelial-Mesenchymal TransitionErbB ReceptorsFibronectinsHumansKidney GlomerulusKidney TubulesMAP Kinase Signaling SystemMesangial CellsParathyroid Hormone-Related ProteinPhosphorylationProto-Oncogene Proteins c-aktRatsReactive Oxygen SpeciesTransforming Growth Factor beta1src-Family Kinases